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Protein Page:
BRCA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BRCA1 the BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACC1 and preventing its dephosphorylation. Defects in BRCA1 are a cause of genetic susceptibility to breast cancer. Mutations in BRCA1 are thought to be responsible for more than 80% of inherited breast-ovarian cancer. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association may be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts (via BRCT domains) with CTIP. Associates with RNA polymerase II holoenzyme. Interacts with SMC1 and COBRA1. Interacts (via BRCT domains) with BRIP1. Interacts with FANCD2 (ubiquitinated). Interacts with BAP1. Interacts with Artemis and claspin. Interacts with H2AFX (phosphorylated on S140). Interacts with CHK1. Interacts with BRCC3. Five human isoforms are produced by alternative splicing and alternative initiation. Isoform 1 and isoform 3 are widely expressed. Isoform 1 is largely nuclear, while isoforms 3 and 5 are cytoplasmic. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Ubiquitin conjugating system; Transcription, coactivator/corepressor; Ubiquitin ligase; Nuclear receptor co-regulator; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: BRCA1-BARD1 complex; chromosome; cytoplasm; nucleoplasm; nucleus; plasma membrane; protein complex; ribonucleoprotein complex
Molecular Function: DNA binding; enzyme binding; protein binding; RNA binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: apoptosis; chordate embryonic development; chromosome segregation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA damage response, signal transduction resulting in induction of apoptosis; DNA double-strand break processing; DNA replication; DNA synthesis during DNA repair; dosage compensation, by inactivation of X chromosome; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; G2/M transition DNA damage checkpoint; negative regulation of estrogen receptor signaling pathway; negative regulation of fatty acid biosynthetic process; negative regulation of histone acetylation; negative regulation of histone H3-K9 methylation; negative regulation of transcription, DNA-dependent; positive regulation of angiogenesis; positive regulation of DNA repair; positive regulation of histone acetylation; positive regulation of histone H3-K4 methylation; positive regulation of protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; postreplication repair; protein autoubiquitination; protein sumoylation; protein ubiquitination; regulation of apoptosis; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase III promoter; response to DNA damage stimulus; response to estrogen stimulus; response to ionizing radiation; strand displacement
Disease: Breast Cancer; Breast-ovarian Cancer, Familial, Susceptibility To, 1; Pancreatic Cancer, Susceptibility To, 4
Reference #:  P38398 (UniProtKB)
Alt. Names/Synonyms: BRCA1; BRCA1/BRCA2-containing complex, subunit 1; BRCAI; BRCC1; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein; breast cancer 1, early onset; Breast cancer type 1 susceptibility protein; BROVCA1; IRIS; PSCP; RING finger protein 53; RNF53
Gene Symbols: BRCA1
Molecular weight: 207,721 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BRCA1

Protein Structure Not Found.
