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Protein Page:
MMP2 (human)

Overview
MMP2 Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Interacts (via the C-terminal hemopexin-like domains- containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B. Aspirin appears to inhibit expression. Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. Inhibited by histatin-3 1/24 (histatin-5). Belongs to the peptidase M10A family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Apoptosis; Cell development/differentiation; Motility/polarity/chemotaxis; EC 3.4.24.24; Secreted; Protease
Cellular Component: extracellular space; proteinaceous extracellular matrix; sarcomere; mitochondrion; plasma membrane; extracellular region; nucleus
Molecular Function: protein binding; zinc ion binding; serine-type endopeptidase activity; metalloendopeptidase activity
Biological Process: collagen catabolic process; extracellular matrix disassembly; intramembranous ossification; extracellular matrix organization and biogenesis; cellular protein metabolic process; response to hypoxia; angiogenesis; proteolysis; blood vessel maturation; embryo implantation
Reference #:  P08253 (UniProtKB)
Alt. Names/Synonyms: 72 kDa gelatinase; 72 kDa type IV collagenase; CLG4; CLG4A; collagenase type IV-A; Gelatinase A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Matrix metalloproteinase-2; matrix metalloproteinase-II; MMP-2; MMP-II; MMP2; MONA; neutrophil gelatinase; PEX; TBE-1
Gene Symbols: MMP2
Molecular weight: 73,882 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MMP2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T11-p LMARGALtGPLRALC
1 0 S160-p DVTPLRFsRIHDGEA
0 1 S246-p FNGKEYNsCTDtGRS
1 0 T250-p EYNsCTDtGRSDGFL
0 1 T261-p DGFLWCStTYNFEKD
0 1 Y360-p FTFLGNKyEsCtsAG
0 1 S362-p FLGNKyEsCtsAGRs
0 2 T364-p GNKyEsCtsAGRsDG
1 1 S365-p NKyEsCtsAGRsDGK
0 1 S369-p sCtsAGRsDGKMWCA
1 0 T377-p DGKMWCAttANYDDD
1 0 T378-p GKMWCAttANYDDDR
  mouse

 
A11 RVAWGALAGPLRVLC
S160 DVTPLRFSRIHDGEA
S246 FNGREYSSCTDTGRS
T250 EYSSCTDTGRSDGFL
T261 DGFLWCSTTYNFEKD
Y360 FTFLGNKYESCTSAG
S362 FLGNKYESCTSAGRN
T364 GNKYESCTSAGRNDG
S365 NKYESCTSAGRNDGK
N369 SCTSAGRNDGKVWCA
T377 DGKVWCATTTNYDDD
T378 GKVWCATTTNYDDDR
  rat

 
V11 RLVWGVLVGPLRVLC
S160 DVTPLRFSRIHDGEA
S246 FNGREYSSCTDTGRS
T250 EYSSCTDTGRSDGFL
T261 DGFLWCSTTYNFEKD
Y360 FTFLGNKYESCTSAG
S362 FLGNKYESCTSAGRN
T364 GNKYESCTSAGRNDG
S365 NKYESCTSAGRNDGK
N369 SCTSAGRNDGKVWCA
T377 DGKVWCATTTNYDDD
T378 GKVWCATTTNYDDDR
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