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Protein Page:
TLR8 (human)

Overview
TLR8 Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp22
Cellular Component: endoplasmic reticulum membrane; endosome membrane; Golgi membrane; integral to membrane
Molecular Function: DNA binding; double-stranded RNA binding; drug binding; receptor activity; RNA binding; single-stranded RNA binding
Biological Process: defense response to virus; I-kappaB kinase/NF-kappaB cascade; immunoglobulin mediated immune response; inflammatory response; innate immune response; microglial cell activation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of innate immune response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-8 biosynthetic process; regulation of cytokine secretion; regulation of protein amino acid phosphorylation; response to virus; toll-like receptor 8 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Reference #:  Q9NR97 (UniProtKB)
Gene Symbols: TLR8
Molecular weight: 119,828 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TLR8

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y64 VPQTVGKYVTELDLS
0 1 T66 QTVGKYVTELDLSDN
0 1 S345‑p RLEILDLsFNyIKGS
0 1 Y348‑p ILDLsFNyIKGSYPQ
0 1 S368‑p RNFSKLLsLRALHLR
0 1 T762‑p ALETKTTtKLsMLEL
0 1 S765‑p TKTTtKLsMLELHGN
1 0 Y880‑p LSTSQTFyDAYISyD
1 0 Y886‑p FyDAYISyDTKDASV
0 1 S935‑p IIDNLMQsINQsKKT
0 1 S939‑p LMQsINQsKKTVFVL
1 0 Y1030‑p LTENDSRyNNMYVDS
  mouse

 
Y64‑p VPQTIGKyVtNIDLS
T66‑p QTIGKyVtNIDLSDN
S340 SLQILDLSFNFQYKE
F343 ILDLSFNFQYKEYLQ
S363 SNFSKLRSLKKLHLR
T753 SLQTKMKTNLSILEL
S756 TKMKTNLSILELHGN
Y871 SSTSQTFYDAYISYD
Y877 FYDAYISYDTKDASV
S926 IIDNLMQSINQSKKT
S930 LMQSINQSKKTIFVL
Y1021 LTENDSRYDDLYIDS
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