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Protein Page:
DFFA (human)

DFFA Inhibitor of the caspase-activated DNase (DFF40). Heterodimer of DFFA and DFFB. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hydrolase
Chromosomal Location of Human Ortholog: 1p36.3-p36.2
Cellular Component: cytoplasm; cytosol; lipid particle; nuclear chromatin; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: DNA fragmentation during apoptosis
Reference #:  O00273 (UniProtKB)
Alt. Names/Synonyms: DFF-45; DFF1; DFF45; DFFA; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; ICAD; Inhibitor of CAD
Gene Symbols: DFFA
Molecular weight: 36,522 Da
Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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