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Protein Page:
ITGA2B (human)

Overview
ITGA2B Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: cell surface; integral to plasma membrane; plasma membrane; platelet alpha granule membrane
Molecular Function: identical protein binding; protein binding
Biological Process: cell adhesion; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; platelet degranulation
Disease: Bleeding Disorder, Platelet-type, 16; Glanzmann Thrombasthenia
Reference #:  P08514 (UniProtKB)
Alt. Names/Synonyms: CD41; CD41B; GP2B; GPalpha IIb; GPIIb; GTA; HPA3; integrin alpha 2b; Integrin alpha-IIb; Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITA2B; ITGA2B; ITGAB; platelet fibrinogen receptor, alpha subunit; Platelet membrane glycoprotein IIb; platelet-specific antigen BAK
Gene Symbols: ITGA2B
Molecular weight: 113,377 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITGA2B

Protein Structure Not Found.
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Download ChimeraX Script


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 L5 ___MARALCPLQALW
0 1 A10 RALCPLQALWLLEWV
0 1 S60‑p SLDFHKDsHGRVAIV
0 1 T73‑p IVVGAPRtLGPSQEE
0 1 Y197‑p DFSWDKRyCEAGFSS
0 1 S253 HVSSQSLSFDSSNPE
0 1 F254 VSSQSLSFDSSNPEY
0 1 S257 QSLSFDSSNPEYFDG
0 1 Y265 NPEYFDGYWGYSVAV
0 1 Y319‑p RGEQMASyFGHSVAV
0 1 Y344‑p LLVGAPLyMESRADR
0 1 Y360‑p LAEVGRVyLFLQPRG
0 1 Y384‑p LLTGTQLyGRFGSAI
  mouse

 
S5‑p ___MARAsCAWHsLW
S10‑p RAsCAWHsLWLLQWT
K60 SVDFHKDKHGSVSIV
A73 IVVGAPRALNASQEE
Y196 SFRGDKRYCEAGFSL
T252‑p HVSNQRFtyDNsNPV
Y253‑p VSNQRFtyDNsNPVF
S256‑p QRFtyDNsNPVFFDG
Y264‑p NPVFFDGyRGYSVAV
Y318 HGEQMASYFGHSVAV
Y343 LLVGAPLYMESRADR
Y359 LAEVGRVYLFLQPKG
Y383 LLTGTQLYGRFGSAI
  zebrafish

 
- gap
- gap
S52 SVDFYQSSSKSVSVV
A65 VVVGAPRANTNQSGV
Y190 RGYPDRRYCEAGFTT
T244 KHSMNGETKTPQRRD
K245 HSMNGETKTPQRRDY
Q248 NGETKTPQRRDYYDL
Y256 RRDYYDLYLGYSVAA
Y312 SGTQIASYFGHSVAV
F337 ILIGAPLFMEQLSTQ
Y353 FREVGQVYVYLQRND
Y377 ILAGTYAYGRFGSAI
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