a member of the MPI phosphatase family. Activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. Shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. At least four transcript variants for this gene exist. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis
Cellular Component: cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function: phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; WW domain binding
Biological Process: cell division; cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA replication; G2/M transition of mitotic cell cycle; mitosis; regulation of cell cycle; regulation of cyclin-dependent protein kinase activity; regulation of mitosis; spermatogenesis; viral reproduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.