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Protein Page:
GLI1 (human)

Overview
GLI1 Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. Interacts with KIF7. Interacts with ZIC1; the interaction enhances transcription activation. Amplified in glioblastoma cells. Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. Belongs to the GLI C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 12q13.2-q13.3
Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding
Biological Process: digestive tract morphogenesis; epidermal cell differentiation; osteoblast differentiation; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of smoothened signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of smoothened signaling pathway; smoothened signaling pathway
Reference #:  P08151 (UniProtKB)
Alt. Names/Synonyms: GLI; GLI family zinc finger 1; GLI1; Glioma-associated oncogene; glioma-associated oncogene family zinc finger 1; glioma-associated oncogene homolog 1 (zinc finger protein); Oncogene GLI; Zinc finger protein GLI1
Gene Symbols: GLI1
Molecular weight: 117,904 Da
Basal Isoelectric point: 6.98  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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GLI1

Protein Structure Not Found.
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