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Sites Implicated In
cell cycle regulation: S308‑p, S1387‑p, S1423‑p, S1457‑p, S1524‑p
DNA repair, altered: S1387‑p, S1423‑p, S1457‑p, S1524‑p
DNA repair, induced: S1164‑p
transcription, altered: S632‑p
transcription, induced: T509‑p
activity, induced: S988‑p
intracellular localization: T509‑p, S988‑p, S1143‑p, S1164‑p, S1189‑p, S1191‑p, S1280‑p, S1497‑p
molecular association, regulation: S1189‑p, S1423‑p, S1457‑p, S1497‑p, S1524‑p, S1542‑p
phosphorylation: S1423‑p, S1524‑p
protein stabilization: S694‑p, Y1552‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K50‑ac FCKFCMLkLLNQKKG
0 1 K109‑sm ANSYNFAkKENNsPE
0 12 S114‑p FAkKENNsPEHLkDE
1 0 K119‑sm NNsPEHLkDEVsIIQ
0 2 S123‑p EHLkDEVsIIQSMGY
0 1 T164‑p SNLGTVRtLRTKQRI
0 1 S184 SVYIELGSDSSEDTV
0 1 S186 YIELGSDSSEDTVNK
0 1 S187 IELGSDSSEDTVNKA
0 7 T208‑p DQELLQItPQGTRDE
0 2 S220‑p RDEISLDsAKKAACE
2 0 S308‑p KAEFCNKsKQPGLAR
0 5 S316 KQPGLARSQHNRWAG
0 1 K339‑sm RTPSTEKkVDLNADP
0 12 S395‑p RSDELLGsDDsHDGE
0 12 S398‑p ELLGsDDsHDGEsES
0 4 S403‑p DDsHDGEsESNAKVA
0 3 S423‑p LNEVDEYsGssEKID
0 1 S425‑p EVDEYsGssEKIDLL
0 2 S426‑p VDEYsGssEKIDLLA
0 4 S434‑p EKIDLLAsDPHEALI
0 1 K443‑sm PHEALICkSERVHSK
0 2 S451‑p SERVHSKsVEsNIED
0 2 S454‑p VHSKsVEsNIEDkIF
0 1 K459‑sm VEsNIEDkIFGKTYR
3 78 T509‑p LKRKRRPtsGLHPED
0 8 S510‑p KRKRRPtsGLHPEDF
0 2 G511 RKRRPtsGLHPEDFI
0 2 S551‑p QVMNITNsGHENKTK
0 1 K583‑sm KESAFKTkAEPISSS
0 36 S615‑p KNRLRRKsstRHIHA
0 36 S616‑p NRLRRKsstRHIHAL
0 5 T617‑p RLRRKsstRHIHALE
1 2 S632‑p LVVSRNLsPPNCTEL
0 1 S643 CTELQIDSCSSsEEI
0 1 S647‑p QIDSCSSsEEIKKKk
0 1 I650 SCSSsEEIKKKkYNQ
0 1 K654‑sm sEEIKKKkYNQMPVR
1 16 S694‑p QTSKRHDsDTFPELK
0 1 S708‑p KLTNAPGsFTKCSNT
0 1 K711 NAPGsFTKCSNTSEL
0 2 S713 PGsFTKCSNTSELKE
0 5 N714 GsFTKCSNTSELKEF
0 2 L718 KCSNTSELKEFVNPS
0 4 S725 LKEFVNPSLPREEKE
0 1 K734‑sm PREEKEEkLETVkVs
0 1 K739‑sm EEkLETVkVsNNAED
0 1 S741‑p kLETVkVsNNAEDPK
0 7 S753‑p DPKDLMLsGERVLQT
