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Protein Page:
APP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
APP a cell surface receptor that influences neurite growth, neuronal adhesion and axonogenesis. Cleaved by secretases to form a number of peptides, some of which bind to the acetyltransferase complex Fe65/TIP60 to promote transcriptional activation. The Abeta peptide is released from the cell, its extracellular deposition and accumulation form the main components of amyloid plaques in Alzheimer's disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis. Can promote transcription activation through binding to Fe65-Tip60 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(O) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a RAGE-dependent pathway that activates p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, JIP1, SHC1 and, NUMB and DAB1. Binding to DAB1 inhibits its serine phosphorylation. Associates with microtubules in the presence of ATP and in a kinesin-dependent manner. Amyloid beta-42 binds nAChRA7 in hippocampal neurons. Beta-amyloid associates with HADH2. Soluble APP binds, via its N-terminal head, to FBLN1. Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex- opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra- striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. 10 isoforms of the human protein are produced by alternative splicing. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non- neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Belongs to the APP family. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Cell surface; Membrane protein, integral; Receptor, misc.; Apoptosis
Chromosomal Location of Human Ortholog: 21q21.3
Cellular Component: axon; cell surface; cytoplasm; cytosol; dendritic shaft; dendritic spine; endosome; extracellular region; extracellular space; Golgi apparatus; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; lipid raft; nuclear envelope lumen; perinuclear region of cytoplasm; plasma membrane; receptor complex; synapse; trans-Golgi network membrane
Molecular Function: DNA binding; enzyme binding; identical protein binding; protein binding; PTB domain binding; receptor binding; serine-type endopeptidase inhibitor activity
Biological Process: adult locomotory behavior; axon cargo transport; axon midline choice point recognition; axonogenesis; cellular copper ion homeostasis; cellular process; cellular protein metabolic process; collateral sprouting in the absence of injury; dendrite development; endocytosis; extracellular matrix organization and biogenesis; innate immune response; ionotropic glutamate receptor signaling pathway; locomotory behavior; mating behavior; mRNA polyadenylation; neurite development; neuron apoptosis; neuron remodeling; platelet degranulation; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; regulation of epidermal growth factor receptor activity; regulation of multicellular organism growth; regulation of synapse structure and activity; regulation of translation; visual learning
Disease: Alzheimer Disease
Reference #:  P05067 (UniProtKB)
Alt. Names/Synonyms: A4; AAA; ABETA; ABPP; AD1; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alzheimer disease amyloid protein; amyloid beta (A4) precursor protein; Amyloid beta A4 protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; APP; APPI; beta-amyloid peptide; Beta-amyloid protein 40; Beta-amyloid protein 42; Beta-APP40; Beta-APP42; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTFgamma; CVAP; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; P3(40); P3(42); peptidase nexin-II; PN-II; PN2; PreA4; Protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta
Gene Symbols: APP
Molecular weight: 86,943 Da
Basal Isoelectric point: 4.73  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APP

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
cell cycle regulation: T743‑p
cell growth, altered: T743‑p
intracellular localization: T743‑p
molecular association, regulation: T743‑p, Y757‑p
protein conformation: S697‑p
protein stabilization: T743‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T107 RGRKQCKTHPHFVIP
0 1 T107‑ga RGRKQCKtHPHFVIP
0 1 P109 RKQCKtHPHFVIPyR
0 2 Y115‑p HPHFVIPyRCLVGEF
1 1 S198 EESDNVDSADAEEDD
1 1 S206 ADAEEDDSDVWWGGA
0 1 T352‑ga MSQSLLKttQEPLAR
0 1 T353‑ga SQSLLKttQEPLARD
1 1 T366‑ga RDPVKLPttAAstPD
1 1 T367 DPVKLPtTAAstPDA
0 1 T367 DPVKLPtTAAstPDA
0 1 T367‑ga DPVKLPttAAstPDA
0 1 S370 KLPttAAStPDAVDK
0 1 S370‑ga KLPttAAstPDAVDK
0 1 T371‑ga LPttAAstPDAVDKY
0 1 Y378 tPDAVDKYLEtPGDE
0 1 T381‑p AVDKYLEtPGDENEH
0 1 T381‑ga AVDKYLEtPGDENEH
