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Protein Page:
CHOP (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CHOP a transcriptional-regulatory protein of the bZIP family. Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA. May play an important role in melanoma progression. CK2-mediated phosphorylation inhibits its transcriptional activity. Up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Autophagy; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12q13.1-q13.2
Cellular Component: cytosol; late endosome; nucleoplasm; nucleus
Molecular Function: cAMP response element binding protein binding; DNA binding; leucine zipper domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription corepressor activity; transcription factor activity; transcription factor binding
Biological Process: aging; blood vessel maturation; cell cycle arrest; cell redox homeostasis; cellular protein metabolic process; embryonic organ development; ER overload response; inhibition of CREB transcription factor; mRNA transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; negative regulation of myoblast differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of interleukin-8 production; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; regulation of transcription in response to stress; regulation of transcription, DNA-dependent; release of sequestered calcium ion into cytosol; response to amphetamine; response to DNA damage stimulus; response to drug; response to hydrogen peroxide; response to nutrient; response to starvation; response to unfolded protein; unfolded protein response; Wnt receptor signaling pathway
Disease: Myxoid Liposarcoma
Reference #:  P35638 (UniProtKB)
Alt. Names/Synonyms: C/EBP homologous protein; C/EBP zeta; C/EBP-homologous protein; C/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CEBPZ; CHOP; CHOP-10; CHOP10; DDIT-3; DDIT3; DNA damage-inducible transcript 3 protein; DNA-damage-inducible transcript 3; GADD153; Growth arrest and DNA damage-inducible protein GADD153; growth arrest- and DNA damage-inducible; MGC4154
Gene Symbols: DDIT3
Molecular weight: 19,175 Da
Basal Isoelectric point: 4.61  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CHOP

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S79‑p, S82‑p
transcription, inhibited: S14‑p, S15‑p, S30‑p, S31‑p
activity, inhibited: S14‑p, S15‑p, S30‑p, S31‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S14‑p PFSFGTLssWELEAW
1 0 S15‑p FSFGTLssWELEAWY
1 0 S30‑p EDLQEVLssDENGGT
1 0 S31‑p DLQEVLssDENGGTY
0 1 S49‑p PGNEEEEsKIFTtLD
0 1 T54‑p EEsKIFTtLDPASLA
0 1 T64‑p PASLAWLtEEEPEPA
1 1 S79‑p EVTSTSQsPHsPDSS
1 1 S82‑p STSQsPHsPDSSQSS
0 1 S108 RTRKRKQSGHSPARA
0 1 K121 RAGKQRMKEKEQENE
  mouse

 
S14 PFTLETVSSWELEAW
S15 FTLETVSSWELEAWY
S30 EDLQEVLSSDEIGGT
S31 DLQEVLSSDEIGGTY
S49 PGNEEEESKTFTTLD
T54 EESKTFTTLDPASLA
T64 PASLAWLTEEPGPTE
S78‑p EVTRTSQsPRsPDSS
S81‑p RTSQsPRsPDSSQSS
S107‑p RTRKRKQsGQCPARP
K120‑ub RPGKQRMkEKEQENE
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