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Protein Page:
NXF1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NXF1 Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5. Belongs to the NXF family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 11q12-q13
Cellular Component: cytosol; nuclear speck; nucleoplasm; nucleus
Molecular Function: nucleotide binding; protein binding; single-stranded RNA binding
Biological Process: gene expression; mRNA export from nucleus; poly(A)+ mRNA export from nucleus; viral reproduction
Reference #:  Q9UBU9 (UniProtKB)
Alt. Names/Synonyms: DKFZp667O0311; MEX67; mRNA export factor TAP; Nuclear RNA export factor 1; NXF1; TAP; tip associating protein; Tip-associated protein; Tip-associating protein
Gene Symbols: NXF1
Molecular weight: 70,182 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NXF1

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K6‑ub __MADEGkSYsEHDD
0 4 S9‑p ADEGkSYsEHDDERV
0 1 R21 ERVNFPQRKKKGRGP
0 15 Y33‑p RGPFRWKyGEGNRRS
0 8 R42 EGNRRSGRGGSGIRS
0 1 R42 EGNRRSGRGGSGIRS
0 2 R51 GSGIRSSRLEEDDGD
0 2 S62‑p DDGDVAMsDAQDGPR
0 1 Y72‑p QDGPRVRyNPyttRP
0 88 Y75‑p PRVRyNPyttRPNRr
0 3 T76‑p RVRyNPyttRPNRrG
0 1 T77‑p VRyNPyttRPNRrGD
0 1 R82‑m1 yttRPNRrGDTWHDR
0 4 T95‑p DRDRIHVtVRRDRAP
0 1 K117‑ub TSQDGTSkNWFkITI
0 1 K121‑ub GTSkNWFkITIPYGR
0 8 T148‑p SKCSVPFtPIEFHYE
0 4 K173‑ub ASTASALkAVNYKIL
0 4 S188‑p DRENRRIsIIINSSA
0 1 H198 INSSAPPHTILNELK
0 1 K230‑ub SQQALDLkGLRSDPD
0 1 S251‑p DVVLNRRsCMAATLR
0 1 S299‑p NLKILNLsGNELkSE
0 5 K304‑ub NLsGNELkSERELDK
0 1 T554‑p AFAMPAPtPsssPVP
0 3 S556‑p AMPAPtPsssPVPtL
0 2 S557‑p MPAPtPsssPVPtLs
0 2 S558‑p PAPtPsssPVPtLsP
0 1 T562‑p PsssPVPtLsPEQQE
0 1 S564‑p ssPVPtLsPEQQEML
  NXF1 iso2  
K6 __MADEGKSYSEHDD
S9 ADEGKSYSEHDDERV
R21 ERVNFPQRKKKGRGP
Y33 RGPFRWKYGEGNRRS
R42 EGNRRSGRGGSGIRS
R42 EGNRRSGRGGSGIRS
R51 GSGIRSSRLEEDDGD
S62 DDGDVAMSDAQDGPR
Y72 QDGPRVRYNPYTTRP
Y75 PRVRYNPYTTRPNRR
T76 RVRYNPYTTRPNRRG
T77 VRYNPYTTRPNRRGD
R82 YTTRPNRRGDTWHDR
T95 DRDRIHVTVRRDRAP
K117 TSQDGTSKNWFKITI
K121 GTSKNWFKITIPYGR
T148 SKCSVPFTPIEFHYE
K173 ASTASALKAVNYKIL
S188 DRENRRISIIINSSA
H198 INSSAPPHTILNELK
K230 SQQALDLKGLRSDPD
S251 DVVLNRRSCMAATLR
S299 NLKILNLSGNELKSE
K304 NLSGNELKSERELDK
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
K6 __MADEGKSYNEHDD
N9 ADEGKSYNEHDDRVS
R20 DRVSFPQRRKKGRGP
C32 RGPFRWKCGEGNRRS
R41‑m1 EGNRRSGrGGSGVQS
R41‑m2 EGNRRSGrGGSGVQS
R50‑m1 GSGVQSSrFEEDDGD
N61 DDGDVAMNDPQDGPR
Y71 QDGPRVRYNPyTNRP
Y74‑p PRVRYNPyTNRPNRR
T75 RVRYNPyTNRPNRRG
N76 VRYNPyTNRPNRRGD
R81 yTNRPNRRGDGWHDR
T94 DRDRIHITVRRDRAP
K116 TSQDGTTKNWFKITI
K120 GTTKNWFKITIPYGR
N147 SKCSVPFNPIEFHYE
K172 ATTASALKGVNHKIQ
S187‑p DRENRRIsIIINASA
Y197‑p INASAPPyTVQNELK
K229 NQQALDLKGLRSDPD
S250 DVVLNRRSCMAATLR
S298 NLKTLNLSGNELKTE
K303 NLSGNELKTERELDK
T553 AFAMSAPTPsssPVP
S555‑p AMSAPTPsssPVPTL
S556‑p MSAPTPsssPVPTLS
S557‑p SAPTPsssPVPTLSP
T561 PsssPVPTLSPEQQE
S563 ssPVPTLSPEQQEML
  rat

 
K6 __MADEGKSYNEHDD
N9 ADEGKSYNEHDDRVS
R20‑m1 DRVSFPQrRKKGRGP
C32 RGPFRWKCGVGNRRS
R41 VGNRRSGRGGSGIRS
R41 VGNRRSGRGGSGIRS
R50 GSGIRSSRFEEDDGD
N61 DDGDVAMNDPQDGPR
F71 QDGPRVRFNPYTTRP
Y74 PRVRFNPYTTRPNRR
T75 RVRFNPYTTRPNRRR
T76 VRFNPYTTRPNRRRD
R81 YTTRPNRRRDTWHDR
T94 DRDRIHVTVRRDRAP
K116 TSQDGTTKNWFKITI
K120 GTTKNWFKITIPYGK
N147 SKCSVPFNPIEFHYE
K172 ATTASALKAVNYKIQ
S187 DRENGRISIIINSSA
Y197 INSSAPPYIVQNELK
K229 SQQALDLKGLRSDPD
G250 DVVLNRRGCMAAALR
S298 NLKILNLSGNELKSE
K303 NLSGNELKSEWELDK
T553 AFAMPAPTPSSSPVP
S555 AMPAPTPSSSPVPTL
S556 MPAPTPSSSPVPTLS
S557 PAPTPSSSPVPTLSQ
T561 PSSSPVPTLSQEQQD
S563 SSPVPTLSQEQQDML
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