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Protein Page:
Jun (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Jun the protooncogene c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The Jun Kinases (JNKs) binds to the N-terminal region of c-Jun and phosphorylate it in response to extracellular signals including growth factors, cytokines and stress, regulating its transcriptional activity. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 1p32-p31
Cellular Component: cytosol; nuclear chromosome; nucleoplasm; nucleus; transcription factor complex; transcriptional repressor complex
Molecular Function: chromatin binding; DNA binding; enzyme binding; GTPase activator activity; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: aging; angiogenesis; axon regeneration; cellular response to hormone stimulus; cellular response to potassium ion starvation; circadian rhythm; leading edge cell differentiation; learning; liver development; membrane depolarization; microglial cell activation; monocyte differentiation; negative regulation of cell proliferation; negative regulation of DNA binding; negative regulation of neuron apoptosis; negative regulation of protein amino acid autophosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of cell differentiation; positive regulation of DNA replication; positive regulation of endothelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of GTPase activity; positive regulation of monocyte differentiation; positive regulation of neuron apoptosis; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; regulation of cell cycle; regulation of cell proliferation; regulation of transcription factor activity; release of cytochrome c from mitochondria; response to cAMP; response to cytokine stimulus; response to drug; response to hydrogen peroxide; response to lipopolysaccharide; response to mechanical stimulus; response to radiation; SMAD protein nuclear translocation; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway
Reference #:  P05412 (UniProtKB)
Alt. Names/Synonyms: Activator protein 1; AP-1; AP1; c-Jun; enhancer-binding protein AP1; JUN; Jun activation domain binding protein; jun oncogene; p39; Proto-oncogene c-Jun; Transcription factor AP-1; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
Gene Symbols: JUN
Molecular weight: 35,676 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Jun

Protein Structure Not Found.
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Sites Implicated In
apoptosis, altered: S63‑p, T95‑p
apoptosis, induced: S63‑p
carcinogenesis, altered: T2‑p, T8‑p, T89‑p, T93‑p, T286‑p
cell growth, altered: T2‑p, T8‑p, S63‑p, S73‑p, T89‑p, T93‑p, T286‑p
cell motility, induced: S63‑p, S73‑p
cell motility, inhibited: T239‑p
transcription, altered: S63‑p, S73‑p, T91‑p, T93‑p, T95‑p, T231‑p, S243‑p, S249‑p
transcription, induced: S63‑p, S73‑p
transcription, inhibited: T239‑p
activity, induced: S63‑p, S73‑p, T95‑p
activity, inhibited: T231‑p, S243‑p, S249‑p
molecular association, regulation: S63‑p, S73‑p, T91‑p, T93‑p, Y170‑p, T231‑p, T239‑p, S243‑p, S249‑p
phosphorylation: S243‑p
protein stabilization: S63‑p, S73‑p
ubiquitination: T239‑p, S243‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T2‑p ______MtAKMETtF
1 0 T8‑p MtAKMETtFYDDALN
0 1 S37‑p NPKILKQsMTLNLAD
0 1 S48‑p NLADPVGsLkPHLRA
0 1 K50‑ub ADPVGsLkPHLRAKN
0 1 K56 LkPHLRAKNsDLLts
0 13 S58‑p PHLRAKNsDLLtsPD
0 10 T62‑p AKNsDLLtsPDVGLL
107 40 S63‑p KNsDLLtsPDVGLLK
71 68 S73‑p VGLLKLAsPELERLI
0 1 S83 LERLIIQSSNGHItT
0 1 S84 ERLIIQSSNGHItTt
1 0 T89‑p QSSNGHItTtPtPtQ
7 1 T91‑p SNGHItTtPtPtQFL
8 1 T93‑p GHItTtPtPtQFLCP
1 1 T95‑p ItTtPtPtQFLCPKN
2 1 Y170‑p LHSEPPVyANLSNFN
5 0 K226‑sm HPRLQALkEEPQtVP
3 0 T231‑p ALkEEPQtVPEMPGE
6 24 T239‑p VPEMPGEtPPLsPID
10 33 S243‑p PGEtPPLsPIDMEsQ
3 2 S249‑p LsPIDMEsQERIkAE
2 0 K254‑sm MEsQERIkAERKRMR
1 0 K268‑ac RNRIAASkCRkRkLE
2 0 K271‑ac IAASkCRkRkLERIA
1 0 K273‑ac ASkCRkRkLERIARL
1 1 T286‑p RLEEKVKtLKAQNSE
0 1 K309‑ub REQVAQLkQKVMNHV
2361 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb
2363 : Phospho-c-Jun (Ser63) (58A6) Mouse mAb
5464 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb (Biotinylated)
9261 : Phospho-c-Jun (Ser63) II Antibody
3270 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb
8752 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (PE Conjugate)
9164 : Phospho-c-Jun (Ser73) Antibody
12714 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2303 : Phospho-c-Jun (Thr91) Antibody
2993 : Phospho-c-Jun (Thr93) Antibody
2994 : Phospho-c-Jun (Ser243) Antibody
  mouse

