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Protein Page:
LAT (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LAT an adaptor protein involved in T-cell antigen receptor (TCR) signal transduction pathway. Plays an important role downstream of protein tyrosine kinases. Essential for TCR-mediated Ras-Erk activation and calcium flux. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: immunological synapse; integral to membrane; lipid raft; plasma membrane; signalosome
Molecular Function: protein binding; protein kinase binding; Ras guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity
Biological Process: calcium-mediated signaling; immune response; integrin-mediated signaling pathway; MAPKKK cascade; platelet activation; positive regulation of protein kinase activity; Ras protein signal transduction; regulation of T cell activation; T cell activation; T cell receptor signaling pathway
Reference #:  O43561 (UniProtKB)
Alt. Names/Synonyms: 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; LAT; LAT1; linker for activation of T cells; Linker for activation of T-cells family member 1; p36-38; pp36
Gene Symbols: LAT
Molecular weight: 27,930 Da
Basal Isoelectric point: 4.27  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LAT

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: Y200‑p, Y220‑p
transcription, altered: Y200‑p, Y220‑p, Y255‑p
transcription, induced: Y200‑p, Y220‑p
activity, induced: Y200‑p, Y220‑p, Y255‑p
molecular association, regulation: Y161‑p, Y200‑p, Y220‑p, Y255‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S35‑p HCHRLPGsyDstssD
0 2 Y36‑p CHRLPGsyDstssDs
0 1 S38‑p RLPGsyDstssDsLy
0 4 T39‑p LPGsyDstssDsLyP
0 7 S40‑p PGsyDstssDsLyPR
0 6 S41‑p GsyDstssDsLyPRG
0 16 S43‑p yDstssDsLyPRGIQ
0 69 Y45‑p stssDsLyPRGIQFk
0 1 K52 yPRGIQFKRPHTVAP
2 0 K52‑ub yPRGIQFkRPHTVAP
0 2 T68‑p PPAYPPVtSyPPLsQ
0 3 Y70‑p AYPPVtSyPPLsQPD
0 7 S74‑p VtSyPPLsQPDLLPI
0 23 S84‑p DLLPIPRsPQPLGGs
0 12 S91‑p sPQPLGGsHRtPssR
0 1 T94‑p PLGGsHRtPssRRDs
0 2 S96‑p GGsHRtPssRRDsDG
0 4 S97‑p GsHRtPssRRDsDGA
0 10 S101‑p tPssRRDsDGANsVA
0 7 S106‑p RDsDGANsVAsyENE
0 7 S109‑p DGANsVAsyENEGAS
1 2 Y110‑p GANsVAsyENEGASG
0 1 S131‑p GWGVWGPsWTRLTPV
3 1 Y156‑p ADEDEDDyHNPGyLV
18 1 Y161‑p DDyHNPGyLVVLPDS
0 1 S183‑p APSAPALstPGIRDS
1 11 T184‑p PSAPALstPGIRDSA
15 17 Y200‑p SMESIDDyVNVPEsG
0 4 S206‑p DyVNVPEsGESAEAs
0 5 S213‑p sGESAEAsLDGsREy
0 2 S217‑p AEAsLDGsREyVNVs
28 46 Y220‑p sLDGsREyVNVsQEL
0 29 S224‑p sREyVNVsQELHPGA
1 0 K233 ELHPGAAKTEPAALs
0 2 A238 AAKTEPAALssQEAE
0 1 S240‑p KTEPAALssQEAEEV
0 2 S241‑p TEPAALssQEAEEVE
12 74 Y255‑p EEEGAPDyENLQELN
3581 : Phospho-LAT (Tyr171) Antibody
3584 : Phospho-LAT (Tyr191) Antibody
  LAT iso2  
S35 HCHRLPGSYDSTSSD
Y36 CHRLPGSYDSTSSDS
S38 RLPGSYDSTSSDSLY
T39 LPGSYDSTSSDSLYP
S40 PGSYDSTSSDSLYPR
S41 GSYDSTSSDSLYPRG
S43 YDSTSSDSLYPRGIQ
Y45 STSSDSLYPRGIQFk
K52 YPRGIQFKRPHTVAP
K52‑ub YPRGIQFkRPHTVAP
T68 PPAYPPVTSYPPLSQ
Y70 AYPPVTSYPPLSQPD
S74 VTSYPPLSQPDLLPI
S84 DLLPIPRSPQPLGGS
S91 SPQPLGGSHRTPSSR
T94 PLGGSHRTPSSRRDS
S96 GGSHRTPSSRRDSDG
S97 GSHRTPSSRRDSDGA
S101 TPSSRRDSDGANSVA
S106 RDSDGANSVASyENE
S109 DGANSVASyENEEPA
Y110‑p GANSVASyENEEPAC
- gap
Y127‑p ADEDEDDyHNPGyLV
Y132‑p DDyHNPGyLVVLPDS
S154 APSAPALStPGIRDS
T155‑p PSAPALStPGIRDSA
Y171‑p SMESIDDyVNVPESG
S177 DyVNVPESGESAEAS
S184 SGESAEASLDGSREy
S188 AEASLDGSREyVNVS
Y191‑p SLDGSREyVNVSQEL
S195 SREyVNVSQELHPGA
K204‑ub ELHPGAAkTEPAALS
A209 AAkTEPAALSSQEAE
S211 kTEPAALSSQEAEEV
S212 TEPAALSSQEAEEVE
Y226‑p EEEGAPDyENLQELN
  LAT iso3  
S71 HCHRLPGSYDSTSSD
Y72 CHRLPGSYDSTSSDS
S74 RLPGSYDSTSSDSLY
T75 LPGSYDSTSSDSLYP
S76 PGSYDSTSSDSLYPR
S77 GSYDSTSSDSLYPRG
S79 YDSTSSDSLYPRGIQ
Y81 STSSDSLYPRGIQFK
K88 YPRGIQFKRPHTVAP
K88 YPRGIQFKRPHTVAP
T104 PPAYPPVTSYPPLSQ
Y106 AYPPVTSYPPLSQPD
S110 VTSYPPLSQPDLLPI
S120 DLLPIPRSPQPLGGS
S127 SPQPLGGSHRTPSSR
T130 PLGGSHRTPSSRRDS
S132 GGSHRTPSSRRDSDG
S133 GSHRTPSSRRDSDGA
S137 TPSSRRDSDGANSVA
S142 RDSDGANSVASYENE
S145 DGANSVASYENEEPA
Y146 GANSVASYENEEPAC
- gap
Y163 ADEDEDDYHNPGYLV
Y168 DDYHNPGYLVVLPDS
S190 APSAPALSTPGIRDS
T191 PSAPALSTPGIRDSA
Y207 SMESIDDYVNVPESG
S213 DYVNVPESGESAEAS
S220 SGESAEASLDGSREY
S224 AEASLDGSREYVNVS
Y227 SLDGSREYVNVSQEL
S231 SREYVNVSQELHPGA
K240 ELHPGAAKTEPAALS
A245 AAKTEPAALSSQEAE
S247 KTEPAALSSQEAEEV
S248 TEPAALSSQEAEEVE
Y262 EEEGAPDYENLQELN
  LAT iso4  
S35 HCHRLPGSYDSTSSD
Y36 CHRLPGSYDSTSSDS
S38 RLPGSYDSTSSDSLY
T39 LPGSYDSTSSDSLYP
S40 PGSYDSTSSDSLYPR
S41 GSYDSTSSDSLYPRG
S43 YDSTSSDSLYPRGIQ
Y45 STSSDSLYPRGIQFK
K52 YPRGIQFKRPHTVAP
K52 YPRGIQFKRPHTVAP
T68 PPAYPPVTSYPPLSQ