0 6 S803‑p TEPNKCVsQCAAFEN
0 3 S840 LGHEVNHSRETSIEM
0 2 S868‑p FKVSKRQsFAPFSNP
0 1 K918‑sm GKNESNIkPVQTVNI
0 1 G960 CLSSQFRGNETGLIt
0 6 T967‑p GNETGLItPNkHGLL
0 1 K970‑ub TGLItPNkHGLLQNP
0 1 Y978‑p HGLLQNPyRIPPLFP
6 0 S988‑p PPLFPIKsFVKTKCK
0 2 S1007‑p EENFEEHsMsPEREM
0 6 S1009‑p NFEEHsMsPEREMGN
0 1 S1050‑p NINEVGSsTNEVGSS
0 1 K1079‑sm LGRNRGPkLNAMLRL
0 1 S1101‑p YKQSLPGsNCKHPEI
0 1 K1104 SLPGsNCKHPEIKKQ
2 0 S1143‑p PMGSSHAsQVCSETP
1 1 S1164‑p GEIKEDTsFAENDIK
0 6 S1174 ENDIKESSAVFsKSV
0 1 S1178‑p KESSAVFsKSVQKGE
0 5 S1180 SSAVFsKSVQKGELs
0 13 S1187‑p SVQKGELsRsPsPFt
4 18 S1189‑p QKGELsRsPsPFtHT
2 13 S1191‑p GELsRsPsPFtHTHL
0 1 T1194‑p sRsPsPFtHTHLAQG
0 5 S1211‑p RGAKKLEssEENLss
0 4 S1212‑p GAKKLEssEENLssE
0 12 S1217‑p EssEENLssEDEELP
0 12 S1218‑p ssEENLssEDEELPC
0 1 N1235 HLLFGKVNNIPsQST
0 3 - gap
0 13 S1239‑p GKVNNIPsQSTRHsT
0 2 S1245‑p PsQSTRHsTVATECL
0 1 T1246 sQSTRHsTVATECLs
0 1 S1253‑p TVATECLsKNTEENL
0 1 S1266‑p NLLSLKNsLNDCsNQ
0 2 S1271‑p KNsLNDCsNQVILAK
2 4 S1280‑p QVILAKAsQEHHLsE
0 3 S1286‑p AsQEHHLsEETKCSA
0 6 S1328‑p SKQMRHQsEsQGVGL
0 4 S1330‑p QMRHQsEsQGVGLsD
0 18 S1336‑p EsQGVGLsDKELVsD
0 8 S1342‑p LsDKELVsDDEERGT
8 0 S1387‑p EDCSGLSsQSDILTT
13 2 S1423‑p AVLEQHGsQPSNSYP
5 3 S1457‑p SEKAVLTsQKsSEYP
0 5 S1460‑p AVLTsQKsSEYPIsQ
0 5 S1466‑p KsSEYPIsQNPEGLs
0 2 S1473‑p sQNPEGLsADKFEVs
0 1 S1480‑p sADKFEVsADsSTSK
0 1 S1483‑p KFEVsADsSTSKNKE
0 2 S1496‑p KEPGVERssPsKCPs
6 6 S1497‑p EPGVERssPsKCPsL
0 1 S1499‑p GVERssPsKCPsLDD
0 2 C1501 ERssPsKCPsLDDRW
0 1 S1503‑p ssPsKCPsLDDRWYM
0 1 Y1522 GSLQNRNYPsQEELI
9 15 S1524‑p LQNRNYPsQEELIKV
1 8 S1542‑p EEQQLEEsGPHDLtE
0 1 T1548‑p EsGPHDLtEtSyLPR
0 1 T1550‑p GPHDLtEtSyLPRQD
1 1 Y1552‑p HDLtEtSyLPRQDLE
1 0 S1572‑p ESGISLFsDDPEsDP
0 2 S1577‑p LFsDDPEsDPSEDRA
0 1 N1592 PESARVGNIPSSTSA
0 1 I1593 ESARVGNIPSSTSAL
0 1 S1598 GNIPSSTSALKVPQL
0 6 S1613‑p KVAESAQsPAAAHtT
0 1 T1619‑p QsPAAAHtTDTAGYN
0 1 S1642‑p EKPELTAsTERVNKR
0 1 E1660 VVSGLTPEEFMLVYk
0 1 K1667 EEFMLVYKFARKHHI
0 1 K1667‑ub EEFMLVYkFARKHHI
0 1 K1671 LVYkFARKHHITLTN
0 1 T1681‑p ITLTNLItEETTHVV
0 1 T1700‑p AEFVCERtLKYFLGI
0 1 T1720‑p VVSYFWVtQSIKERK
0 1 S1722 SYFWVtQSIKERKML
0 1 T1777‑p GPFTNMPtDQLEWMV
0 1 S1790‑p MVQLCGAsVVKELSS
9009 : Phospho-BRCA1 (Ser1524) Antibody
  BRCA1 iso6  
K50 FCKFCMLKLLNQKKG
K109 ANSYNFAKKENNSPE
S114 FAKKENNSPEHLKDE
K119 NNSPEHLKDEVSIIQ
S123 EHLKDEVSIIQSMGY
T164 SNLGTVRTLRTKQRI
S184 SVYIELGSDSSEDTV
S186 YIELGSDSSEDTVNK
S187 IELGSDSSEDTVNKA
T208 DQELLQITPQGTRDE
S220 RDEISLDSAKKAACE
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S284 EDCSGLSSQSDILTT
S320 AVLEQHGSQPSNSYP
S353 TSEKVLTSQKsSEYP
S356‑p KVLTSQKsSEYPIsQ
S362‑p KsSEYPIsQNPEGLs
S369‑p sQNPEGLsADKFEVS
S376 sADKFEVSADSSTSK
S379 KFEVSADSSTSKNKE
S392 KEPGVERSSPSKCPS
S393 EPGVERSSPSKCPSL
S395 GVERSSPSKCPSLDD
C397 ERSSPSKCPSLDDRW
S399 SSPSKCPSLDDRWYM
Y418 GSLQNRNYPSQEELI
S420 LQNRNYPSQEELIKV
S438 EEQQLEESGPHDLTE
T444 ESGPHDLTETSYLPR
T446 GPHDLTETSYLPRQD
Y448 HDLTETSYLPRQDLE
S468 ESGISLFSDDPESDP
S473 LFSDDPESDPSEDRA
N488 PESARVGNIPSSTSA
I489 ESARVGNIPSSTSAL
S494 GNIPSSTSALKVPQL
S509 KVAESAQSPAAAHTT
T515 QSPAAAHTTDTAGYN
S538 EKPELTASTERVNKR
E556 VVSGLTPEEFMLVYK
K563 EEFMLVYKFARKHHI
K563 EEFMLVYKFARKHHI
K567 LVYKFARKHHITLTN
T577 ITLTNLITEETTHVV
T596 AEFVCERTLKYFLGI
T616 VVSYFWVTQSIKERK
S618 SYFWVTQSIKERKML
T673 GPFTNMPTGCPPNCG
- gap
  BRCA1 iso7  
K50 FCKFCMLKLLNQKKG
K109 ANSYNFAKKENNSPE
S114 FAKKENNSPEHLKDE
K119 NNSPEHLKDEVSIIQ
S123 EHLKDEVSIIQSMGY
T164 SNLGTVRTLRTKQRI
S184 SVYIELGSDSSEDTV
S186 YIELGSDSSEDTVNK
S187 IELGSDSSEDTVNKA
T208 DQELLQITPQGTRDE
S220 RDEISLDSAKKAACE
S308 KAEFCNKSKQPGLAR
S316 KQPGLARSQHNRWAG
K339 RTPSTEKKVDLNADP
S395 RSDELLGSDDSHDGE
S398 ELLGSDDSHDGESES
S403 DDSHDGESESNAKVA
S423 LNEVDEYSGSSEKID
S425 EVDEYSGSSEKIDLL
S426 VDEYSGSSEKIDLLA
S434 EKIDLLASDPHEALI
K443 PHEALICKSERVHSK
S451 SERVHSKSVESNIED
S454 VHSKSVESNIEDKIF
K459 VESNIEDKIFGKTYR
T509 LKRKRRPTSGLHPED
S510 KRKRRPTSGLHPEDF
G511 RKRRPTSGLHPEDFI
