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Protein Page:
MALT1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MALT1 Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Belongs to the peptidase C14B family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.-; Adaptor/scaffold; Protease; Apoptosis; Ligase; Nuclear export; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 18q21
Cellular Component: CBM complex; cytoplasm; cytosol; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex
Molecular Function: cysteine-type endopeptidase activity; kinase activator activity; peptidase activity; protease binding; protein binding; protein self-association; signal transducer activity; ubiquitin-protein ligase activity
Biological Process: activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; B-1 B cell differentiation; defense response; innate immune response; negative regulation of apoptosis; nuclear export; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 production; positive regulation of protein ubiquitination; positive regulation of T cell activation; positive regulation of T cell cytokine production; protein oligomerization; protein ubiquitination; proteolysis; regulation of apoptosis; regulation of T cell receptor signaling pathway; response to fungus; response to molecule of bacterial origin; stimulatory C-type lectin receptor signaling pathway; T cell proliferation; T cell receptor signaling pathway
Disease: Immunodeficiency 12
Reference #:  Q9UDY8 (UniProtKB)
Alt. Names/Synonyms: caspase-like protein; DKFZp434L132; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation; MALT1; MLT; MLT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Paracaspase
Gene Symbols: MALT1
Molecular weight: 92,272 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MALT1

Protein Structure Not Found.


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Modification Sites and Domains  
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Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2‑p ______MsLLGDPLQ
0 2 L11 LGDPLQALPPSAAPt
0 1 T18‑p LPPSAAPtGPLLAPP
0 3 T29‑p LAPPAGAtLNRLREP
0 1 S42‑p EPLLRRLsELLDQAP
0 2 S70‑p SRGRLRLsCLDLEQC
0 1 S87‑p KVLEPEGsPSLCLLK
0 1 S123‑p TEVLQLLsPPGIKIT
0 6 S135‑p KITVNPEsKAVLAGQ
0 1 S253‑p LQCVAVGsPIPHYQW
0 1 T387‑p VVSLLDLtEYEMRNA
2 0 K644‑ub LDLDIDPkDANkGTP
1 1 K648‑ub IDPkDANkGTPEETG
1 0 K661‑ub TGSYLVSkDLPkHCL
1 0 K665‑ub LVSkDLPkHCLYTRL
0 1 S674‑p CLYTRLSsLQkLkEH
1 0 K677‑ub TRLSsLQkLkEHLVF
1 0 K679‑ub LSsLQkLkEHLVFTV
1 0 K702‑ub LEDTVEDkQEVNVGk
1 0 K709‑ub kQEVNVGkPLIAkLD
1 0 K714‑ub VGkPLIAkLDMHRGL
1 0 K724‑ub MHRGLGRkTCFQTCL
0 1 S795‑p SSFAHHAsCHFSRSN
1 0 K824‑ub DRLRISEk_______
  mouse

 
S2 ______MSLWGQPLQ
S11‑p WGQPLQAsPPLAVRQ
S24 RQPPTASSGPSTSPP
T35 TSPPAGATLNRLPEP
S48 EPLLRRLSESLDRAP
S76 SRGRLRLSGLDLEQC
S93 KVLEPEGSPSLCLLK
N129 TEVLPLLNPPGLKIT
S141‑p KITVNPEsKAVLAGQ
S262 LQCVAIGSPMPHYQW
T395 VVSLLDLTEYEMCNA
K652 LDLDIDPKHANKGTP
K656 IDPKHANKGTPEETG
K669 TGSYLVSKDLPKHCL
K673 LVSKDLPKHCLYTRL
S682 CLYTRLSSLQKLKEH
K685 TRLSSLQKLKEHLIF
K687 LSSLQKLKEHLIFTV
K710 LEDTVEEKQEVNVGK
K717 KQEVNVGKPLIAKLD
K722 VGKPLIAKLDMHRGL
K732 MHRGLGRKTCFQACR
Y803 SNYPPHHYCQFGRSN
N832 DRLMISEN_______
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