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Protein Page:
GAB1 (human)

Overview
GAB1 Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11. Interacts with HCK. Belongs to the GAB family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4q31.21
Cellular Component: cytosol
Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; SH3/SH2 adaptor activity
Biological Process: cell proliferation; epidermal growth factor receptor signaling pathway; insulin receptor signaling pathway; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade
Reference #:  Q13480 (UniProtKB)
Alt. Names/Synonyms: GAB1; GRB2-associated binder 1; GRB2-associated binding protein 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1
Gene Symbols: GAB1
Molecular weight: 76,616 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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GAB1

Protein Structure Not Found.
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