the protooncogene c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The Jun Kinases (JNKs) binds to the N-terminal region of c-Jun and phosphorylate it in response to extracellular signals including growth factors, cytokines and stress, regulating its transcriptional activity. Note: This description may include information from UniProtKB.
Molecular Function: DNA binding; enzyme binding; GTPase activator activity; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA binding; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: cellular response to hormone stimulus; negative regulation of DNA binding; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; regulation of cell cycle; regulation of cell proliferation; regulation of transcription factor activity; response to cAMP; response to cytokine stimulus; response to drug; response to lipopolysaccharide; response to mechanical stimulus; response to radiation; SMAD protein nuclear translocation; transforming growth factor beta receptor signaling pathway