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Protein Page:
FOXO3A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXO3A a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Oncoprotein; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus
Molecular Function: beta-catenin binding; chromatin DNA binding; DNA binding; protein binding; protein kinase binding; sequence-specific DNA binding; transcription factor activity
Biological Process: antral ovarian follicle growth; DNA damage response, signal transduction by p53 class mediator; glucose homeostasis; initiation of primordial ovarian follicle growth; negative regulation of transcription from RNA polymerase II promoter; oocyte maturation; ovulation from ovarian follicle; positive regulation of apoptosis; positive regulation of erythrocyte differentiation; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; regulation of translation; transcription from RNA polymerase II promoter; tumor necrosis factor-mediated signaling pathway
Reference #:  O43524 (UniProtKB)
Alt. Names/Synonyms: AF6q21; AF6q21 protein; DKFZp781A0677; FKHRL1; FKHRL1P2; forkhead box O3; forkhead box O3A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO2; FOXO3; FOXO3A; MGC12739; MGC31925
Gene Symbols: FOXO3
Molecular weight: 71,277 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  G1/S Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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FOXO3A

Protein Structure Not Found.
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Sites Implicated In
apoptosis, altered: S253‑p
apoptosis, induced: S574‑p
apoptosis, inhibited: S253‑p, S315‑p, S644‑p
carcinogenesis, induced: S253‑p
cell cycle regulation: S7‑p, S253‑p, S315‑p, S644‑p
cell growth, altered: S294‑p, S344‑p, S425‑p
cell growth, induced: S253‑p
transcription, altered: T32‑p, S253‑p
transcription, induced: S574‑p, S626‑p
transcription, inhibited: S253‑p, S315‑p, S574‑p, S644‑p
activity, inhibited: T32‑p, S253‑p, S294‑p, S344‑p, S425‑p, S644‑p
intracellular localization: S7‑p, T32‑p, S209‑p, S253‑p, S315‑p, S644‑p
molecular association, regulation: T32‑p, S209‑p, S253‑p, S294‑p, S344‑p, S425‑p, S626‑p
phosphorylation: S253‑p
protein degradation: S294‑p, S344‑p, S425‑p, S644‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 37 S7‑p _MAEAPAsPAPLsPL
1 31 S12‑p PAsPAPLsPLEVELD
0 1 S26‑p DPEFEPQsRPRsCtW
0 5 S30‑p EPQsRPRsCtWPLQR
60 97 T32‑p QsRPRsCtWPLQRPE
0 4 S43‑p QRPELQAsPAKPSGE
0 1 S48 QAsPAKPSGETAADS
