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Protein Page:
HDAC5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HDAC5 a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Coimmunoprecipitates only with HDAC3 family members. Interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; EC 3.5.1.98
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytoplasm; Golgi apparatus; histone deacetylase complex; nucleoplasm; nucleus
Molecular Function: histone deacetylase activity; histone deacetylase binding; protein binding; protein deacetylase activity; protein kinase C binding; transcription factor binding
Biological Process: B cell activation; B cell differentiation; chromatin modification; chromatin remodeling; chromatin silencing; establishment and/or maintenance of chromatin architecture; histone deacetylation; inflammatory response; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein amino acid deacetylation; regulation of gene expression, epigenetic; regulation of protein binding
Reference #:  Q9UQL6 (UniProtKB)
Alt. Names/Synonyms: Antigen NY-CO-9; FLJ90614; HD5; HDAC5; Histone deacetylase 5; KIAA0600; NY-CO-9
Gene Symbols: HDAC5
Molecular weight: 121,978 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HDAC5

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S259‑p, S498‑p
cell cycle regulation: S259‑p, S498‑p
cell differentiation, altered: S259‑p, S498‑p
cell motility, altered: S259‑p, S498‑p
chromatin organization, altered: S259‑p, S498‑p
neural plasticity: S279‑p
transcription, altered: S259‑p, S498‑p
transcription, induced: S259‑p, S498‑p
transcription, inhibited: S279‑p
enzymatic activity, induced: S278‑p, S279‑p
enzymatic activity, inhibited: S259‑p, S498‑p
intracellular localization: S259‑p, S279‑p, S498‑p, S661‑p
molecular association, regulation: S259‑p, S278‑p, S279‑p, S498‑p
protein conformation: S279‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S3‑p _____MNsPNEsDGM
0 1 S7‑p _MNsPNEsDGMSGRE
0 1 K35‑sm IPVTVEVkPVLPRAM
0 4 S53‑p MGGGGGGsPsPVELR
0 1 S55‑p GGGGGsPsPVELRGA
0 1 S66‑p LRGALVGsVDPtLRE
0 1 T70‑p LVGsVDPtLREQQLQ
0 1 S180‑p SKESAIAstEVKLRL
0 1 T181‑p KESAIAstEVKLRLQ
0 1 S206‑p TPGGLNHsLPQHPKC
0 1 T234‑p PQSGPPGtPPSYKLP
21 35 S259‑p FPLRKTAsEPNLKVR
2 11 S278‑p QKVAERRssPLLRRK
5 15 S279‑p KVAERRssPLLRRKD
0 1 T288‑p LLRRKDGtVIstFKK
0 1 S291‑p RKDGtVIstFKKRAV
1 1 T292‑p KDGtVIstFKKRAVE
0 1 S368‑p FSLYTSPsLPNISLG
0 1 S469‑p AVPLHGQsPLVTGER
0 2 T496‑p RHRPLSRtQsSPLPQ
21 9 S498‑p RPLSRtQsSPLPQsP
0 1 S504‑p QsSPLPQsPQALQQL
0 2 K533‑ac QQQLQLGkILTKTGE
0 1 K533‑sm QQQLQLGkILTKTGE
0 9 T546‑p GELPRQPttHPEETE
0 4 T547‑p ELPRQPttHPEETEE
2 14 S611‑p VKDEEGEsGAEEGPD
1 34 S661‑p QALGRTQsSPAAPGG
0 4 S671‑p AAPGGMKsPPDQPVK
0 1 P673 PGGMKsPPDQPVKHL
2 1 S755‑p HTLLYGTsPLNRQKL
0 1 Y776‑p GPISQKMyAVLPCGG
0 1 S798‑p VWNEMHSssAVRMAV
