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Protein Page:
ME2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ME2 a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]
Protein type: EC 1.1.1.38; Oxidoreductase; Mitochondrial; Carbohydrate Metabolism - pyruvate
Chromosomal Location of Human Ortholog: 18q21
Cellular Component: intracellular membrane-bound organelle; mitochondrion
Molecular Function: electron carrier activity; malic enzyme activity
Disease: Epilepsy, Idiopathic Generalized; Opioid Dependence, Susceptibility To, 1
Reference #:  P23368 (UniProtKB)
Alt. Names/Synonyms: Malic enzyme 2; malic enzyme 2, NAD(+)-dependent, mitochondrial; MAOM; ME2; NAD-dependent malic enzyme, mitochondrial; NAD-ME; ODS1; pyruvic-malic carboxylase
Gene Symbols: ME2
Molecular weight: 65,444 Da
Basal Isoelectric point: 7.52  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ME2

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K24‑ac RHLHIKEkGKPLMLN
0 6 K94‑ac GIQERNEkLFYRILQ
0 1 S106‑p ILQDDIEsLMPIVYT
0 9 K156‑ac NWPENHVkAVVVTDG
0 1 Y175‑p GLGDLGVyGMGIPVG
0 1 Y222‑p DPFYMGLyQkRDRTQ
0 1 K224‑ac FYMGLyQkRDRTQQY
0 1 K224‑sc FYMGLyQkRDRTQQY
0 14 K240‑ac DLIDEFMkAITDRYG
0 1 K240‑sc DLIDEFMkAITDRYG
0 1 Y269‑p AFRFLRKyREkYCTF
0 5 K272‑ac FLRKyREkYCTFNDD
0 1 T283‑p FNDDIQGtAAVALAG
0 1 K339‑ac LSEQEAQkKIWMFDk
0 2 K346‑ac kKIWMFDkyGLLVKG
0 1 Y347‑p KIWMFDkyGLLVKGR
0 1 T400‑p AGAGRLFtPDVIRAM
0 1 T503‑p KALTSQLtDEELAQG
0 1 Y533‑p IAIKVTEyLYANKMA
0 1 Y543‑p ANKMAFRyPEPEDKA
  ME2 iso2  
K24 RHLHIKEKGKPLMLN
K94 GIQERNEKLFYRILQ
S106 ILQDDIESLMPIVYT
K156 NWPENHVKAVVVTDG
Y175 GLGDLGVYGMGIPVG
Y222 DPFYMGLYQKRDRTQ
K224 FYMGLYQKRDRTQQY
K224 FYMGLYQKRDRTQQY
K240 DLIDEFMKAITDRYG
K240 DLIDEFMKAITDRYG
Y269 AFRFLRKYREKYCTF
K272 FLRKYREKYCTFNDD
T283 FNDDIQGTAAVALAG
K339 LSEQEAQKKIWMFDK
K346 KKIWMFDKYGLLVKG
Y347 KIWMFDKYGLLVKGR
T400 AGAGRLFTPDVIRAM
- gap
- gap
- gap
  mouse

 
K24 RRVHLKEKGKPLMLN
K94 GIQERNEKLFYRILQ
S106 ILQDDIESLMPIVYT
K156 NWPENHVKAVVVTDG
Y175 GLGDLGVYGMGIPVG
Y222 DPFYMGLYQKRDRSQ
K224 FYMGLYQKRDRSQLY
K224 FYMGLYQKRDRSQLY
K240 DLMDEFMKAITDRYG
K240 DLMDEFMKAITDRYG
Y269 AFRFLRKYQQKYCTF
K272 FLRKYQQKYCTFNDD
T283 FNDDIQGTAAVALSG
R339 LSEEEAQRKIWMFDK
K346 RKIWMFDKSGLLVKG
S347 KIWMFDKSGLLVKGR
T400 AGAGPLFTHGVIKAM
T503 KALTTQLTDAELAQG
Y533 IAIKLAEYLYANKMA
Y543 ANKMAFRYPEPEDKA
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