a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-beta and CEBP-gamma. Binds to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Note: This description may include information from UniProtKB.
Molecular Function: DNA binding; kinase binding; protein binding; protein homodimerization activity; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: fat cell differentiation; generation of precursor metabolites and energy; glucose homeostasis; granulocyte differentiation; lipid homeostasis; liver development; lung development; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription, DNA-dependent; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; transcription, DNA-dependent
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.