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Protein Page:
C/EBP-beta (rat)

C/EBP-beta a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-alpha, -delta and -gamma. Involved in immune and inflammatory responses. Specifically binds to regulatory regions of genes encoding IL-6, other cytokines and several acute-phase proteins. There are two forms of C/EBPbeta, the 38kDa liver activating protein (LAP) and the 20kDa liver inhibitory protein (LIP) which may be products of alternative translation. LAP is a transcriptional activator while LIP may inhibit C/EBPbeta transcriptional activity. Phosphorylated and activated by ERK1/2. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Cellular Component: cytoplasm; nuclear chromatin; nuclear matrix; nucleoplasm; nucleus
Molecular Function: chromatin binding; DNA binding; glucocorticoid receptor binding; histone acetyltransferase binding; histone deacetylase binding; kinase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor binding
Biological Process: brown fat cell differentiation; defense response to bacterium; embryonic placenta development; fat cell differentiation; liver development; mammary gland epithelial cell proliferation; memory; negative regulation of neuron apoptosis; negative regulation of T cell proliferation; negative regulation of transcription, DNA-dependent; neuron differentiation; ovarian follicle development; positive regulation of fat cell differentiation; positive regulation of interleukin-4 production; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of interleukin-6 biosynthetic process; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; response to lipopolysaccharide
Reference #:  P21272 (UniProtKB)
Alt. Names/Synonyms: C/EBP beta; C/EBP-related protein 2; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; Cebpb; Crp2; IL-6DBP; Il6dbp; Interleukin-6-dependent-binding protein; LAP; Liver activating protein (LAP also NF-IL6 nuclear factor-IL6 previously designated TCF5); liver activating protein (LAP); Liver activating protein (LAP, also NF-IL6, nuclear factor-IL6, previously designated TCF5); Liver-enriched transcriptional activator; NF-IL6; nuclear factor-IL6; SF-B; Sfb; Silencer factor B; TCF5
Gene Symbols: Cebpb
Molecular weight: 31,503 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Growth And Differentiation Control by MAPKs  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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