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MKK7 (human)

Overview MKK7 a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: Protein kinase, STE; EC 2.7.12.2; Protein kinase, dual-specificity; Kinase, protein; STE group; STE7 family Cellular Component: cytoplasm; nucleus; cytosol Molecular Function: protein C-terminus binding; MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; JUN kinase kinase activity; protein kinase binding; protein phosphatase binding; ATP binding Biological Process: apoptosis; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; Toll signaling pathway; activation of JNK activity; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of neuron apoptosis; toll-like receptor signaling pathway; JNK cascade; response to stress; innate immune response; toll-like receptor 4 signaling pathway Reference #:  O14733 (UniProtKB) Alt. Names/Synonyms: c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; JNKK2; MAP kinase kinase 7; MAP2K7; MAPK/ERK kinase 7; MAPKK 7; MAPKK7; MEK 7; MEK7; mitogen-activated protein kinase kinase 7; MKK7; MP2K7; PRKMK7 Gene Symbols: MAP2K7 Molecular weight: 47,485 Da Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Jak/Stat/IL-6 Signaling  |  Parkinson's Disease  |  Regulation of Actin Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MKK7 2DYL - A=101-405 (human)

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	Sites Implicated In
transcription, altered: S271‑p, T275‑p enzymatic activity, induced: S271‑p, T275‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K9	AASSLEQKLSRLEAK
0	1		S35-p	IDLNLDIsPQRPRPT
0	1		T66-p	ESSPQHPtPPARPRH
0	14		T83-p	GLPSTLFtPRsMEsI
0	1		S86-p	STLFtPRsMEsIEID
0	1		S89-p	FtPRsMEsIEIDQkL
0	1		K95-u	EsIEIDQkLQEIMKQ
0	1		T142-p	WKMRFRKtGHVIAVK
0	1		K245-u	GVIHRDVkPSNILLD
2	0		S271-p	ISGRLVDsKAKtRsA
2	1		T275-p	LVDsKAKtRsAGCAA
0	1		S277-p	DsKAKtRsAGCAAYM
0	1		K326	QFPYKNCKTDFEVLT
0	1		K373-u	RKRPKYNkLLEHsFI
0	1		S378-p	YNkLLEHsFIKRYET
0	1		-	gap

	mouse
K9-u	AASSLEQkLSRLEAK
S35	IDLNLDISPQRPRPI
T82-p	ESSPQHPtPPTRPRH
T99	GLPSTLFTPRSMESI
S102	STLFTPRSMESIEID
S105	FTPRSMESIEIDQKL
K111	ESIEIDQKLQEIMKQ
T158	WKMRFRKTGHIIAVK
K261	GVIHRDVKPSNILLD
S287-p	ISGRLVDsKAKtRSA
T291-p	LVDsKAKtRSAGCAA
S293	DsKAKtRSAGCAAYM
K342-u	QFPYKNCkTDFEVLT
K389	RKRPKYNKLLEHSFI
S394	YNKLLEHSFIKHYEI
S464-p	RCRGRVPsPRRATGG

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