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Protein Page:
AR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AR a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: Xq12
Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; protein complex
Molecular Function: androgen binding; androgen receptor activity; ATPase binding; beta-catenin binding; chromatin binding; enzyme binding; ligand-dependent nuclear receptor activity; protein binding; receptor binding; transcription factor activity; transcription factor binding
Biological Process: activation of NF-kappaB transcription factor; androgen receptor signaling pathway; cell-cell signaling; intracellular receptor-mediated signaling pathway; negative regulation of cell proliferation; negative regulation of integrin biosynthetic process; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of integrin biosynthetic process; positive regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription, DNA-dependent; protein oligomerization; signal transduction; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transport
Disease: Androgen Insensitivity Syndrome; Androgen Insensitivity, Partial; Hypospadias 1, X-linked; Prostate Cancer; Spinal And Bulbar Muscular Atrophy, X-linked 1
Reference #:  P10275 (UniProtKB)
Alt. Names/Synonyms: AIS; ANDR; Androgen receptor; AR; DHTR; Dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; TFM
Gene Symbols: AR
Molecular weight: 99,188 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AR

Protein Structure Not Found.
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Sites Implicated In
apoptosis, inhibited: S215‑p, S792‑p
cell cycle regulation: Y535‑p
cell growth, altered: Y269‑p, T282‑p, S293‑p, Y365‑p
cell growth, induced: S83‑p, Y269‑p
chromatin organization, altered: S792‑p
transcription, altered: S83‑p, S96‑p, S215‑p, S258‑p, T282‑p, S293‑p, S310‑p, S426‑p, S516‑p, Y535‑p, S651‑p, S792‑p
transcription, induced: Y225‑p, Y269‑p, S310‑p, Y365‑p, S516‑p, S579‑p, T851‑p
transcription, inhibited: S310‑p, R407‑p
activity, induced: T282‑p, S293‑p
activity, inhibited: S215‑p
intracellular localization: S83‑p, S215‑p, Y269‑p, Y535‑p, S579‑p, S651‑p, S792‑p
molecular association, regulation: S83‑p, Y269‑p, T282‑p, S293‑p, S310‑p, R407‑p, S579‑p
protein conformation: R407‑p
protein degradation: S215‑p, S516‑p
protein stabilization: S83‑p, S215‑p, S310‑p, T851‑p
ubiquitination: S215‑p, S516‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
4 1 S16‑p RVYPRPPsKTYRGAF
9 1 S83‑p QQQQQETsPRQQQQQ
7 8 S96‑p QQQGEDGsPQAHRRG
8 0 S215‑p SGRAREAsGAPtSSK
0 1 T219‑p REAsGAPtSSKDNyL
1 1 Y225‑p PtSSKDNyLGGTSTI
0 1 S233‑p LGGTSTIsDNAKELC
0 1 S244‑p KELCKAVsVsMGLGV
0 1 S246‑p LCKAVsVsMGLGVEA
3 3 S258‑p VEALEHLsPGEQLRG
4 2 Y269‑p QLRGDCMyAPLLGVP
1 0 T282‑p VPPAVRPtPCAPLAE
1 0 S293‑p PLAECKGsLLDDSAG
0 1 L294 LAECKGsLLDDSAGK
0 1 Y309‑p STEDTAEysPFKGGY
10 4 S310‑p TEDTAEysPFKGGYT
0 1 Y348‑p LPSTLSLyKSGALDE
0 1 Y359‑p ALDEAAAyQSRDyyN
0 1 Y364‑p AAyQSRDyyNFPLAL
2 2 Y365‑p AyQSRDyyNFPLALA
4 0 K388‑sm PHPHARIkLENPLDy
0 1 Y395‑p kLENPLDyGSAWAAA
1 0 R407‑p AAAAAQCrYGDLASL
3 1 S426‑p AAGPGSGsPSAAASS