Y70 AYPPVTSYPPLSQPD
S74 VTSYPPLSQPDLLPI
S83‑p PDLLPIPsPQPLGGS
S90 sPQPLGGSHRTPSSR
T93 PLGGSHRTPSSRRDS
S95 GGSHRTPSSRRDSDG
S96 GSHRTPSSRRDSDGA
S100 TPSSRRDSDGANSVA
S105 RDSDGANSVASYENE
S108 DGANSVASYENEEPA
Y109 GANSVASYENEEPAC
- gap
Y126 ADEDEDDYHNPGYLV
Y131 DDYHNPGYLVVLPDS
S153 APSAPALSTPGIRDS
T154 PSAPALSTPGIRDSA
Y170 SMESIDDYVNVPESG
S176 DYVNVPESGESAEAS
S183 SGESAEASLDGSREY
S187 AEASLDGSREYVNVS
Y190 SLDGSREYVNVSQEL
S194 SREYVNVSQELHPGA
K203 ELHPGAAKTEPAALS
A208 AAKTEPAALSSQEAE
S210 KTEPAALSSQEAEEV
S211 TEPAALSSQEAEEVE
Y225 EEEGAPDYENLQELN
  mouse

 
S36 RCRELPVSYDStstE
Y37 CRELPVSYDStstEs
S39 ELPVSYDStstEsLY
T40‑p LPVSYDStstEsLYP
S41‑p PVSYDStstEsLYPR
T42‑p VSYDStstEsLYPRS
S44‑p YDStstEsLYPRSIL
Y46 StstEsLYPRSILIK
K53 YPRSILIKPPQITVP
K53 YPRSILIKPPQITVP
T71 AVSYPLVTSFPPLRQ
F73 SYPLVTSFPPLRQPD
R77 VTSFPPLRQPDLLPI
S87‑p DLLPIPRsPQPLGGs
S94‑p sPQPLGGsHRMPSSQ
M97 PLGGsHRMPSSQQNS
S99 GGsHRMPSSQQNSDD
S100 GsHRMPSSQQNSDDA
S104 MPSSQQNSDDANsVA
S109‑p QNSDDANsVAsyENQ
S112‑p DDANsVAsyENQEPA
Y113‑p DANsVAsyENQEPAC
- gap
Y132 ADEDEDDYPNGyLVV
Y136‑p EDDYPNGyLVVLPDS
S158 VSSAPVPSNPDLGDS
N159 SSAPVPSNPDLGDSA
Y175‑p SVESCEDyVNVPESE
S181 DyVNVPESEESAEAS
S188 SEESAEASLDGSREy
S192 AEASLDGSREyVNVs
Y195‑p SLDGSREyVNVsPEQ
S199‑p SREyVNVsPEQQPVT
- gap
S212‑p VTRAELAsVNsQEVE
N214 RAELAsVNsQEVEDE
S215‑p AELAsVNsQEVEDEG
Y235‑p DGEEAPDyENLQELN
3581 : Phospho-LAT (Tyr171) Antibody
3584 : Phospho-LAT (Tyr191) Antibody
  rat

 
S36 RCRELPASYDSAsTE
Y37 CRELPASYDSAsTES
S39 ELPASYDSAsTESLY
A40 LPASYDSAsTESLYP
S41‑p PASYDSAsTESLYPR
T42 ASYDSAsTESLYPRS
S44 YDSAsTESLYPRSIL
Y46 SAsTESLYPRSILIk
K53‑ac YPRSILIkPPQITVP
K53 YPRSILIKPPQITVP
T71 ATSYPLVTSFPPLRQ
F73 SYPLVTSFPPLRQPD
R77 VTSFPPLRQPDLLPI
S87‑p DLLPIPRsPQPLGGS
S94 sPQPLGGSHRMPSSR
M97 PLGGSHRMPSSRQNs
S99 GGSHRMPSSRQNsDD
S100 GSHRMPSSRQNsDDA
S104‑p MPSSRQNsDDANsVA
S109‑p QNsDDANsVAsYENQ
S112‑p DDANsVAsYENQEPA
Y113 DANsVAsYENQEPAR
- gap
Y132 EDEDEDDYPEGYLVV
Y136 EDDYPEGYLVVLPDS
S158 VSSAPVPSNPDLGDS
N159 SSAPVPSNPDLGDSA
Y175 SMESCEDYVNVPESE
S181 DYVNVPESEESAEAS
S188 SEESAEASLDGSREY
S192 AEASLDGSREYVNVs
Y195 SLDGSREYVNVsQDA
S199‑p SREYVNVsQDAQPVI
- gap
S212‑p VIRAELAsVTSQEVE
T214 RAELAsVTSQEVEDE
S215 AELAsVTSQEVEDEE
Y234‑p DGEEAPDyENLQELN
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