a regulatory protein that inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Note: This description may include information from UniProtKB.
Molecular Function: enzyme binding; identical protein binding; NF-kappaB binding; nuclear localization sequence binding; protein binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process: activation of NF-kappaB transcription factor; apoptosis; cytoplasmic sequestering of NF-kappaB; cytoplasmic sequestering of transcription factor; inhibition of NF-kappaB transcription factor; negative regulation of apoptosis; positive regulation of cellular protein metabolic process; positive regulation of transcription from RNA polymerase II promoter; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.