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Protein Page:
IGBP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IGBP1 Associated to surface IgM-receptor; may be involved in signal transduction. May be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases. Associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6. Interacts with MID1 and MID2. Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas. Belongs to the IGBP1/TAP42 family. Note: This description may include information from UniProtKB.
Protein type: Phosphatase, regulatory subunit; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq13.1-q13.3
Cellular Component: cytoplasm; cytosol; microtubule
Molecular Function: mitogen-activated protein kinase kinase binding; protein binding; protein complex binding; protein domain specific binding; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity
Biological Process: B cell activation; negative regulation of caspase activity; negative regulation of protein amino acid dephosphorylation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dephosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of protein phosphatase type 2A activity; signal transduction
Disease: Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma, And Micrognathia
Reference #:  P78318 (UniProtKB)
Alt. Names/Synonyms: ALPHA-4; B cell signal transduction molecule alpha 4; B-cell signal transduction molecule alpha 4; bA351K23.1 (immunoglobulin binding protein 1 (CD79A) ); CD79a-binding protein 1; IBP1; IGBP1; immunoglobulin (CD79A) binding protein 1; immunoglobulin binding protein 1; Immunoglobulin-binding protein 1; Protein alpha-4; protein phosphatase 2A, regulatory subunit alpha-4; Renal carcinoma antigen NY-REN-16
Gene Symbols: IGBP1
Molecular weight: 39,222 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IGBP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 A3 _____MAAEDELQLP
0 1 T18 RLPELFETGRQLLDE
0 1 T30 LDEVEVATEPAGSRI
0 1 S35 VATEPAGSRIVQEKV
0 3 K44‑ub IVQEKVFkGLDLLEK
0 1 K91‑ub FQGALTMkQVNPsKR
0 1 S96‑p TMkQVNPsKRLDHLQ
0 21 Y145‑p TANSSMAyPSLVAMA
0 2 S173‑p KELEHRLsAMkSAVE
0 1 K176‑ub EHRLsAMkSAVEsGQ
0 1 S181‑p AMkSAVEsGQADDER
0 1 R225‑m2 LRERDSSrEASTSNS
0 3 K241‑ac RQERPPVkPFILTRN
0 1 K241‑ub RQERPPVkPFILTRN
0 1 K253‑ub TRNMAQAkVFGAGyP
0 1 Y259‑p AkVFGAGyPsLPtMt
0 5 S261‑p VFGAGyPsLPtMtVs
0 3 T264‑p AGyPsLPtMtVsDWy
0 3 T266‑p yPsLPtMtVsDWyEQ
0 8 S268‑p sLPtMtVsDWyEQHR
0 38 Y271‑p tMtVsDWyEQHRKyG
0 14 Y277‑p WyEQHRKyGALPDQG
1 1 K287‑ub LPDQGIAkAAPEEFR
0 1 P290 QGIAkAAPEEFRkAA
0 2 K295‑ub AAPEEFRkAAQQQEE
  mouse

 
S4‑p ____MAAsEDELLLP
T19‑p RLPELFEtSKKLLED
T31‑p LEDVEVAtEPTGsRT
S36‑p VAtEPTGsRTIQDKV
K45‑ub TIQDKVSkGLELLEK
K92 LQGALTMKQVNPsKR
S97‑p TMKQVNPsKRLDHLQ
Y146 TASSSMAYPNLVAMA
S174 KEVEHRLSALKSAVE
K177 EHRLSALKSAVESGQ
S182 ALKSAVESGQADDER
R226 LKEKDSPREETACHS
K242 LPEKPPMKPFILTRN
K242 LPEKPPMKPFILTRN
K254 TRNKAQAKVFGTGYP
Y260 AKVFGTGYPSLATMT
S262 VFGTGYPSLATMTVS
T265 TGYPSLATMTVSDWY
T267 YPSLATMTVSDWYEQ
S269 SLATMTVSDWYEQHQ
Y272 TMTVSDWYEQHQKYG
Y278 WYEQHQKYGVLPDRG
K288 LPDRGIAKPAsADFQ
S291‑p RGIAKPAsADFQRAA
R296 PAsADFQRAAQQQED
  rat

 
S4 ____MAASEEELLLP
T19 RLPELFETSKKLLEE
T31 LEELEVATEPTGSRT
S36 VATEPTGSRTIQDKV
K45 TIQDKVSKGLELLEK
K92 LQGALTMKQVNPSKR
S97 TMKQVNPSKRLDHLQ
Y146 TARSSMAYPNLVAMA
S174 KEVEHRLSALKSAVE
K177 EHRLSALKSAVESGQ
S182 ALKSAVESGQADDER
R226 LKDKDSPREESACQS
K242 LPEKPPMKPFILTRN
K242 LPEKPPMKPFILTRN
K254 TRNKAQAKVFGTGYP
Y260 AKVFGTGYPSLATMT
S262 VFGTGYPSLATMTVS
T265 TGYPSLATMTVSDWY
T267 YPSLATMTVSDWYEQ
S269 SLATMTVSDWYEQHQ
Y272 TMTVSDWYEQHQKYG
Y278 WYEQHQKYGALPDRG
K288 LPDRGIAKPPSADFQ
S291 RGIAKPPSADFQRAA
R296 PPSADFQRAAQQQED
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