 
T2 ______MTAKMETTF
T8 MTAKMETTFYDDALN
S37 NPKILKQSMTLNLAD
S48 NLADPVGSLKPHLRA
K50 ADPVGSLKPHLRAkN
K56‑ub LKPHLRAkNsDLLts
S58‑p PHLRAkNsDLLtsPD
T62‑p AkNsDLLtsPDVGLL
S63‑p kNsDLLtsPDVGLLK
S73‑p VGLLKLAsPELERLI
S83‑p LERLIIQssNGHITT
S84‑p ERLIIQssNGHITTt
T89 QssNGHITTtPtPtQ
T91‑p sNGHITTtPtPtQFL
T93‑p GHITTtPtPtQFLCP
T95‑p ITTtPtPtQFLCPKN
Y170 LHSEPPVYANLSNFN
K229‑sm HPRLQALkEEPQTVP
T234 ALkEEPQTVPEMPGE
T242‑p VPEMPGEtPPLsPID
S246‑p PGEtPPLsPIDMESQ
S252 LsPIDMESQERIkAE
K257‑sm MESQERIkAERKRMR
K271 RNRIAASKCRKRKLE
K274 IAASKCRKRKLERIA
K276 ASKCRKRKLERIARL
T289 RLEEKVKTLKAQNSE
K312 REQVAQLKQKVMNHV
2361 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb
2363 : Phospho-c-Jun (Ser63) (58A6) Mouse mAb
5464 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb (Biotinylated)
9261 : Phospho-c-Jun (Ser63) II Antibody
3270 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb
8752 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (PE Conjugate)
9164 : Phospho-c-Jun (Ser73) Antibody
12714 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2303 : Phospho-c-Jun (Thr91) Antibody
2993 : Phospho-c-Jun (Thr93) Antibody
2994 : Phospho-c-Jun (Ser243) Antibody
  rat

 
T2 ______MTAKMETTF
T8 MTAKMETTFYDDALN
S37 NPKILKQSMTLNLAD
N48 NLADPVGNLKPHLRA
K50 ADPVGNLKPHLRAKN
K56 LKPHLRAKNSDLLts
S58 PHLRAKNSDLLtsPD
T62‑p AKNSDLLtsPDVGLL
S63‑p KNSDLLtsPDVGLLK
S73‑p VGLLKLAsPELERLI
S83 LERLIIQSSNGHITT
S84 ERLIIQSSNGHITTT
T89 QSSNGHITTTPTPTQ
T91 SNGHITTTPTPTQFL
T93 GHITTTPTPTQFLCP
T95 ITTTPTPTQFLCPKN
Y170 LHSEPPVYANLSNFN
K229 HPRLQALKEEPQTVP
T234 ALKEEPQTVPEMPGE
T242 VPEMPGETPPLsPID
S246‑p PGETPPLsPIDMESQ
S252 LsPIDMESQERIKAE
K257 MESQERIKAERKRMR
K271 RNRIAASKCRKRKLE
K274 IAASKCRKRKLERIA
K276 ASKCRKRKLERIARL
T289 RLEEKVKTLKAQNSE
K312 REQVAQLKQKVMNHV
2361 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb
2363 : Phospho-c-Jun (Ser63) (58A6) Mouse mAb
5464 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb (Biotinylated)
9261 : Phospho-c-Jun (Ser63) II Antibody
3270 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb
8752 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (PE Conjugate)
9164 : Phospho-c-Jun (Ser73) Antibody
12714 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2303 : Phospho-c-Jun (Thr91) Antibody
2993 : Phospho-c-Jun (Thr93) Antibody
2994 : Phospho-c-Jun (Ser243) Antibody
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