Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. Belongs to the nuclear hormone receptor family. NR1 subfamily. Note: This description may include information from UniProtKB.
Molecular Function: DNA binding; drug binding; ligand-dependent nuclear receptor activity; lipid binding; protein binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; transcription factor binding; ubiquitin conjugating enzyme binding
Biological Process: cellular lipid metabolic process; circadian regulation of gene expression; fatty acid transport; lipid metabolic process; negative regulation of appetite; negative regulation of glycolysis; negative regulation of inflammatory response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of fatty acid beta-oxidation; positive regulation of fatty acid oxidation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of circadian rhythm; transcription initiation from RNA polymerase II promoter