Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
RASGRF1 (mouse)

RASGRF1 a guanine nucleotide exchange factor (GEF). Stimulates the dissociation of GDP from RAS protein. Activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit in the mouse brain,. The signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced variants have been reported. Note: This description may include information from UniProtKB.
Protein type: GEFs; GEFs, Ras
Cellular Component: apicolateral plasma membrane; basolateral plasma membrane; cell soma; cytoplasm; cytosol; growth cone
Molecular Function: glutamate receptor binding; protein binding; protein C-terminus binding; protein kinase binding; Ras GTPase binding; receptor tyrosine kinase binding
Biological Process: cell proliferation; neurite development; positive regulation of fibroblast proliferation; positive regulation of GTPase activity; positive regulation of Ras protein signal transduction; regulation of neuronal synaptic plasticity; regulation of Rac protein signal transduction; regulation of Ras protein signal transduction; regulation of synaptic plasticity
Reference #:  P27671 (UniProtKB)
Alt. Names/Synonyms: AI844718; Cdc25; CDC25Mm; GNRP; GRF beta; Grf1; Grfbeta; guanine nucleotide releasing factor 1; Guanine nucleotide-releasing protein; p190; P190-A; p190RhoGEF; Ras guanine release factor beta; RAS protein-specific guanine nucleotide-releasing factor 1; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25; Rasgrf1; RGRF1
Gene Symbols: Rasgrf1
Molecular weight: 144,102 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene