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Protein Page:
AID (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AID Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; EC 3.5.4.38
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: cytoplasm; exosome (RNase complex); nucleus
Molecular Function: cytidine deaminase activity; protein binding; ubiquitin protein ligase binding
Biological Process: somatic diversification of immunoglobulins; somatic hypermutation of immunoglobulin genes
Disease: Immunodeficiency With Hyper-igm, Type 2
Reference #:  Q9GZX7 (UniProtKB)
Alt. Names/Synonyms: Activation-induced cytidine deaminase; AICDA; AID; ARP2; CDA2; Cytidine aminohydrolase; HIGM2; integrated into Burkitt's lymphoma cell line Ramos
Gene Symbols: AICDA
Molecular weight: 23,954 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AID

Protein Structure Not Found.
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Sites Implicated In
cell cycle regulation: S3‑p
enzymatic activity, induced: T27‑p, S38‑p
enzymatic activity, inhibited: T27‑p
protein degradation: S3‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 S3‑p _____MDsLLMNRRK
5 2 T27‑p WAKGRREtYLCYVVK
11 3 S38‑p YVVKRRDsATsFsLD
1 3 S41‑p KRRDsATsFsLDFGy
1 2 S43‑p RDsATsFsLDFGyLR
0 1 Y48‑p sFsLDFGyLRNKNGC
3 0 T140 GVQIAIMTFKDYFYC
0 1 Y146 MTFKDYFYCWNTFVE
0 1 K160‑ac ENHERTFkAWEGLHE
1 2 Y184 RRILLPLYEVDDLRD
  mouse

 
S3‑p _____MDsLLMKQKK
T27‑p WAKGRHEtYLCYVVK
S38‑p YVVKRRDsATsCSLD
S41‑p KRRDsATsCSLDFGH
S43 RDsATsCSLDFGHLR
H48 sCSLDFGHLRNKSGC
T140‑p GVQIGIMtFKDYFYC
Y146 MtFKDYFYCWNTFVE
K160 ENRERTFKAWEGLHE
Y184‑p RRILLPLyEVDDLRD
  rat

 
- gap
- gap
S9 YVVKRRDSATSFSLD
S12 KRRDSATSFSLDFGH
S14 RDSATSFSLDFGHLR
H19 SFSLDFGHLRNKSGC
T111 GVQIGIMTFKDYFyC
Y117‑p MTFKDYFyCWNTFVE
K131 ENHERTFKAWEGLHE
Y155 RRILLPLYEVDDLRD
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