0 1 K395 HAHFQKAKERLEAKH
0 8 S441‑p HFQEKVEsLEQEAAN
0 1 T600‑ga LMPSLTEtKTTVELL
1 1 T651‑ga PAADRGLttRPGsGL
0 1 T652‑ga AADRGLttRPGsGLt
0 1 S656‑ga GLttRPGsGLtNIKt
0 1 T659‑ga tRPGsGLtNIKtEEI
1 0 K662 GsGLtNIKtEEIsEV
0 1 T663‑ga sGLtNIKtEEIsEVk
0 1 S667‑ga NIKtEEIsEVkMDAE
2 0 K670‑sm tEEIsEVkMDAEFRH
5 0 S679‑p DAEFRHDsGYEVHHQ
1 0 K687‑ne GYEVHHQkLVFFAED
1 0 S697‑p FFAEDVGsNkGAIIG
1 0 K699‑ne AEDVGsNkGAIIGLM
0 1 K724‑ac VITLVMLkkkQytsI
1 0 K724‑ne VITLVMLkkkQytsI
1 0 K724 VITLVMLKkkQytsI
0 2 K725‑ac ITLVMLkkkQytsIH
1 0 K725‑ne ITLVMLkkkQytsIH
1 0 K725 ITLVMLkKkQytsIH
1 1 K726 TLVMLkkKQytsIHH
1 0 K726‑ne TLVMLkkkQytsIHH
1 1 Y728‑p VMLkkkQytsIHHGV
4 0 T729‑p MLkkkQytsIHHGVV
5 0 S730‑p LkkkQytsIHHGVVE
34 7 T743‑p VEVDAAVtPEERHLS
1 42 K751‑ub PEERHLSkMQQNGyE
1 0 K751‑ne PEERHLSkMQQNGyE
11 863 Y757‑p SkMQQNGyENPtykF
0 2 T761‑p QNGyENPtykFFEQM
4 243 Y762‑p NGyENPtykFFEQMQ
1 4 K763‑ub GyENPtykFFEQMQN
1 0 K763‑ne GyENPtykFFEQMQN
3823 : Phospho-APP (Thr668) Antibody
6986 : Phospho-APP (Thr668) (D90B8) Rabbit mAb
  APP iso4  
T107 RGRKQCKTHPHFVIP
T107 RGRKQCKTHPHFVIP
P109 RKQCKTHPHFVIPYR
Y115 HPHFVIPYRCLVGEF
S198‑p EESDNVDsADAEEDD
S206‑p ADAEEDDsDVWWGGA
- gap
- gap
T291‑ga EEVVRVPttAAsTPD
T292‑p EVVRVPttAAsTPDA
T292 EVVRVPtTAAsTPDA
T292 EVVRVPtTAAsTPDA
S295‑p RVPttAAsTPDAVDK
S295 RVPttAASTPDAVDK
T296 VPttAAsTPDAVDKy
Y303‑p TPDAVDKyLETPGDE
T306 AVDKyLETPGDENEH
T306 AVDKyLETPGDENEH
K320 HAHFQKAKERLEAKH
S366 HFQEKVESLEQEAAN
T525 LMPSLTETKTTVELL
T576‑ga PAADRGLtTRPGSGL
T577 AADRGLtTRPGSGLT
S581 GLtTRPGSGLTNIkT
T584 TRPGSGLTNIkTEEI
K587‑sm GSGLTNIkTEEISEV
T588 SGLTNIkTEEISEVk
S592 NIkTEEISEVkMDAE
K595‑sm TEEISEVkMDAEFRH
S604 DAEFRHDSGYEVHHQ
K612 GYEVHHQKLVFFAED
S622 FFAEDVGSNKGAIIG
K624 AEDVGSNKGAIIGLM
K649 VITLVMLKKKQYtsI
K649 VITLVMLKKKQYtsI
K649 VITLVMLKKKQYtsI
K650 ITLVMLKKKQYtsIH
K650 ITLVMLKKKQYtsIH
K650 ITLVMLKKKQYtsIH
K651 TLVMLKKKQYtsIHH
K651 TLVMLKKKQYtsIHH
Y653 VMLKKKQYtsIHHGV
T654‑p MLKKKQYtsIHHGVV
S655‑p LKKKQYtsIHHGVVE
T668‑p VEVDAAVtPEERHLS
K676 PEERHLSKMQQNGyE
K676 PEERHLSKMQQNGyE
Y682‑p SKMQQNGyENPTyKF
T686 QNGyENPTyKFFEQM
Y687‑p NGyENPTyKFFEQMQ
K688 GyENPTyKFFEQMQN
K688 GyENPTyKFFEQMQN
  APP iso8  
T107 RGRKQCKTHPHFVIP
T107 RGRKQCKTHPHFVIP
P109 RKQCKTHPHFVIPYR
Y115 HPHFVIPYRCLVGEF
S198 EESDNVDSADAEEDD
S206 ADAEEDDSDVWWGGA
- gap
- gap
T347 VCGSAIPTTAASTPD
