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Protein Page:
PSMD4 (human)

PSMD4 Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion. The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Directly interacts with NUB1. Interacts with SQSTM1. Interacts with UBQLN4. Belongs to the proteasome subunit S5A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; proteasome complex
Molecular Function: polyubiquitin binding; protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; proteasome assembly; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  P55036 (UniProtKB)
Alt. Names/Synonyms: 26S protease subunit S5a; 26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit S5A; AF; AF-1; angiocidin; Antisecretory factor 1; ASF; MCB1; multiubiquitin chain binding protein; Multiubiquitin chain-binding protein; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; proteasome 26S non-ATPase subunit 4; PSMD4; pUB-R5; Rpn10; RPN10 homolog; S5A; S5a/antisecretory factor protein
Gene Symbols: PSMD4
Molecular weight: 40,737 Da
Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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