an integral membrane protein of the connexin family, alpha-type (group II) subfamily. Hexamers of connexin-43 form connexons, which aggregate together to form gap junctions, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Note: This description may include information from UniProtKB.
Cellular Component: connexon complex; endoplasmic reticulum membrane; focal adhesion; gap junction; Golgi apparatus; Golgi membrane; integral to plasma membrane; lipid raft; mitochondrion; plasma membrane
Molecular Function: gap junction channel activity; ion transmembrane transporter activity; protein binding; signal transducer activity
Biological Process: cell-cell signaling; gap junction assembly; muscle contraction; negative regulation of cell growth; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction; transport