T348 CGSAIPTTAASTPDA
T348 CGSAIPTTAASTPDA
T348 CGSAIPTTAASTPDA
S351 AIPTTAASTPDAVDK
S351 AIPTTAASTPDAVDK
T352 IPTTAASTPDAVDKY
Y359 TPDAVDKYLETPGDE
T362 AVDKYLETPGDENEH
T362 AVDKYLETPGDENEH
K376 HAHFQKAKERLEAKH
S422 HFQEKVESLEQEAAN
T581 LMPSLTETKTTVELL
T632 PAADRGLTTRPGSGL
T633 AADRGLTTRPGSGLT
S637 GLTTRPGSGLTNIKT
T640 TRPGSGLTNIKTEEI
K643 GSGLTNIKTEEISEV
T644 SGLTNIKTEEISEVK
S648 NIKTEEISEVKMDAE
K651 TEEISEVKMDAEFRH
S660 DAEFRHDSGYEVHHQ
K668 GYEVHHQKLVFFAED
S678 FFAEDVGSNKGAIIG
K680 AEDVGSNKGAIIGLM
K705 VITLVMLKKKQYtsI
K705 VITLVMLKKKQYtsI
K705 VITLVMLKKKQYtsI
K706 ITLVMLKKKQYtsIH
K706 ITLVMLKKKQYtsIH
K706 ITLVMLKKKQYtsIH
K707 TLVMLKKKQYtsIHH
K707 TLVMLKKKQYtsIHH
Y709 VMLKKKQYtsIHHGV
T710‑p MLKKKQYtsIHHGVV
S711‑p LKKKQYtsIHHGVVE
T724‑p VEVDAAVtPEERHLS
K732 PEERHLSKMQQNGyE
K732 PEERHLSKMQQNGyE
Y738‑p SKMQQNGyENPTyKF
T742 QNGyENPTyKFFEQM
Y743‑p NGyENPTyKFFEQMQ
K744 GyENPTyKFFEQMQN
K744 GyENPTyKFFEQMQN
3823 : Phospho-APP (Thr668) Antibody
6986 : Phospho-APP (Thr668) (D90B8) Rabbit mAb
  APP iso10  
T51 RGRKQCKTHPHFVIP
T51 RGRKQCKTHPHFVIP
P53 RKQCKTHPHFVIPYR
Y59 HPHFVIPYRCLVGEF
S142 EESDNVDSADAEEDD
S150 ADAEEDDSDVWWGGA
- gap
- gap
T235 EEVVRVPTTAASTPD
T236 EVVRVPTTAASTPDA
T236 EVVRVPTTAASTPDA
T236 EVVRVPTTAASTPDA
S239 RVPTTAASTPDAVDK
S239 RVPTTAASTPDAVDK
T240 VPTTAASTPDAVDKY
Y247 TPDAVDKYLETPGDE
T250 AVDKYLETPGDENEH
T250 AVDKYLETPGDENEH
K264 HAHFQKAKERLEAKH
S310 HFQEKVESLEQEAAN
T469 LMPSLTETKTTVELL
T520 PAADRGLTTRPGSGL
T521 AADRGLTTRPGSGLT
S525 GLTTRPGSGLTNIKT
T528 TRPGSGLTNIKTEEI
K531 GSGLTNIKTEEISEV
T532 SGLTNIKTEEISEVK
S536 NIKTEEISEVKMDAE
K539 TEEISEVKMDAEFRH
S548 DAEFRHDSGYEVHHQ
K556 GYEVHHQKLVFFAED
S566 FFAEDVGSNKGAIIG
K568 AEDVGSNKGAIIGLM
K593 VITLVMLKKKQYTSI
K593 VITLVMLKKKQYTSI
K593 VITLVMLKKKQYTSI
K594 ITLVMLKKKQYTSIH
K594 ITLVMLKKKQYTSIH
K594 ITLVMLKKKQYTSIH
K595 TLVMLKKKQYTSIHH
K595 TLVMLKKKQYTSIHH
Y597 VMLKKKQYTSIHHGV
T598 MLKKKQYTSIHHGVV
S599 LKKKQYTSIHHGVVE
T612 VEVDAAVTPEERHLS
K620 PEERHLSKMQQNGYE
K620 PEERHLSKMQQNGYE
Y626 SKMQQNGYENPTYKF
T630 QNGYENPTYKFFEQM
Y631 NGYENPTYKFFEQMQ
K632 GYENPTYKFFEQMQN
K632 GYENPTYKFFEQMQN
  mouse

► Hide Isoforms
 
T107‑p RGRKQCKtHtHIVIP
T107 RGRKQCKTHtHIVIP
T109‑p RKQCKtHtHIVIPyR
Y115‑p HtHIVIPyRCLVGEF
S198 EESDSVDSADAEEDD
S206 ADAEEDDSDVWWGGA
T352 STQSLLKTTSEPLPQ
T353 TQSLLKTTSEPLPQD
T366 QDPDKLPTTAASTPD
T367 DPDKLPTTAASTPDA
