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Protein Page:
K18 (human)

Overview
K18 a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 18 and its filament partner keratin 8 are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Defects are a cause of cryptogenic cirrhosis. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Nucleolus
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: cell-cell adherens junction; cytoplasm; intermediate filament; keratin filament; microtubule organizing center
Molecular Function: protein binding
Biological Process: anatomical structure morphogenesis; Golgi to plasma membrane CFTR protein transport; intermediate filament cytoskeleton organization and biogenesis; negative regulation of apoptosis
Disease: Cirrhosis, Familial
Reference #:  P05783 (UniProtKB)
Alt. Names/Synonyms: Cell proliferation-inducing gene 46 protein; cell proliferation-inducing protein 46; CK-18; CYK18; cytokeratin 18; Cytokeratin-18; K18; K1C18; keratin 18; Keratin, type I cytoskeletal 18; Keratin-18; KRT18
Gene Symbols: KRT18
Molecular weight: 48,058 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

K18

Protein Structure Not Found.


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