S551 QVMNITNSGHENKTK
K583 KESAFKTKAEPISSS
S615 KNRLRRKSSTRHIHA
S616 NRLRRKSSTRHIHAL
T617 RLRRKSSTRHIHALE
S632 LVVSRNLSPPNCTEL
S643 CTELQIDSCSSSEEI
S647 QIDSCSSSEEIKKKK
I650 SCSSSEEIKKKKYNQ
K654 SEEIKKKKYNQMPVR
S694 QTSKRHDSDTFPELK
S708 KLTNAPGSFTKCSNT
K711 NAPGSFTKCSNTSEL
S713 PGSFTKCSNTSELKE
N714 GSFTKCSNTSELKEF
L718 KCSNTSELKEFVNPS
S725 LKEFVNPSLPREEKE
K734 PREEKEEKLETVKVS
K739 EEKLETVKVSNNAED
S741 KLETVKVSNNAEDPK
S753 DPKDLMLSGERVLQT
S803 TEPNKCVSQCAAFEN
S840 LGHEVNHSRETSIEM
S868 FKVSKRQSFAPFSNP
K918 GKNESNIKPVQTVNI
G960 CLSSQFRGNETGLIT
T967 GNETGLITPNKHGLL
K970 TGLITPNKHGLLQNP
Y978 HGLLQNPYRIPPLFP
S988 PPLFPIKSFVKTKCK
S1007 EENFEEHSMSPEREM
S1009 NFEEHSMSPEREMGN
S1050 NINEVGSSTNEVGSS
K1079 LGRNRGPKLNAMLRL
S1101 YKQSLPGSNCKHPEI
K1104 SLPGSNCKHPEIKKQ
S1143 PMGSSHASQVCSETP
S1164 GEIKEDTSFAENDIK
S1174 ENDIKESSAVFSKSV
S1178 KESSAVFSKSVQKGE
S1180 SSAVFSKSVQKGELS
S1187 SVQKGELSRSPSPFT
S1189 QKGELSRSPSPFTHT
S1191 GELSRSPSPFTHTHL
T1194 SRSPSPFTHTHLAQG
S1211 RGAKKLESSEENLSS
S1212 GAKKLESSEENLSSE
S1217 ESSEENLSSEDEELP
S1218 SSEENLSSEDEELPC
N1235 HLLFGKVNNIPSQST
- gap
S1239 GKVNNIPSQSTRHST
S1245 PSQSTRHSTVATECL
T1246 SQSTRHSTVATECLS
S1253 TVATECLSKNTEENL
S1266 NLLSLKNSLNDCSNQ
S1271 KNSLNDCSNQVILAK
S1280 QVILAKASQEHHLSE
S1286 ASQEHHLSEETKCSA
S1328 SKQMRHQSESQGVGL
S1330 QMRHQSESQGVGLSD
S1336 ESQGVGLSDKELVSD
S1342 LSDKELVSDDEERGT
S1387 EDCSGLSSQSDILTT
S1423 AVLEQHGSQPSNSYP
S1478 EHISVLTSQKSSEYP
S1481 SVLTSQKSSEYPISQ
S1487 KSSEYPISQNPEGLS
S1494 SQNPEGLSADKFEVS
S1501 SADKFEVSADSSTSK
S1504 KFEVSADSSTSKNKE
S1517 KEPGVERSSPSKCPS
S1518 EPGVERSSPSKCPSL
S1520 GVERSSPSKCPSLDD
C1522 ERSSPSKCPSLDDRW
S1524 SSPSKCPSLDDRWYM
Y1543 GSLQNRNYPSQEELI
S1545 LQNRNYPSQEELIKV
S1563 EEQQLEESGPHDLTE
T1569 ESGPHDLTETSYLPR
T1571 GPHDLTETSYLPRQD
Y1573 HDLTETSYLPRQDLE
S1593 ESGISLFSDDPESDP
S1598 LFSDDPESDPSEDRA
N1613 PESARVGNIPSSTSA
I1614 ESARVGNIPSSTSAL
S1619 GNIPSSTSALKVPQL
S1634 KVAESAQSPAAAHTT
T1640 QSPAAAHTTDTAGYN
S1663 EKPELTASTERVNKR
