Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
ME2 (human)

Overview
ME2 a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]
Protein type: Carbohydrate Metabolism - pyruvate; EC 1.1.1.38; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 18q21
Cellular Component: intracellular membrane-bound organelle; mitochondrion
Molecular Function: electron carrier activity; malic enzyme activity
Disease: Epilepsy, Idiopathic Generalized; Opioid Dependence, Susceptibility To, 1
Reference #:  P23368 (UniProtKB)
Alt. Names/Synonyms: Malic enzyme 2; malic enzyme 2, NAD(+)-dependent, mitochondrial; MAOM; ME2; NAD-dependent malic enzyme, mitochondrial; NAD-ME; ODS1; pyruvic-malic carboxylase
Gene Symbols: ME2
Molecular weight: 65,444 Da
Basal Isoelectric point: 7.52  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ME2

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB