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Protein Page:
MKK7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MKK7 a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, STE; Kinase, protein; EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: MAP kinase kinase activity; protein C-terminus binding; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; JUN kinase kinase activity; protein kinase binding; protein phosphatase binding; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; apoptosis; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; activation of JNK activity; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of neuron apoptosis; toll-like receptor signaling pathway; response to stress; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  O14733 (UniProtKB)
Alt. Names/Synonyms: c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; JNKK2; MAP kinase kinase 7; MAP2K7; MAPK/ERK kinase 7; MAPKK 7; MAPKK7; MEK 7; MEK7; mitogen-activated protein kinase kinase 7; MKK7; MP2K7; PRKMK7
Gene Symbols: MAP2K7
Molecular weight: 47,485 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Parkinson's Disease  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MKK7

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S271‑p, T275‑p
enzymatic activity, induced: S271‑p, T275‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K9 AASSLEQKLSRLEAK
0 1 S35-p IDLNLDIsPQRPRPT
0 1 S61-p RSPSSESsPQHPtPP
0 4 T66-p ESsPQHPtPPARPRH
0 1 S79-p RHMLGLPsTLFtPRs
0 15 T83-p GLPsTLFtPRsMEsI
0 1 S86-p sTLFtPRsMEsIEID
0 1 S89-p FtPRsMEsIEIDQkL
0 1 K95-ub EsIEIDQkLQEIMKQ
0 1 T142-p WKMRFRKtGHVIAVK
0 1 K245-ub GVIHRDVkPSNILLD
2 0 S271-p ISGRLVDsKAKtRsA
2 1 T275-p LVDsKAKtRsAGCAA
0 1 S277-p DsKAKtRsAGCAAYM
0 1 K326 QFPYKNCKTDFEVLT
0 1 K373-ub RKRPKYNkLLEHsFI
0 1 S378-p YNkLLEHsFIKRYET
0 1 S403-p DVMAKTEsPRtsGVL
0 1 T406-p AKTEsPRtsGVLsQP
0 1 S407-p KTEsPRtsGVLsQPH
0 1 S411-p PRtsGVLsQPHLPFF
0 1 - gap
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
  mouse

 
K9-ub AASSLEQkLSRLEAK
S35 IDLNLDISPQRPRPI
S77-p RSPSSESsPQHPtPP
T82-p ESsPQHPtPPTRPRH
S95 RHMLGLPSTLFTPRS
T99 GLPSTLFTPRSMESI
S102 STLFTPRSMESIEID
S105 FTPRSMESIEIDQKL
K111 ESIEIDQKLQEIMKQ
T158 WKMRFRKTGHIIAVK
K261 GVIHRDVKPSNILLD
S287-p ISGRLVDsKAKtRSA
T291-p LVDsKAKtRSAGCAA
S293 DsKAKtRSAGCAAYM
K342-ub QFPYKNCkTDFEVLT
K389 RKRPKYNKLLEHSFI
S394 YNKLLEHSFIKHYEI
S419 DVMAKTESPRTSGVL
T422 AKTESPRTSGVLSQH
S423 KTESPRTSGVLSQHH
S427 PRTSGVLSQHHLPFF
S464-p RCRGRVPsPRRATGG
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
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