0 1 S799‑p WNEMHSssAVRMAVG
0 1 N1040 AVLQQKPNINAVATL
0 1 S1059 EIQSKHWSCVQKFAA
0 2 S1071‑p FAAGLGRsLREAQAG
2 5 S1108‑p AAAAREHsPRPAEEP
3443 : Phospho-HDAC4 (Ser246)/HDAC5 (Ser259)/HDAC7 (Ser155) (D27B5) Rabbit mAb
3424 : Phospho-HDAC4 (Ser632)/HDAC5 (Ser498)/HDAC7 (Ser486) Antibody
  HDAC5 iso2  
S3 _____MNSPNESDGM
S7 _MNSPNESDGMSGRE
K35 IPVTVEVKPVLPRAM
S53 MGGGGGGSPSPVELR
S55 GGGGGSPSPVELRGA
S66 LRGALVGSVDPTLRE
T70 LVGSVDPTLREQQLQ
S180 SKESAIASTEVKLRL
T181 KESAIASTEVKLRLQ
S206 TPGGLNHSLPQHPKC
T234 PQSGPPGTPPSYKLP
S259 FPLRKTASEPNLKVR
S278 QKVAERRSSPLLRRK
S279 KVAERRSSPLLRRKD
T288 LLRRKDGTVISTFKK
S291 RKDGTVISTFKKRAV
T292 KDGTVISTFKKRAVE
S368 FSLYTSPSLPNISLG
S469 AVPLHGQSPLVTGER
T496 RHRPLSRTQSSPLPQ
S498 RPLSRTQSSPLPQSP
S504 QSSPLPQSPQALQQL
K533 QQQLQLGKILTKTGE
K533 QQQLQLGKILTKTGE
T546 GELPRQPTTHPEETE
T547 ELPRQPTTHPEETEE
S611 VKDEEGESGAEEGPD
S661 QALGRTQSSPAAPGG
S671 AAPGGMKSPPDQPVK
P673 PGGMKSPPDQPVKHL
- gap
Y691 GPISQKMYAVLPCGG
S713 VWNEMHSSSAVRMAV
S714 WNEMHSSSAVRMAVG
N955 AVLQQKPNINAVATL
S974 EIQSKHWSCVQKFAA
S986 FAAGLGRSLREAQAG
S1023 AAAAREHSPRPAEEP
  mouse

 
S3 _____MNSPNESDGM
S7 _MNSPNESDGMSGRE
K35 IPVAVEVKPVLPGAM
S53‑p MGGGGGGsPSPVELR
S55 GGGGGsPSPVELRGA
P66 LRGALAGPMDPALRE
A70 LAGPMDPALREQQLQ
S171 SKESAIASTEVKLRL
T172 KESAIASTEVKLRLQ
S197 TPGGLNHSLPQHPKC
T225 PQSGPPGTPPSYKLP
S250‑p FPLRKTAsEPNLKVR
S269‑p QKVAERRssPLLRRK
S270‑p KVAERRssPLLRRKD
T279 LLRRKDGTVISTFKK
S282 RKDGTVISTFKKRAV
T283 KDGTVISTFKKRAVE
S359 FSLYTSPSLPNISLG
S459 AVPLHGQSPLVTGER
T486‑p RHRPLSRtQsSPLPQ
S488‑p RPLSRtQsSPLPQSP
S494 QsSPLPQSPQALQQL
K523 QQQMQLGKILTKTGE
K523 QQQMQLGKILTKTGE
T536‑p GELSRQPtTHPEETE
T537 ELSRQPtTHPEETEE
S600‑p VKDEDGEsGPDEGPD
S650‑p QALGRTQsSPAAPGS
S660‑p AAPGSMKsPtDQPTV
T662‑p PGSMKsPtDQPTVVK
S746 HTLLYGTSPLNRQKL
Y767 GPISQKMYAMLPCGG
S789 VWNEMHSSSAVRMAV
S790 WNEMHSSSAVRMAVG
S1031‑p AVLQQKPsVNAVATL
S1050‑p EIQSKHWsCVQRFAA
S1062‑p FAAGLGCsLREAQTG
S1099 AVATQEHSPRPAEEP
3443 : Phospho-HDAC4 (Ser246)/HDAC5 (Ser259)/HDAC7 (Ser155) (D27B5) Rabbit mAb
3424 : Phospho-HDAC4 (Ser632)/HDAC5 (Ser498)/HDAC7 (Ser486) Antibody
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S4 ____AIASTEVKLRL
T5 ___AIASTEVKLRLQ
S30 TPGGLNHSLPQHPKC
T58 PQSGPPGTPPSYKLP
S83‑p FPLRKTAsEPNLKVR
S102 QKVAERRSsPLLRRK
S103‑p KVAERRSsPLLRRKD
T112 LLRRKDGTVISTFKK
S115 RKDGTVISTFKKRAV
T116 KDGTVISTFKKRAVE
S192 FSLYTSPSLPNISLG
S293 AVPLHGQSPLVTGER
T320 RHRPLSRTQsSPLPQ
S322‑p RPLSRTQsSPLPQSP
S328 QsSPLPQSPQALQQL
K357 QQQMQLGKILTKTGE
K357 QQQMQLGKILTKTGE
T370 GELSRQPTTHPEETE
T371 ELSRQPTTHPEETEE
S433‑p VKDEDGEsGPDEGAD
S483 QALGRTQSSPAAPGS
S493 AAPGSMKSPTDHPTV
T495 PGSMKSPTDHPTVER
S579 HTLLYGTSPLNRQKL
Y600 GPISQKMYAMLPCGG
S622 VWNEMHSSSAVRMAV
S623 WNEMHSSSAVRMAVG
S864 AVLQQKPSINAVATL
S883 EIQSKHWSCVQRFAT
S895 FATGLGCSLREAQTG
S932 AAATQEHSPRPAEEP
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