4 2 S516‑p VSRVPYPsPTCVkSE
4 0 K521‑sm YPsPTCVkSEMGPWM
2 1 Y535‑p MDSYSGPyGDMRLET
0 1 Y552‑p DHVLPIDyYFPPQKT
2 0 S579‑p YGALTCGsCKVFFKR
8 0 K631‑ac GMTLGARkLkkLGNL
1 0 K631‑me GMTLGARkLkkLGNL
7 0 K633‑ac TLGARkLkkLGNLKL
6 0 K634‑ac LGARkLkkLGNLKLQ
8 4 S651‑p GEASSTTsPTEETTQ
0 1 K721 VHVVKWAKALPGFRN
1 0 R761‑me SFTNVNSrMLYFAPD
5 0 S792‑p CVRMRHLsQEFGWLQ
0 1 K826‑ub VDGLKNQkFFDELRM
0 1 K837‑ac ELRMNYIkELDRIIA
1 0 K846‑ub LDRIIACkRkNPtSC
1 0 K848‑ub RIIACkRkNPtSCSR
1 1 T851‑p ACkRkNPtSCSRRFy
0 1 Y858‑p tSCSRRFyQLTKLLD
0 1 Y916‑p SGKVKPIyFHTQ___
  AR iso3  
S16 RVYPRPPSKTYRGAF
S83 QQQQQETSPRQQQQQ
S96 QQQGEDGSPQAHRRG
S215 SGRAREASGAPTSSK
T219 REASGAPTSSKDNYL
Y225 PTSSKDNYLGGTSTI
S233 LGGTSTISDNAKELC
S244 KELCKAVSVSMGLGV
S246 LCKAVSVSMGLGVEA
S258 VEALEHLSPGEQLRG
Y269 QLRGDCMYAPLLGVP
T282 VPPAVRPTPCAPLAE
S293 PLAECKGSLLDDSAG
L294 LAECKGSLLDDSAGK
Y309 STEDTAEYSPFKGGY
S310 TEDTAEYSPFKGGYT
Y348 LPSTLSLYKSGALDE
Y359 ALDEAAAYQSRDYYN
Y364 AAYQSRDYYNFPLAL
Y365 AYQSRDYYNFPLALA
K388 PHPHARIKLENPLDY
Y395 KLENPLDYGSAWAAA
R407 AAAAAQCRYGDLASL
S426 AAGPGSGSPSAAASS
S516 VSRVPYPSPTCVKSE
K521 YPSPTCVKSEMGPWM
Y535 MDSYSGPYGDMRLET
Y552 DHVLPIDYYFPPQKT
S579 YGALTCGSCKVFFKR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
S16 RVYPRPPSKTYRGAF
S61 LQQRQETSPRRRRRQ
S75 QQHTEDGSPQAHIRG
T208 SARAREATGAPSSSK
S212 REATGAPSSSKDSYL
Y218 PSSSKDSYLGGNSTI
S226 LGGNSTISDSAKELC
S237 KELCKAVSVSMGLGV
S239 LCKAVSVSMGLGVEA
S251 VEALEHLSPGEQLRG
Y262 QLRGDCMYASLLGGP
T275 GPPAVRPTPCAPLPE
L286 PLPECKGLPLDEGPG
P287 LPECKGLPLDEGPGK
Y302 STEETAEYSSFKGGY
S303 TEETAEYSSFKGGYA
Y341 IPSSLSLYKSGALDE
Y352 ALDEAAAYQNRDYYN
Y357 AAYQNRDYYNFPLAL
Y358 AYQNRDYYNFPLALS
K381 THPHARIKLENPLDY
Y388 KLENPLDYGSAWAAA
R400 AAAAAQCRYGDLGSL
S419 VAGPSTGSPPATTSS
S495 VNRVPYPSPNCVKSE
K500 YPSPNCVKSEMGPWM
Y514 MENYSGPYGDMRLDS
Y531 DHVLPIDYYFPPQKT
S558 YGALTCGSCKVFFKR
K610 GMTLGARKLKKLGNL
K610 GMTLGARKLKKLGNL
K612 TLGARKLKKLGNLKL
K613 LGARKLKKLGNLKLQ
S630‑p GENSNAGsPTEDPSQ
K700‑ub VHVVKWAkALPGFRN
R740 SFTNVNSRMLYFAPD
S771 CVRMRHLSQEFGWLQ
K805 VDGLKNQKFFDELRM
K816 ELRMNYIKELDRIIA
K825 LDRIIACKRKNPTSC
K827 RIIACKRKNPTSCSR
T830 ACKRKNPTSCSRRFY
Y837 TSCSRRFYQLTKLLD
Y895 SGKVKPIYFHTQ___
  rat

 
S16 RVYPRPPSKTYRGAF
S61 LQQRQETSPRRRRRQ
S75‑p QQHPEDGsPQAHIRG
T211 SVRAREATGAPSSSK
S215 REATGAPSSSKDSYL
Y221 PSSSKDSYLGGNSTI
S229 LGGNSTISDSAKELC
S240 KELCKAVSVSMGLGV
S242 LCKAVSVSMGLGVEA
S254 VEALEHLSPGEQLRG
Y265 QLRGDCMYASLLGGP
T278 GPPAVRPTPCAPLAE
L289 PLAECKGLsLDEGPG
S290‑p LAECKGLsLDEGPGK
Y305 GTEETAEYSSFKGGY
S306 TEETAEYSSFKGGYA
Y344 IPSSLSLYKSGAVDE
Y355 AVDEAAAYQNRDYYN
Y360 AAYQNRDYYNFPLAL
Y361 AYQNRDYYNFPLALS
K384 THPHARIKLENPSDY
Y391 KLENPSDYGSAWAAA
R403 AAAAAQCRYGDLASL
S422 VAGPSTGSPPATASS
S498 VNRVPYPSPSCVKSE
K503 YPSPSCVKSEMGPWM
Y517 MENYSGPYGDMRLDS
Y534 DHVLPIDYYFPPQKT
S561 YGALTCGSCKVFFKR
K613 GMTLGARKLKKLGNL
K613 GMTLGARKLKKLGNL
K615 TLGARKLKKLGNLKL
K616 LGARKLKKLGNLKLQ
S633‑p GENSSAGsPTEDPSQ
K703 VHVVKWAKALPGFRN
R743 SFTNVNSRMLYFAPD
S774 CVRMRHLSQEFGWLQ
K808 VDGLKNQKFFDELRM
K819 ELRMNYIKELDRIIA
K828 LDRIIACKRKNPTSC
K830 RIIACKRKNPTSCSR
T833 ACKRKNPTSCSRRFY
Y840 TSCSRRFYQLTKLLD
Y898 SGKVKPIYFHTQ___
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