a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; Hydrolase; Nuclear receptor co-regulator; Deacetylase
Cellular Component: A band; actomyosin; cytoplasm; cytosol; histone deacetylase complex; neuromuscular junction; nucleoplasm; nucleus; transcriptional repressor complex; Z disc
Molecular Function: chromatin binding; histone deacetylase activity; histone deacetylase binding; NAD-dependent histone deacetylase activity (H3-K14 specific); potassium ion binding; protein binding; protein deacetylase activity; protein kinase binding; sequence-specific DNA binding; transcription activator binding; transcription corepressor activity; transcription factor binding; zinc ion binding
Biological Process: B cell activation; B cell differentiation; cardiac muscle hypertrophy; chromatin remodeling; histone deacetylation; inflammatory response; negative regulation of cell proliferation; negative regulation of glycolysis; negative regulation of osteoblast differentiation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; osteoblast development; positive regulation of cell proliferation; positive regulation of neuron apoptosis; positive regulation of protein sumoylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression, epigenetic; regulation of protein binding; regulation of skeletal muscle fiber development; response to denervation involved in regulation of muscle adaptation; response to drug; skeletal development; transcription, DNA-dependent
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.