Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. Homodimer. Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells. Belongs to the dihydropyrimidine dehydrogenase family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 18.104.22.168; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes