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Protein Page:
ITGB3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITGB3 integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: cell surface; filopodium membrane; focal adhesion; integral to plasma membrane; integrin complex; melanosome; microvillus membrane; nucleus; plasma membrane; platelet alpha granule membrane; receptor complex
Molecular Function: C-X3-C chemokine binding; cell adhesion molecule binding; coreceptor activity; enzyme binding; extracellular matrix binding; fibronectin binding; identical protein binding; platelet-derived growth factor receptor binding; protease binding; protein binding; protein disulfide isomerase activity; vascular endothelial growth factor receptor 2 binding; viral receptor activity
Biological Process: activation of protein kinase activity; angiogenesis involved in wound healing; blood coagulation; cell adhesion; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; entry of virus into host cell; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte migration; mesodermal cell differentiation; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; platelet activation; platelet degranulation; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein folding; regulation of bone resorption; smooth muscle cell migration; tube development; vascular endothelial growth factor receptor signaling pathway; wound healing
Disease: Bleeding Disorder, Platelet-type, 16; Glanzmann Thrombasthenia; Myocardial Infarction, Susceptibility To
Reference #:  P05106 (UniProtKB)
Alt. Names/Synonyms: CD61; GP3A; GPIIIa; Integrin beta-3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITB3; ITGB3; platelet glycoprotein IIIa; Platelet membrane glycoprotein IIIa
Gene Symbols: ITGB3
Molecular weight: 87,058 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ITGB3

Protein Structure Not Found.
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Sites Implicated In
cell adhesion, altered: Y773‑p, S778‑p, Y785‑p
cell motility, altered: Y773‑p, S778‑p
cytoskeletal reorganization: Y773‑p, Y785‑p
activity, induced: Y773‑p
activity, inhibited: Y773‑p, S778‑p, Y785‑p
molecular association, regulation: Y773‑p, S778‑p, Y785‑p
protein conformation: S778‑p
protein processing: Y773‑p, Y785‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T208‑p NPCYDMKtTCLPMFG
0 1 T227‑p LTLTDQVtRFNEEVK
0 1 S439‑p CPQEKEKsFtIKPVG
0 1 T441‑p QEKEKsFtIKPVGFK
0 1 Y660‑p DENTCNRyCRDEIES
0 3 T767‑p RARAKWDtANNPLyK
20 104 Y773‑p DtANNPLyKEAtstF
0 1 K774 tANNPLyKEAtstFT
1 1 T777‑p NPLyKEAtstFTNIt
1 0 S778‑gl PLyKEAtstFTNIty
3 0 S778‑p PLyKEAtstFTNIty
2 3 T779‑p LyKEAtstFTNItyR
1 0 T784‑gl tstFTNItyRGT___
1 1 T784‑p tstFTNItyRGT___
18 8 Y785‑p stFTNItyRGT____
  mouse

 
N207 NPCYNMKNACLPMFG
S226 LTLTDQVSRFNEEVK
S438 CPQEKEQSFTIKPVG
T440 QEKEQSFTIKPVGFK
Y659 EENTCSRYCRDDIEQ
T766‑p RARAKWDtANNPLyk
Y772‑p DtANNPLykEATStF
K773‑ub tANNPLykEATStFT
T776 NPLykEATStFTNIT
S777 PLykEATStFTNITy
S777 PLykEATStFTNITy
T778‑p LykEATStFTNITyR
T783 TStFTNITyRGT___
T783 TStFTNITyRGT___
Y784‑p StFTNITyRGT____
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