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Protein Page:
FOXO4 (human)

FOXO4 transcription factor AFX1 containing 1 fork-head domain. May play a role in the insulin signaling pathway. Involved in acute leukemias by a chromosomal translocation t(X;11)(q13;q23) that involves MLLT7 and MLL/HRX. The result is a rogue activator protein. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: beta-catenin binding; DNA binding; enzyme binding; identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: cell cycle arrest; insulin receptor signaling pathway; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; stem cell differentiation; transcription from RNA polymerase II promoter
Reference #:  P98177 (UniProtKB)
Alt. Names/Synonyms: AFX; AFX1; Fork head domain transcription factor AFX1; forkhead box O4; Forkhead box protein O4; FOXO4; MGC120490; MLLT7; translocated to, 7
Gene Symbols: FOXO4
Molecular weight: 53,684 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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