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Protein Page:
SMC2L1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMC2L1 Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Belongs to the SMC family. SMC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 9q31.1
Cellular Component: condensed chromosome; condensin complex; cytoplasm; cytosol; nuclear chromosome; nucleolus; nucleoplasm; nucleus
Molecular Function: ATP binding; protein binding; protein heterodimerization activity
Biological Process: cell division; kinetochore organization and biogenesis; meiotic chromosome condensation; meiotic chromosome segregation; mitotic cell cycle; mitotic chromosome condensation
Reference #:  O95347 (UniProtKB)
Alt. Names/Synonyms: CAP-E; CAPE; Chromosome-associated protein E; FLJ10093; hCAP-E; SMC protein 2; SMC-2; SMC2; SMC2 (structural maintenance of chromosomes 2, yeast)-like 1; SMC2 structural maintenance of chromosomes 2-like 1; SMC2L1; structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E; structural maintenance of chromosomes 2; Structural maintenance of chromosomes protein 2; XCAP-E homolog
Gene Symbols: SMC2
Molecular weight: 135,656 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMC2L1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 K12‑ub SIILEGFkSYAQRTE
0 5 S60‑p NLSQVRAsNLQDLVy
0 1 Y67‑p sNLQDLVykNGQAGI
0 10 K68‑ub NLQDLVykNGQAGIT
0 1 K114‑ac VVIGGRNkYLINGVN
0 3 K114‑ub VVIGGRNkYLINGVN
0 1 K152‑ub IMQGRITkVLNMKPP
0 1 K196 EAKLKEIKTILEEEI
0 1 K209 EITPTIQKLKEERSS
0 1 K211 TPTIQKLKEERSSYL
0 1 K222‑ac SSYLEYQkVMREIEH
0 1 K222‑ub SSYLEYQkVMREIEH
0 1 Y237 LSRLYIAYQFLLAED
0 1 S249‑p AEDTKVRsAEELKEM
0 1 S268‑p IKLQEELsENDKKIK
0 1 K290‑ub ELEKRKDkEtGGILR
0 1 T292‑p EKRKDkEtGGILRSL
0 8 K320‑ac SQSAFDLkkKNLACE
0 1 K320‑sc SQSAFDLkkKNLACE
0 1 K321‑ac QSAFDLkkKNLACEE
0 38 K330‑ac NLACEESkRKELEkN
0 1 K336‑ac SkRKELEkNMVEDSK
0 2 N337 kRKELEkNMVEDSKT
0 2 S342 EkNMVEDSKTLAAkE
0 2 K343 kNMVEDSKTLAAkEK
0 1 K348‑ac DSKTLAAkEKEVkKI
0 2 K348 DSKTLAAKEKEVkKI
0 1 K353‑ac AAkEKEVkKITDGLH
0 1 K455 QEALEAVKRLKEKLE
0 1 R456 EALEAVKRLKEKLEA
0 1 K474 KLNYEENKEEsLLEK
0 1 S477‑p YEENKEEsLLEKRRQ
0 1 S477 YEENKEESLLEKRRQ
0 2 S486‑p LEKRRQLsRDIGRLK
0 1 K511‑ub PNLRFAYkDPEKNWN
0 1 K523‑ub NWNRNCVkGLVASLI
0 1 K562‑ub DTEVTGKkLLERGEL
0 3 T574‑p GELKRRYtIIPLNKI
0 2 K677‑ac QAASILTkFQELkDV
0 1 K677‑ub QAASILTkFQELkDV
0 1 K682‑ub LTkFQELkDVQDELR
0 1 K768‑ac NTKEIQRkAEEKYEV
0 1 Y773 QRkAEEKYEVLENKM
0 1 K792‑ac AERERELkDAQKKLD
0 1 K813‑ac DASSKKMkEKQQEVE
0 1 K837‑ac KREHTSYkQQLEAVN
0 4 Y850 VNEAIKSYESQIEVM
0 1 K911‑ub NDSQLKIkELDHNIS
0 1 K958‑ac PNSAYDFkTNNPkEA
0 1 K958‑ub PNSAYDFkTNNPkEA
0 1 K963‑ac DFkTNNPkEAGQRLQ
0 1 K971‑ac EAGQRLQkLQEMKEK
0 1 T1017‑p NDKSKILttIEDLDQ
0 1 T1018‑p DKSKILttIEDLDQk
0 2 K1025‑ub tIEDLDQkkNQALNI
0 1 K1026‑ub IEDLDQkkNQALNIA
0 1 K1036‑ub ALNIAWQkVNKDFGS
0 1 K1079‑ub VALGNTWkENLTELS
0 2 K1158‑ac NNANVLFktkFVDGV
0 1 T1159‑p NANVLFktkFVDGVS
0 2 K1160‑ac ANVLFktkFVDGVST
0 2 K1160‑ub ANVLFktkFVDGVST
0 1 K1178‑ub FTQCQNGkISKEAKS
  SMC2L1 iso2  
K12 SIILEGFKSYAQRTE
S60 NLSQVRASNLQDLVY
Y67 SNLQDLVYKNGQAGI
K68 NLQDLVYKNGQAGIT
K114 VVIGGRNKYLINGVN
K114 VVIGGRNKYLINGVN
K152 IMQGRITKVLNMKPP
K196 EAKLKEIKTILEEEI
K209 EITPTIQKLKEERSS
K211 TPTIQKLKEERSSYL
K222 SSYLEYQKVMREIEH
K222 SSYLEYQKVMREIEH
Y237 LSRLYIAYQFLLAED
S249 AEDTKVRSAEELKEM
S268 IKLQEELSENDKKIK
K290 ELEKRKDKETGGILR
T292 EKRKDKETGGILRSL
K320 SQSAFDLKKKNLACE
K320 SQSAFDLKKKNLACE
K321 QSAFDLKKKNLACEE
K330 NLACEESKRKELEKN
K336 SKRKELEKNMVEDSK
N337 KRKELEKNMVEDSKT
S342 EKNMVEDSKTLAAKE
K343 KNMVEDSKTLAAKEK
K348 DSKTLAAKEKEVKKI
K348 DSKTLAAKEKEVKKI
K353 AAKEKEVKKITDGLH
K455 QEALEAVKRLKEKLE
R456 EALEAVKRLKEKLEA
K474 KLNYEENKEESLLEK
S477 YEENKEESLLEKRRQ
S477 YEENKEESLLEKRRQ
S486 LEKRRQLSRDIGRLK
K511 PNLRFAYKDPEKNWN
K523 NWNRNCVKGLVASLI
K562 DTEVTGKKLLERGEL
T574 GELKRRYTIIPLNKI
K677 QAASILTKFQELKDV
K677 QAASILTKFQELKDV
K682 LTKFQELKDVQDELR
K768 NTKEIQRKAEEKYEV
Y773 QRKAEEKYEVLENKM
K792 AERERELKDAQKKLD
K813 DASSKKMKEKQQEVE
K837 KREHTSYKQQLEAVN
Y850 VNEAIKSYESQIEVM
K911 NDSQLKIKELDHNIS
K958 PNSAYDFKTNNPKEA
K958 PNSAYDFKTNNPKEA
K963 DFKTNNPKEAGQRLQ
K971 EAGQRLQKLQEMKEK
T1017 NDKSKILTTIEDLDQ
T1018 DKSKILTTIEDLDQK
K1025 TIEDLDQKKNQALNI
K1026 IEDLDQKKNQALNIA
K1036 ALNIAWQKVNKDFGS
K1079 VALGNTWKENLTELS
- gap
- gap
- gap
- gap
- gap
  mouse

 
K12 SIILEGFKSYAQRTE
S60 NLSQVRASNLQDLVY
Y67 SNLQDLVYKNGQAGI
K68 NLQDLVYKNGQAGIT
K114 VVIGGRNKYLINGVN
K114 VVIGGRNKYLINGVN
K152 IMQGRITKVLNMKPP
K196‑ac EAKLKEIkTILEEEI
K209‑ac EITPTIQkLkEERSS
K211‑ac TPTIQkLkEERSSYL
K222 SSYLEYQKVMREIEH
K222 SSYLEYQKVMREIEH
Y237‑p LSRLYIAyQFLRAED
S249 AEDTKERSAGELKEM
S268 VNLQEVLSENEKKIK
K290 ELERRKDKETGGKLK
T292 ERRKDKETGGKLKSL
K320‑ac SQSAFDLkKKNLASE
K320 SQSAFDLKKKNLASE