E1681 VVSGLTPEEFMLVYK
K1688 EEFMLVYKFARKHHI
K1688 EEFMLVYKFARKHHI
K1692 LVYKFARKHHITLTN
T1702 ITLTNLITEETTHVV
T1721 AEFVCERTLKYFLGI
T1741 VVSYFWVTQSIKERK
S1743 SYFWVTQSIKERKML
T1798 GPFTNMPTDQLEWMV
S1811 MVQLCGASVVKELSS
  mouse

 
K50 FCKFCMLKLLNQKKG
K109 TNGFSFSKKRNNsCE
S114‑p FSKKRNNsCERLNEE
N119 NNsCERLNEEASIIQ
S123 ERLNEEASIIQSVGY
S163 SNLGIVRSVKKNRQT
S183‑p SVYIELDsDssEETV
S185‑p YIELDsDssEETVTK
S186‑p IELDsDssEETVTKP
A207 DQELLQTAPQEAGDE
S219 GDEGKLHSAEEAACE
S305 KAEFCNKSKQPGIAV
S313‑p KQPGIAVsQQSRWAA
K336 QVPSTGEKVGPNADS
S392 RTGEMLTSDSASARR
S396 MLTSDSASARRHESN
H400 DSASARRHESNAEAA
S421 NEVDGGFSSSRKTDL
S422 EVDGGFSSSRKTDLV
S423 VDGGFSSSRKTDLVT
T430 SRKTDLVTPDPHHTL
K440 PHHTLMCKSGRDFSK
P448 SGRDFSKPVEDNISD
D451 DFSKPVEDNISDKIF
K456 VEDNISDKIFGKSYQ
S502‑p NKLKRKRstsLQPED
T503‑p KLKRKRstsLQPEDF
S504‑p LKRKRstsLQPEDFI
S544 EQAVSTTSNCQENKI
G577 KEPASTAGAKSISNS
S609 KNRLRRKSSIRCALP
S610 NRLRRKSSIRCALPL
I611 RLRRKSSIRCALPLE
S625‑p EPISRNPsPPTCAEL
S636‑p CAELQIDsCGSSEEt
S640 QIDsCGSSEEtKKNH
T643‑p sCGSSEEtKKNHSNQ
H647 SEEtKKNHSNQQPAG
S686‑p HIRKRRAsDAFPEEK
L700 KLMNKAGLLTsCssP
S703‑p NKAGLLTsCssPRKs
S705‑p AGLLTsCssPRKsQG
S706‑p GLLTsCssPRKsQGP
S710‑p sCssPRKsQGPVNPs
S717‑p sQGPVNPsPQRTGTE
Q725 PQRTGTEQLETRQMS
Q730 TEQLETRQMSDSAKE
S732 QLETRQMSDSAKELG
G744 ELGDRVLGGEPSGKT
T795 TGSAQCMTQFVASEN
S831‑p LRHALNLsQEKVEME
S858‑p FQVSKRQsFALFSKP
S903 GQEEFEISHVQAVAA
S943‑p CPSSHYRsGENGLSA
T951 GENGLSATGKSGISQ
K953 NGLSATGKSGISQNS
H961 SGISQNSHFKQSVSP
S971‑p QSVSPIRsSIKTDNR
T990 EGRFERHTSSTEMAV
S992 RFERHTSSTEMAVGN
- gap
K1048 LGRNRGPKVNTVPPL
S1070 CQQSVPVSDKYLEIK
K1072 QSVPVSDKYLEIKKQ
F1106 QSMSGKVFQVCSETP
S1127 VEIQGHTSFGEGDIM
S1137‑p EGDIMERsAVFNGsI
N1141 MERsAVFNGsILRRE
S1143‑p RsAVFNGsILRRESs
S1150‑p sILRRESsRsPsPVT
S1152‑p LRRESsRsPsPVTHA
S1154‑p RESsRsPsPVTHASK
T1157 sRsPsPVTHASKSQS
S1174 RASRKLESSEESDST
S1175 ASRKLESSEESDSTE
S1180 ESSEESDSTEDEDLP
T1181 SSEESDSTEDEDLPC
S1197‑p QHLLSRIsNtPELTR
