a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors.. Seems to activate the transcription of growth-related genes. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus; Oncoprotein; Transcription factor
Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; protein complex
Molecular Function: DNA binding; protein binding; protein complex binding; transcription activator binding; transcription factor activity; transcription factor binding
Biological Process: cell cycle arrest; cellular iron ion homeostasis; chromatin remodeling; chromosome organization and biogenesis; G1/S transition of mitotic cell cycle; MAPKKK cascade; negative regulation of apoptosis; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of caspase activity; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein deubiquitination; protein-DNA complex disassembly; regulation of gene expression; regulation of telomere maintenance; regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; response to drug; response to gamma radiation; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin