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Protein Page:
EIF4E (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EIF4E a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex. Note: This description may include information from UniProtKB.
Protein type: Translation initiation; Translation
Chromosomal Location of Human Ortholog: 4q23
Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; mRNA cap complex; perinuclear region of cytoplasm; stress granule
Molecular Function: enzyme binding; eukaryotic initiation factor 4G binding; protein binding; RNA cap binding; translation initiation factor activity
Biological Process: G1/S transition of mitotic cell cycle; mRNA export from nucleus; poly(A) tail shortening; positive regulation of mitotic cell cycle; regulation of translation; RNA export from nucleus; translational initiation
Disease: Autism, Susceptibility To, 19
Reference #:  P06730 (UniProtKB)
Alt. Names/Synonyms: CBP; eIF-4E; eIF-4F 25 kDa subunit; EIF4E; EIF4E1; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eukaryotic translation initiation factor 4E-like 1; IF4E; MGC111573; mRNA cap-binding protein
Gene Symbols: EIF4E
Molecular weight: 25,097 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Insulin Receptor Signaling  |  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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EIF4E

Protein Structure Not Found.
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Sites Implicated In
cell growth, altered: S209, T210
cell growth, induced: S209
translation, induced: S209
molecular association, regulation: S209

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T3 _____MAtVEPETtP
0 3 T9 AtVEPETtPtPNPPt
0 1 T11 VEPETtPtPNPPttE
0 1 T16 tPtPNPPttEEEKtE
0 1 T17 PtPNPPttEEEKtEs
0 1 T22 PttEEEKtEsNQEVA
0 5 S24 tEEEKtEsNQEVANP
2 0 S53 WFFKNDKsKTWQANL
0 2 Y183 VTHIGRVyKERLGLP
0 1 T203 GYQSHADtATKsGst
0 1 S207 HADtATKsGsttKNR
49 4 S209 DtATKsGsttKNRFV
3 2 T210 tATKsGsttKNRFVV
0 1 T211 ATKsGsttKNRFVV_
9741 : Phospho-eIF4E (Ser209) Antibody
  EIF4E iso4  
- gap
T37 LRESQETTPTPNPPT
T39 ESQETTPTPNPPTTE
T44 TPTPNPPTTEEEKTE
T45 PTPNPPTTEEEKTES
T50 PTTEEEKTESNQEVA
S52 TEEEKTESNQEVANP
S81 WFFKNDKSKTWQANL
Y211 VTHIGRVYKERLGLP
T231 GYQSHADTATKSGST
S235 HADTATKSGSTTKNR
S237 DTATKSGSTTKNRFV
T238 TATKSGSTTKNRFVV
T239 ATKSGSTTKNRFVV_
  mouse

 
T3 _____MATVEPETTP
T9 ATVEPETTPTTNPPP
T11 VEPETTPTTNPPPAE
P16 TPTTNPPPAEEEKTE
A17 PTTNPPPAEEEKTEs
T22 PPAEEEKTEsNQEVA
S24 AEEEKTEsNQEVANP
S53 WFFKNDKSKTWQANL
Y183 VTHIGRVYKERLGLP
T203 GYQSHADTATKSGst
S207 HADTATKSGsttKNR
S209 DTATKSGsttKNRFV
T210 TATKSGsttKNRFVV
T211 ATKSGsttKNRFVV_
9741 : Phospho-eIF4E (Ser209) Antibody
  rat

 
T3 _____MATVEPETTP
T9 ATVEPETTPTTNPPP
T11 VEPETTPTTNPPPAE
P16 TPTTNPPPAEEEKTE
A17 PTTNPPPAEEEKTES
T22 PPAEEEKTESNQEVA
S24 AEEEKTESNQEVANP
S53 WFFKNDKSKTWQANL
Y183 VTHIGRVyKERLGLP
T203 GYQSHADTATKSGsT
S207 HADTATKSGsTTKNR
S209 DTATKSGsTTKNRFV
T210 TATKSGsTTKNRFVV
T211 ATKSGsTTKNRFVV_
9741 : Phospho-eIF4E (Ser209) Antibody
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