T367 DPDKLPTTAASTPDA
T367 DPDKLPTTAASTPDA
S370 KLPTTAASTPDAVDK
S370 KLPTTAASTPDAVDK
T371 LPTTAASTPDAVDKY
Y378 TPDAVDKYLETPGDE
T381 AVDKYLETPGDENEH
T381 AVDKYLETPGDENEH
K395 HAHFQKAKERLEAKH
S441‑p HFQEKVEsLEQEAAN
T600 LMPSLTETKTTVELL
T651 PAADRGLTTRPGSGL
T652 AADRGLTTRPGSGLT
S656 GLTTRPGSGLTNIKT
T659 TRPGSGLTNIKTEEI
K662 GSGLTNIKTEEISEV
T663 SGLTNIKTEEISEVK
S667 NIKTEEISEVKMDAE
K670 TEEISEVKMDAEFGH
S679‑p DAEFGHDsGFEVRHQ
K687 GFEVRHQKLVFFAED
S697‑p FFAEDVGsNKGAIIG
K699 AEDVGsNKGAIIGLM
K724 VITLVMLKKkQYTSI
K724 VITLVMLKKkQYTSI
K724 VITLVMLKKkQYTSI
K725 ITLVMLKKkQYTSIH
K725 ITLVMLKKkQYTSIH
K725 ITLVMLKKkQYTSIH
K726‑ub TLVMLKKkQYTSIHH
K726 TLVMLKKKQYTSIHH
Y728 VMLKKkQYTSIHHGV
T729 MLKKkQYTSIHHGVV
S730 LKKkQYTSIHHGVVE
T743‑p VEVDAAVtPEERHLS
K751‑ub PEERHLSkMQQNGyE
K751 PEERHLSKMQQNGyE
Y757‑p SkMQQNGyENPTykF
T761 QNGyENPTykFFEQM
Y762‑p NGyENPTykFFEQMQ
K763‑ub GyENPTykFFEQMQN
K763 GyENPTyKFFEQMQN
3823 : Phospho-APP (Thr668) Antibody
6986 : Phospho-APP (Thr668) (D90B8) Rabbit mAb
  APP iso2  
T107 RGRKQCKTHTHIVIP
T107 RGRKQCKTHTHIVIP
T109 RKQCKTHTHIVIPYR
Y115 HTHIVIPYRCLVGEF
S198 EESDSVDSADAEEDD
S206 ADAEEDDSDVWWGGA
- gap
- gap
T291 EEVVRVPTtAASTPD
T292 EVVRVPTTAASTPDA
T292‑gl EVVRVPTtAASTPDA
T292 EVVRVPTTAASTPDA
S295 RVPTtAASTPDAVDK
S295 RVPTtAASTPDAVDK
T296 VPTtAASTPDAVDKY
Y303 TPDAVDKYLETPGDE
T306 AVDKYLETPGDENEH
T306 AVDKYLETPGDENEH
K320 HAHFQKAKERLEAKH
S366 HFQEKVESLEQEAAN
T525 LMPSLTETKTTVELL
T576 PAADRGLTTRPGSGL
T577 AADRGLTTRPGSGLT
S581 GLTTRPGSGLTNIKT
T584 TRPGSGLTNIKTEEI
K587 GSGLTNIKTEEISEV
T588 SGLTNIKTEEISEVK
S592 NIKTEEISEVKMDAE
K595 TEEISEVKMDAEFGH
S604 DAEFGHDSGFEVRHQ
K612 GFEVRHQKLVFFAED
S622 FFAEDVGSNKGAIIG
K624 AEDVGSNKGAIIGLM
K649 VITLVMLKkkQyTSI
K649 VITLVMLKkkQyTSI
K649‑ub VITLVMLkkkQyTSI
K650 ITLVMLkKkQyTSIH
K650 ITLVMLkKkQyTSIH
K650‑ub ITLVMLkkkQyTSIH
K651‑ub TLVMLkkkQyTSIHH
K651 TLVMLkkKQyTSIHH
Y653‑p VMLkkkQyTSIHHGV
T654 MLkkkQyTSIHHGVV
S655 LkkkQyTSIHHGVVE
T668‑p VEVDAAVtPEERHLS
K676‑ub PEERHLSkMQQNGyE
K676 PEERHLSKMQQNGyE
Y682‑p SkMQQNGyENPTykF
T686 QNGyENPTykFFEQM
Y687‑p NGyENPTykFFEQMQ
K688‑ub GyENPTykFFEQMQN
K688 GyENPTyKFFEQMQN
3823 : Phospho-APP (Thr668) Antibody
6986 : Phospho-APP (Thr668) (D90B8) Rabbit mAb
  rat

► Hide Isoforms
 
T107 RGRKQCKTHTHIVIP
T107 RGRKQCKTHTHIVIP
T109 RKQCKTHTHIVIPYR
Y115 HTHIVIPYRCLVGEF
S198 EESDSIDSADAEEDD
