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Protein Page:
C/EBP-alpha (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
C/EBP-alpha a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-beta and CEBP-gamma. Binds to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: nucleolus; nucleus
Molecular Function: DNA binding; kinase binding; protein binding; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: brown fat cell differentiation; cell maturation; cholesterol metabolic process; cytokine and chemokine mediated signaling pathway; embryonic placenta development; fat cell differentiation; generation of precursor metabolites and energy; glucose homeostasis; granulocyte differentiation; inner ear development; lipid homeostasis; liver development; lung development; macrophage differentiation; mitochondrion organization and biogenesis; myeloid cell differentiation; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of fat cell differentiation; positive regulation of osteoblast differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription, DNA-dependent; urea cycle; viral reproduction; white fat cell differentiation
Disease: Leukemia, Acute Myeloid
Reference #:  P49715 (UniProtKB)
Alt. Names/Synonyms: C/EBP alpha; C/EBP-alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer-binding protein alpha; CEBP; CEBPA
Gene Symbols: CEBPA
Molecular weight: 37,561 Da
Basal Isoelectric point: 7.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

C/EBP-alpha

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, altered: S21‑p
cell differentiation, inhibited: S21‑p
transcription, altered: S21‑p
transcription, inhibited: S21‑p
activity, induced: S21‑p
activity, inhibited: S21‑p
molecular association, regulation: S21‑p
protein conformation: S21‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
9 1 S21‑p PMSSHLQsPPHAPSS
0 2 K161‑ac ALRPLVIkQEPREED
0 1 K161‑ub ALRPLVIkQEPREED
2 0 K161 ALRPLVIKQEPREED
9 0 P197 SHPHPHPPPAHLAAP
7 0 T226 HLQPGHPTPPPTPVP
7 0 T230 GHPTPPPTPVPsPHP
4 0 S234‑p PPPTPVPsPHPAPAL
3 0 A252 GLPGPGSALKGLGAA
0 1 S266‑p AHPDLRAsGGSGAGK
0 1 K313‑ub RNVETQQkVLELTSD
0 1 S332‑p RKRVEQLsRELDTLR
2841 : Phospho-C/EBPalpha (Ser21) Antibody
2844 : Phospho-C/EBPalpha (Thr222/226) Antibody
2844 : Phospho-C/EBPalpha (Thr222/226) Antibody
  mouse

 
S21‑p PMSSHLQsPPHAPSN
K159 ALRPLVIKQEPREED
K159 ALRPLVIKQEPREED
K159‑sm ALRPLVIkQEPREED
S193‑p PPPHPHAsPAHLAAP
T222‑p HLQPGHPtPPPtPVP
T226‑p GHPtPPPtPVPsPHA
S230‑p PPPtPVPsPHAAPAL
A248 GLPGPGSALKGLAGA
G262 AHPDLRTGGGGGGSG
K314 RNVETQQKVLELTSD
S333 RKRVEQLSRELDTLR
2841 : Phospho-C/EBPalpha (Ser21) Antibody
2844 : Phospho-C/EBPalpha (Thr222/226) Antibody
2844 : Phospho-C/EBPalpha (Thr222/226) Antibody
  rat

 
S21‑p PMSSHLQsPPHAPSN
K159‑ac ALRPLVIkQEPREED
K159 ALRPLVIKQEPREED
K159‑sm ALRPLVIkQEPREED
S193‑p PPPHPHAsPAHLAAP
T222‑p HLQPGHPtPPPtPVP
T226‑p GHPtPPPtPVPsPHP
S230‑p PPPtPVPsPHPAPAM
S248‑p GLPGPGGsLKGLAGP
G262 PHPDLRTGGGGGGGA
K313 RNVETQQKVLELTSD
S332 RKRVEQLSRELDTLR
2841 : Phospho-C/EBPalpha (Ser21) Antibody
2844 : Phospho-C/EBPalpha (Thr222/226) Antibody
2844 : Phospho-C/EBPalpha (Thr222/226) Antibody
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