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Protein Page:
MEN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MEN1 Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms. Interacts with FANCD2 and DBF4. Interacts with JUND. Interacts with SMAD3, but not with SMAD2, nor SMAD4. Directly interacts with NFKB1, NFKB2 and RELA. Ubiquitous. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: chromatin; cleavage furrow; cytoplasm; cytosol; histone methyltransferase complex; nuclear chromatin; nuclear chromosome, telomeric region; nuclear matrix; nucleoplasm; nucleus; protein complex
Molecular Function: chromatin binding; double-stranded DNA binding; four-way junction DNA binding; histone-lysine N-methyltransferase activity; protein binding; protein binding, bridging; protein N-terminus binding; Y-form DNA binding
Biological Process: MAPKKK cascade; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of JNK cascade; negative regulation of osteoblast differentiation; negative regulation of protein amino acid phosphorylation; negative regulation of telomerase activity; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; osteoblast development; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta receptor signaling pathway; response to DNA damage stimulus; response to gamma radiation; response to UV
Disease: Multiple Endocrine Neoplasia, Type I
Reference #:  O00255 (UniProtKB)
Alt. Names/Synonyms: endocrine adenomatosis, multiple; MEAI; MEN1; Menin; multiple endocrine neoplasia I; SCG2
Gene Symbols: MEN1
Molecular weight: 68,023 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MEN1

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K4 ____MGLKAAQKTLF
0 1 K8 MGLKAAQKTLFPLRS
0 1 T215 NEDRRGQTVNAGVAE
0 1 K315‑ub HKGIASAkTYYRDEH
1 8 S399‑p EERPGEQsQGtQsQG
0 2 T402‑p PGEQsQGtQsQGSAL
0 1 S404‑p EQsQGtQsQGSALQD
0 1 T443‑p VLHVGWAtFLVQsLG
0 1 S448‑p WAtFLVQsLGRFEGQ
1 9 S492‑p RRGPRREsKPEEPPP
2 14 S548‑p QVPAPTAsPPPEGPV
1 1 S588 KLQLTAQSQVQMKKQ
1 0 K596 QVQMKKQKVStPSDY
0 11 T599‑p MKKQKVStPSDYTLS
0 1 K609‑ub DYTLSFLkRQRKGL_
  MEN1 iso2  
K4 ____MGLKAAQKTLF
K8 MGLKAAQKTLFPLRS
T210 NEDRRGQTVNAGVAE
K310 HKGIASAKTYYRDEH
S394‑p EERPGEQsQGTQSQG
T397 PGEQsQGTQSQGSAL
S399 EQsQGTQSQGSALQD
T438 VLHVGWATFLVQSLG
S443 WATFLVQSLGRFEGQ
S487‑p RRGPRREsKPEEPPP
S543‑p QVPAPTAsPPPEGPV
S583‑p KLQLTAQsQVQMKKQ
K591‑sm QVQMKKQkVSTPSDY
T594 MKKQkVSTPSDYTLS
K604 DYTLSFLKRQRKGL_
  mouse

 
K4‑ac ____MGLkAAQkTLF
K8‑ac MGLkAAQkTLFPLRS
T210‑p NEDRRGQtVNAGVAE
K310 HKGIASAKTYYQDEH
A394 EERTGEQAQGTQGQG
T397 TGEQAQGTQGQGSAL
G399 EQAQGTQGQGSALQD
T438 VLHVGWATFLVQSLG
S443 WATFLVQSLGRFEGQ
S487‑p RRGPRREsKPEEPPP
S544‑p QAPAPAAsPPPEGPV
S584 KLQLTAQSQVQMKKQ
K592 QVQMKKQKVSTPSDY
T595 MKKQKVSTPSDYTLS
K605 DYTLSFLKRQRKGL_
  rat

 
K4 ____MGLKAAQKTLF
K8 MGLKAAQKTLFPLRS
T210 NEDRRGQTVNAGVAE
K310 HKGIASAKTYYQDEH
A394 EERPGEQAQGTQGQG
T397 PGEQAQGTQGQGSAL
G399 EQAQGTQGQGSALQD
T438 VLHVGWATFLVQSLG
S443 WATFLVQSLGRFEGQ
S487 RRGPRRESKPEEPPP
S543‑p QAPAPAAsPPPEGPV
S583 KLQLTAQSQVQMKKQ
K591 QVQMKKQKVSTPSDY
T594 MKKQKVSTPSDYTLS
K604 DYTLSFLKRQRKGL_
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