K321 QSAFDLkKKNLASEE
K330 NLASEETKRKELQNs
N336 TKRKELQNsMAEDsK
S337‑p KRKELQNsMAEDsKA
S342‑p QNsMAEDsKALAAKE
K343 NsMAEDsKALAAKEK
K348 DsKALAAKEKEVKKI
K348 DsKALAAKEKEVKKI
K353 AAKEKEVKKITDGLH
K455‑ac QDAFEAVkkAKEKLE
K456‑ac DAFEAVkkAKEKLET
K474‑ub KLNYEENkEEkLLEK
K477 YEENkEEKLLEKHRQ
K477‑ub YEENkEEkLLEKHRQ
S486‑p LEKHRQLsRDINNLK
K511 PNLQFAYKDPEKNWN
K523 NWNRNSVKGLVASLI
K562 DTEVTAKKLLEKGEL
T574‑p GELKRRYtIIPLNKI
K677 QAASILTKFQEVKDV
K677 QAASILTKFQEVKDV
K682 LTKFQEVKDVQDELR
K768 STKEIQKKAEEKyEA
Y773‑p QKKAEEKyEALENKM
K792 AEREKELKDAQKKLD
K813 DASSKKMKEKQQEVE
E837 KREHASNEQQLDAVN
Y850 VNEAIKAYEGQIEKM
K911 NESQLKIKELDHSIS
K958 PNSAYDFKTNNPKEA
K958 PNSAYDFKTNNPKEA
K963 DFKTNNPKEAGQRLQ
K971 EAGQRLQKLQEVKEK
A1017 NDKSKILATIEDLDQ
T1018 DKSKILATIEDLDQK
K1025 TIEDLDQKKNQALNI
K1026 IEDLDQKKNQALNIA
K1036 ALNIAWQKVNKDFGS
K1079 VALGNTWKENLTELS
K1158 NNANVLFKTKFVDGV
T1159 NANVLFKTKFVDGVS
K1160 ANVLFKTKFVDGVST
K1160 ANVLFKTKFVDGVST
K1178 FTQSQAGKIPKEAKS
  rat

 
K12 SIILEGFKSYAQRTE
S60 NLSQVRASNLQDLVY
Y67 SNLQDLVYKNGQAGI
K68 NLQDLVYKNGQAGIT
K114 VVIGGRNKYLINGVN
K114 VVIGGRNKYLINGVN
K152 IMQGRITKVLNMKPP
K196 EAKLKEIKTILEEEI
K209 EITPTIQKLKEERSS
K211 TPTIQKLKEERSSYL
K222 SSYLEYQKVMREIEH
K222 SSYLEYQKVMREIEH
Y237 LSRLYIAYQFLLAED
S249 AEDTKERSAGELKEM
S268 LKLQEVLSENEKKIK
K290 ELEKRKDKETGGILR
T292 EKRKDKETGGILRSL
K320 SQSAFDLKKKNLASE
K320 SQSAFDLKKKNLASE
K321 QSAFDLKKKNLASEE
K330 NLASEETKRKELEKN
K336 TKRKELEKNMAEDSk
N337 KRKELEKNMAEDSkA
S342 EKNMAEDSkALAAkE
K343‑ub KNMAEDSkALAAkEK
K348 DSkALAAKEKEVKKL
K348‑ub DSkALAAkEKEVKKL
K353 AAkEKEVKKLTDGLH
K455 QEAFEAVKKVKEKLE
K456 EAFEAVKKVKEKLET
K474 KLNYEDNKEERLLEK
R477 YEDNKEERLLEKHRQ
R477 YEDNKEERLLEKHRQ
S486 LEKHRQVSRDISNLK
K511 PNLRFAYKDPEKNWN
K523 NWNRNCVKGLVASLI
K562 DTEVTGKKLLEKGEL
T574 GELKRRYTIIPLNKI
K677 QAASILTKFQELKDV
K677 QAASILTKFQELKDV
K682 LTKFQELKDVQAELR
K768 NTKEIQKKAEEKYEA
Y773 QKKAEEKYEALENKM
K792 AEREKELKDAQKKLD
K813 DASSKKMKEKQQEVE
E837 KREHASNEQQLDAVN
Y850‑p VNEAIKAyEGQIEIM
K911 NDSQLKIKELDHSIS
K958 PNSAYDFKTNNPKEA
K958 PNSAYDFKTNNPKEA
K963 DFKTNNPKEAGQRLQ
K971 EAGQRLQKLQEVKEK
A1017 NDKSKILATIEDLDQ
T1018 DKSKILATIEDLDQK
K1025 TIEDLDQKKNQALNI
K1026 IEDLDQKKNQALNIA
K1036 ALNIAWQKVNKDFGS
K1079 VALGNTWKENLTELS
K1158 NNANVLFKTKFVDGV
T1159 NANVLFKTKFVDGVS
K1160 ANVLFKTKFVDGVST
K1160 ANVLFKTKFVDGVST
R1178 FTQSQNGRIPKEAKA
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