an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial
Molecular Function: BH3 domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding
Biological Process: apoptotic mitochondrial changes; cytokinesis; mitotic cell cycle checkpoint; negative regulation of apoptosis; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; release of cytochrome c from mitochondria; response to cytokine stimulus; suppression by virus of host apoptosis