0 1 S55 SGETAADSMIPEEED
0 1 S75‑p DGGGRAGsAMAIGGG
1 1 S90‑p GGSGTLGsGLLLEDS
0 1 S161‑p RNAWGNLsyADLITR
0 1 Y162‑p NAWGNLsyADLITRA
2 0 T179‑p SSPDKRLtLSQIyEW
0 8 Y184‑p RLtLSQIyEWMVRCV
4 0 S209‑p SSAGWKNsIRHNLsL
1 1 S215‑p NsIRHNLsLHSRFMR
1 0 S231‑p QNEGTGKssWWIINP
1 0 S232‑p NEGTGKssWWIINPD
3 0 K242‑ac IINPDGGksGkAPRR
1 0 S243‑p INPDGGksGkAPRRR
1 0 K245‑ac PDGGksGkAPRRRAV
24 86 S253‑p APRRRAVsMDNSNkY
3 1 K259‑ac VsMDNSNkYTKSRGR
2 0 K271‑ac RGRAAKKkAALQTAP
0 14 S280‑p ALQTAPEsADDsPsQ
1 23 S284‑p APEsADDsPsQLskW
0 3 S286‑p EsADDsPsQLskWPG
0 2 S289‑p DDsPsQLskWPGsPt
3 0 K290‑ac DsPsQLskWPGsPts
4 75 S294‑p QLskWPGsPtsRsSD
0 1 T296‑p skWPGsPtsRsSDEL
0 2 S297‑p kWPGsPtsRsSDELD
0 7 S299‑p PGsPtsRsSDELDAW
1 2 S300 GsPtsRsSDELDAWt
0 2 T307‑p SDELDAWtDFRsRTN
0 6 S311‑p DAWtDFRsRTNsNAs
4 1 S315‑p DFRsRTNsNAstVsG
8 1 S318‑p sRTNsNAstVsGRLS
0 1 T319‑p RTNsNAstVsGRLSP
7 0 S321‑p NsNAstVsGRLSPIM
2 1 S344‑p QDDDAPLsPMLYSSS
0 1 T395‑p DDLLDNItLPPsQPS
2 0 S399‑p DNItLPPsQPSPTGG
4 5 S413‑p GLMQRSSsFPYTTKG
0 1 G420 sFPYTTKGsGLGsPt
0 4 S421‑p FPYTTKGsGLGsPtS
4 7 S425‑p TKGsGLGsPtSSFNS
1 4 T427‑p GsGLGsPtSSFNSTV
0 1 S429 GLGsPtSSFNSTVFG
0 1 S432 sPtSSFNSTVFGPSs
0 1 T433 PtSSFNSTVFGPSsL
0 1 S439‑p STVFGPSsLNSLRQS
0 2 S551‑p LGGSRALsNSVsNMG
2 0 S555‑p RALsNSVsNMGLSES
2 0 K569‑ac SSSLGSAkHQQQsPV
3 0 S574‑p SAkHQQQsPVSQSMQ
2 0 S588‑p QTLSDSLsGSSLYST
3 0 S626‑p SLECDMEsIIRSELM
2 0 S644‑p GLDFNFDsLISTQNV
14724 : Phospho-FoxO3a (Ser7) Antibody
2599 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32)/FoxO4 (Thr28) (4G6) Rabbit mAb
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
9466 : Phospho-FoxO3a (Ser253) Antibody
13129 : Phospho-FoxO3a (Ser253) (D18H8) Rabbit mAb
5538 : Phospho-FoxO3a (Ser294) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
8174 : Phospho-FoxO3a (Ser413) (D77C9) Rabbit mAb
  mouse

 
S7‑p _MAEAPAsPVPLsPL
S12‑p PAsPVPLsPLEVELD
S26 DPEFEPQSRPRSCtW
S30 EPQSRPRSCtWPLQR
T32‑p QSRPRSCtWPLQRPE
S43‑p QRPELQAsPAKPsGE
S48‑p QAsPAKPsGETAADs
S55‑p sGETAADsMIPEEDD
S75 DGGGRASSAMVIGGG
S89‑p GVSSTLGsGLLLEDS
S160 RNAWGNLSYADLITR
Y161 NAWGNLSYADLITRA
T178 SSPDKRLTLSQIYEW
Y183 RLTLSQIYEWMVRCV
S208‑p SSAGWKNsIRHNLSL
S214 NsIRHNLSLHSRFMR
S230 QNEGTGKSSWWIINP
S231 NEGTGKSSWWIINPD
K241‑ac IINPDGGkSGKAPRR
S242 INPDGGkSGKAPRRR
K244 PDGGkSGKAPRRRAV
S252‑p APRRRAVsMDNSNkY
K258‑ac VsMDNSNkYTKSRGR
K270‑ac RGRAAKKkAALQAAP
S279‑p ALQAAPEsADDsPsQ
S283‑p APEsADDsPsQLSkW
S285‑p EsADDsPsQLSkWPG
S288 DDsPsQLSkWPGsPT
K289‑ac DsPsQLSkWPGsPTS
S293‑p QLSkWPGsPTSRssD
T295 SkWPGsPTSRssDEL
S296 kWPGsPTSRssDELD
S298‑p PGsPTSRssDELDAW
S299‑p GsPTSRssDELDAWT
T306 sDELDAWTDFRsRTN
S310‑p DAWTDFRsRTNsNAs
S314‑p DFRsRTNsNAsTVsG
S317‑p sRTNsNAsTVsGRLS
T318 RTNsNAsTVsGRLSP
S320‑p NsNAsTVsGRLSPIL
S343 QDDDGPLSPMLYSSS
A394 DDLLDNIALPPSQPS
S398 DNIALPPSQPSPPGG
S412‑p GLMQRGSsFPYTAKs
S419‑p sFPYTAKssGLGsPt
S420‑p FPYTAKssGLGsPtG
S424‑p AKssGLGsPtGsFNs
T426‑p ssGLGsPtGsFNstV
S428‑p GLGsPtGsFNstVFG
S431‑p sPtGsFNstVFGPSS
T432‑p PtGsFNstVFGPSSL
S438 stVFGPSSLNSLRQS
S550 LGGSRALSNSVSNMG
S554 RALSNSVSNMGLSDS
K568‑ac SSSLGSAkHQQQsPA
S573‑p SAkHQQQsPASQSMQ
S587 QTLSDSLSGSSLYSA
S625 SLECDMESIIRSELM
S643 GLDFNFDSLISTQNV
14724 : Phospho-FoxO3a (Ser7) Antibody
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
9466 : Phospho-FoxO3a (Ser253) Antibody
13129 : Phospho-FoxO3a (Ser253) (D18H8) Rabbit mAb
5538 : Phospho-FoxO3a (Ser294) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
  rat

 
S7‑p _MAEAPAsPVPLsPL
S12‑p PAsPVPLsPLEVELD
S26 DPEFEPQSRPRSCtW
S30 EPQSRPRSCtWPLQR
T32‑p QSRPRSCtWPLQRPE
S43 QRPELQASPAKPSGE
S48 QASPAKPSGETAADS
S55 SGETAADSMIPEEDD
S75 DSGGRGSSAMVIGGG
S89 GVSSALGSGLLLEDS
S160 RNAWGNLSYADLITR
Y161 NAWGNLSYADLITRA
T178 SSPDKRLTLSQIYEW
Y183 RLTLSQIYEWMVRCV
S208 SSAGWKNSIRHNLSL
S214 NSIRHNLSLHSRFMR
S230 QNEGTGKSSWWIINP
S231 NEGTGKSSWWIINPD
K241 IINPDGGKSGKAPRR
S242 INPDGGKSGKAPRRR
K244 PDGGKSGKAPRRRAV
S252‑p APRRRAVsMDNSNkY
K258‑ac VsMDNSNkYTKSRGR
K270 RGRAAKKKAALQAAP
S279 ALQAAPESADDsPSQ
S283‑p APESADDsPSQLSKW
S285 ESADDsPSQLSKWPG
S288 DDsPSQLSKWPGsPT
K289 DsPSQLSKWPGsPTS
S293‑p QLSKWPGsPTSRSSD
T295 SKWPGsPTSRSSDEL
S296 KWPGsPTSRSSDELD
S298 PGsPTSRSSDELDAW
S299 GsPTSRSSDELDAWT
T306 SDELDAWTDFRSRTN
S310 DAWTDFRSRTNSNAS
S314 DFRSRTNSNASTVSG
S317 SRTNSNASTVSGRLS
T318 RTNSNASTVSGRLSP
S320 NSNASTVSGRLSPIL
S343 QDDDGPLSPMLYSSS
A394 DDLLDNIALPPSQAS
S398 DNIALPPSQASPPGG
S412 GLMQRSSSFPYTAKS
S419 SFPYTAKSSGLGSPT
S420 FPYTAKSSGLGSPTS
S424 AKSSGLGSPTSSFNS
T426 SSGLGSPTSSFNSTV
S428 GLGSPTSSFNSTVFG
S431 SPTSSFNSTVFGPAS
T432 PTSSFNSTVFGPASL
S438 STVFGPASLNSLRQS
S550 LGGSRALSNSVSNMG
S554 RALSNSVSNMGLSDS
K568 SSSLGSAKHQQQSPV
S573 SAKHQQQSPVSQSMQ
S587 QTLSDSLSGSSLYSA
S625 SLECDMESIIRSELM
S643 GLDFNFDSLISTQNV
14724 : Phospho-FoxO3a (Ser7) Antibody
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
9466 : Phospho-FoxO3a (Ser253) Antibody
13129 : Phospho-FoxO3a (Ser253) (D18H8) Rabbit mAb
5538 : Phospho-FoxO3a (Ser294) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
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