T1199‑p LLSRIsNtPELTRCS
- gap
S1206 tPELTRCSsAVTQRM
S1207‑p PELTRCSsAVTQRMP
P1214 sAVTQRMPEKAEGTQ
S1227 TQAPWKGSSSDCNNE
N1232 KGSSSDCNNEVIMIE
S1241 EVIMIEASQEHQFSE
S1247 ASQEHQFSEDPRCSG
C1289 SKQRSHQCGNEEAFL
N1291 QRSHQCGNEEAFLsD
S1297‑p GNEEAFLsDKELISD
S1303 LsDKELISDNEEMAT
S1343 TNLSEDCSQSDILTT
N1379 AVLEQRGNQPSGHSP
S1413 SGAAILTSKNINENP
I1416 AILTSKNINENPVsQ
S1422‑p NINENPVsQNLKSAC
C1429 sQNLKSACDDKFQLQ
Q1436 CDDKFQLQHLEGPTS
G1440 FQLQHLEGPTSGDDE
P1453 DESGMGRPsPFKsPL
S1454‑p ESGMGRPsPFKsPLA
F1456 GMGRPsPFKsPLAGS
S1458‑p GRPsPFKsPLAGSRG
L1460 PsPFKsPLAGSRGSA
S1479‑p RHLQKRNsPSQEELL
S1481 LQKRNsPSQEELLQP
S1495 PAGSEASSEPHNSTG
T1501 SSEPHNSTGQSCLPR
S1504 PHNSTGQSCLPRREL
C1505 HNSTGQSCLPRRELE
S1525 GSGISLFSSRDPESE
R1527 GISLFSSRDPESESP
T1542‑p KEPAHIGttPASTsA
T1543‑p EPAHIGttPASTsAL
S1548‑p GttPASTsALKIPQG
S1561 QGQVAFRSAAAAGAD
A1567 RSAAAAGADKAVVGI
S1584 KIKPELTSSEERADR
K1603‑ac VVSGLTPkEVMTVQk
K1610‑ac kEVMTVQkFAEkYRL
K1610 kEVMTVQKFAEkYRL
K1614‑ac TVQkFAEkYRLTLTD
T1624 LTLTDAITEETTHVI
T1643 AEFVCERTLKYFLGI
V1663 IVSYSWVVRsIQERR
S1665‑p SYSWVVRsIQERRLL
K1719 EPFTNMPKDELERML
S1732 MLQLCGASVVKELPS
  rat

 
K50 FCKFCMLKLLNQKKG
K109 ANGFSFSKKKNSSSE
S114 FSKKKNSSSELLNED
N119 NSSSELLNEDASIIQ
S123 ELLNEDASIIQSVGY
S163 SNLGIVRSMKKNRQT
S183 SVYIALESDSSEERV
S185 YIALESDSSEERVNA
S186 IALESDSSEERVNAP
A207 DQELFQIAPGGAGDE
S219 GDEGKLNSAKKAACD
S306 KAEFCDRSKQSGAAV
S314 KQSGAAVSQQSRWAD
K337 PVPRTEGKADPNVDS
S393 RTGEMLTSDNASDRR
S397 MLTSDNASDRRPASN
P401 DNASDRRPASNAEAA
S422 NEVDGCFSSSKKIDL
S423 EVDGCFSSSKKIDLV
S424 VDGCFSSSKKIDLVA
A431 SKKIDLVAPDPDNAV
T441 PDNAVMCTSGRDFSK
P449 SGRDFSKPVENIIND
N452 DFSKPVENIINDKIF
K457 VENIINDKIFGKTYQ
S503 NKLKRKRSTCLHPED
T504 KLKRKRSTCLHPEDF
C505 LKRKRSTCLHPEDFI
S545 DQAMSITSNGQENRA
K578 KEPAFTAKAKSISNS
S610 KNRLRRKSTRCVLPL
T611 NRLRRKSTRCVLPLE
- gap
S625 EPISRNPSPPTCAEL
S636 CAELQIESCGSSEET
S640 QIESCGSSEETKKNN
T643 SCGSSEETKKNNSNQ
N647 SEETKKNNSNQTPAG
S686 HIRKRSASDAFPEEK
L700 KLMNKAGLLTSCSSP