S206 ADAEEDDSDVWWGGA
T352 SSQSLLKTTSEPLPQ
T353 SQSLLKTTSEPLPQD
T366 QDPVKLPTTAASTPD
T367 DPVKLPTTAASTPDA
T367 DPVKLPTTAASTPDA
T367 DPVKLPTTAASTPDA
S370 KLPTTAASTPDAVDK
S370 KLPTTAASTPDAVDK
T371 LPTTAASTPDAVDKY
Y378 TPDAVDKYLETPGDE
T381 AVDKYLETPGDENEH
T381 AVDKYLETPGDENEH
K395‑ac HAHFQKAkERLEAKH
S441‑p HFQEKVEsLEQEAAN
T600 LMPSLTETKTTVELL
T651 PAADRGLTTRPGSGL
T652 AADRGLTTRPGSGLT
S656 GLTTRPGSGLTNIKT
T659 TRPGSGLTNIKTEEI
K662 GSGLTNIKTEEISEV
T663 SGLTNIKTEEISEVK
S667 NIKTEEISEVKMDAE
K670 TEEISEVKMDAEFGH
S679 DAEFGHDSGFEVRHQ
K687 GFEVRHQKLVFFAED
S697 FFAEDVGSNKGAIIG
K699 AEDVGSNKGAIIGLM
K724 VITLVMLKKKQYtsI
K724 VITLVMLKKKQYtsI
K724 VITLVMLKKKQYtsI
K725 ITLVMLKKKQYtsIH
K725 ITLVMLKKKQYtsIH
K725 ITLVMLKKKQYtsIH
K726 TLVMLKKKQYtsIHH
K726 TLVMLKKKQYtsIHH
Y728 VMLKKKQYtsIHHGV
T729‑p MLKKKQYtsIHHGVV
S730‑p LKKKQYtsIHHGVVE
T743‑p VEVDAAVtPEERHLS
K751‑ub PEERHLSkMQQNGyE
K751 PEERHLSKMQQNGyE
Y757‑p SkMQQNGyENPTyKF
T761 QNGyENPTyKFFEQM
Y762‑p NGyENPTyKFFEQMQ
K763 GyENPTyKFFEQMQN
K763 GyENPTyKFFEQMQN
3823 : Phospho-APP (Thr668) Antibody
6986 : Phospho-APP (Thr668) (D90B8) Rabbit mAb
  APP iso2  
T107 RGRKQCKTHTHIVIP
T107 RGRKQCKTHTHIVIP
T109 RKQCKTHTHIVIPYR
Y115 HTHIVIPYRCLVGEF
S198 EESDSIDSADAEEDD
S206 ADAEEDDSDVWWGGA
- gap
- gap
T291 EEVVRVPTTAASTPD
T292 EVVRVPTTAASTPDA
T292 EVVRVPTTAASTPDA
T292 EVVRVPTTAASTPDA
S295 RVPTTAASTPDAVDK
S295 RVPTTAASTPDAVDK
T296 VPTTAASTPDAVDKY
Y303 TPDAVDKYLETPGDE
T306 AVDKYLETPGDENEH
T306 AVDKYLETPGDENEH
K320 HAHFQKAKERLEAKH
S366 HFQEKVESLEQEAAN
T525 LMPSLTETKTTVELL
T576 PAADRGLTTRPGSGL
T577 AADRGLTTRPGSGLT
S581 GLTTRPGSGLTNIKT
T584 TRPGSGLTNIKTEEI
K587 GSGLTNIKTEEISEV
T588 SGLTNIKTEEISEVK
S592 NIKTEEISEVKMDAE
K595 TEEISEVKMDAEFGH
S604 DAEFGHDSGFEVRHQ
K612 GFEVRHQKLVFFAED
S622 FFAEDVGSNKGAIIG
K624 AEDVGSNKGAIIGLM
K649 VITLVMLKKKQYTSI
K649 VITLVMLKKKQYTSI
K649 VITLVMLKKKQYTSI
K650 ITLVMLKKKQYTSIH
K650 ITLVMLKKKQYTSIH
K650 ITLVMLKKKQYTSIH
K651 TLVMLKKKQYTSIHH
K651 TLVMLKKKQYTSIHH
Y653 VMLKKKQYTSIHHGV
T654 MLKKKQYTSIHHGVV
S655 LKKKQYTSIHHGVVE
T668‑p VEVDAAVtPEERHLS
K676‑ub PEERHLSkMQQNGYE
K676 PEERHLSKMQQNGYE
Y682 SkMQQNGYENPTYKF
T686 QNGYENPTYKFFEQM
Y687 NGYENPTYKFFEQMQ
K688 GYENPTYKFFEQMQN
K688 GYENPTYKFFEQMQN
3823 : Phospho-APP (Thr668) Antibody
6986 : Phospho-APP (Thr668) (D90B8) Rabbit mAb
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