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Protein Page:
MPO (human)

Overview
MPO Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 1.11.2.2; Oxidoreductase
Chromosomal Location of Human Ortholog: 17q23.1
Cellular Component: azurophil granule; extracellular space; lysosome; nucleus; secretory granule
Molecular Function: chromatin binding; heparin binding; peroxidase activity
Biological Process: defense response; hydrogen peroxide catabolic process; negative regulation of apoptosis; response to oxidative stress
Disease: Alzheimer Disease; Myeloperoxidase Deficiency
Reference #:  P05164 (UniProtKB)
Alt. Names/Synonyms: 84 kDa myeloperoxidase; 89 kDa myeloperoxidase; MPO; Myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain; PERM
Gene Symbols: MPO
Molecular weight: 83,869 Da
Basal Isoelectric point: 9.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MPO

Protein Structure Not Found.
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