S703 NKAGLLTSCSSPRKP
S705 AGLLTSCSSPRKPQG
S706 GLLTSCSSPRKPQGP
P710 SCSSPRKPQGPVNPs
S717‑p PQGPVNPsPERKGIE
Q725 PERKGIEQLEMCQMP
Q730 IEQLEMCQMPDNNKE
P732 QLEMCQMPDNNKELG
G744 ELGDLVLGGEPSGKP
T795 TGSVQCMTQFVASEN
N831 LRHELNHNQETIEME
S858 FQVSKRQSFALFSKL
S907 GQEESEISHVQAVTV
S947 CPSSHYRSCENGLNT
T955 CENGLNTTDKSGISQ
K957 NGLNTTDKSGISQNS
H965 SGISQNSHFRQSVSP
S975 QSVSPLRSSIKTDNR
T994 EGRFEKHTERGMGNE
- gap
- gap
K1049 LDRNRGPKVNTVSLL
S1071 SKQSAPVSDkYLEIK
K1073‑ac QSAPVSDkYLEIKQE
F1107 PMRSDKTFQVCSETP
S1128 VEIQENASFGEGGIT
S1138 EGGITEKSAIFNGSV
N1142 TEKSAIFNGSVLRRE
S1144 KSAIFNGSVLRRESS
S1151 SVLRRESSRSPSPVT
S1153 LRRESSRSPSPVTHA
S1155 RESSRSPSPVTHASK
T1158 SRSPSPVTHASKSRS
F1175 RGSRKLEFSEESDST
S1176 GSRKLEFSEESDSTE
S1181 EFSEESDSTEDEDLP
T1182 FSEESDSTEDEDLPC
S1198 QHLLSRVSSTPELTR
T1200 LLSRVSSTPELTRCS
- gap
S1207 TPELTRCSSVVTQRV
S1208 PELTRCSSVVTQRVP
P1215 SVVTQRVPEKAKGTQ
S1228 TQAPRKSSISDCNNE
N1233 KSSISDCNNEVILGE
S1242 EVILGEASQEYQFSE
S1248 ASQEYQFSEDAKCSG
A1290 SKQRRHQAENEEAFL
N1292 QRRHQAENEEAFLSD
S1298 ENEEAFLSDKELISD
S1304 LSDKELISDHEDMAA
S1344 ANLSEDCSQSDILTT
S1380 AVLEQHGSQPSGHPP
S1414 SGTAILTSKNINENP
I1417 AILTSKNINENPVSQ
S1423 NINENPVSQNPKRAC
C1430 SQNPKRACDDKSQPQ
P1438 DDKSQPQPPDGLPSG
G1441 SQPQPPDGLPSGDKE
P1454 KESGMRRPSPFKSPL
S1455 ESGMRRPSPFKSPLT
F1457 GMRRPSPFKSPLTSS
S1459 RRPSPFKSPLTSSRC
L1461 PSPFKSPLTSSRCSA
S1480 RSLQNRNSTSQEELL
S1482 LQNRNSTSQEELLQP
C1496 PAXLEKSCEPHNLTG
T1502 SCEPHNLTGRSCLPR
S1505 PHNLTGRSCLPRQDL
C1506 HNLTGRSCLPRQDLE
S1526 ESGIRLVSSRDPDSE
R1528 GIRLVSSRDPDSESP
T1543 KVSALVCTAPASTSA
A1544 VSALVCTAPASTSAL
S1549 CTAPASTSALKISQG
S1564 QVAGSCRSPAAGGAD
A1570 RSPAAGGADTAVVEI
S1587 KIKPEVTSPKERAER
K1606 VVSGLTPKEVMIVQK
K1613 KEVMIVQKFAEKYRL
K1613 KEVMIVQKFAEKYRL
K1617 IVQKFAEKYRLALTD
T1627 LALTDVITEETTHVI
T1646 AEFVCERTLKYFLGI
I1666 IVSYSWVIKSIQERK
S1668 SYSWVIKSIQERKLL
K1722 EPFTNMPKDELERML
S1735 MLQLCGASVVKELPL
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