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Protein Page:
RALB (human)

RALB Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. Interacts with EXOC2 and EXOC8. Interacts with RALBP1 via its effector domain. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras
Chromosomal Location of Human Ortholog: 2q14.2
Cellular Component: autophagic vacuole; exocyst; midbody; plasma membrane
Molecular Function: ATPase binding; GDP binding; GTP binding; GTPase activity; protein binding; ubiquitin protein ligase binding
Biological Process: cellular response to starvation; cytokinesis; negative regulation of protein binding; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; regulation of exocyst assembly; regulation of exocyst localization; signal transduction
Reference #:  P11234 (UniProtKB)
Alt. Names/Synonyms: GTP binding protein; GTP binding protein); RALB; RAS-like protein B; Ras-related protein Ral-B; v-ral simian leukemia viral oncogene homolog B (ras related
Gene Symbols: RALB
Molecular weight: 23,409 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
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