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Protein Page:
SUMO2 (human)

SUMO2 Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Broadly expressed. Belongs to the ubiquitin family. SUMO subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin-like modifier
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: nucleoplasm; nucleus; PML body
Molecular Function: protein binding; protein tag; ubiquitin protein ligase binding
Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein sumoylation
Reference #:  P61956 (UniProtKB)
Alt. Names/Synonyms: HSMT3; MGC117191; sentrin 2; Sentrin-2; small ubiquitin-like modifier 2; Small ubiquitin-related modifier 2; SMT3 homolog 2; SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); SMT3B; SMT3H2; SUMO-2; SUMO-3; SUMO2; SUMO3; Ubiquitin-like protein SMT3B
Gene Symbols: SUMO2
Molecular weight: 10,871 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling  |  NF-kB Signaling  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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