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Protein Page:
RRM2 (human)

RRM2 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Belongs to the ribonucleoside diphosphate reductase small chain family. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component: cytosol; nucleoplasm
Molecular Function: protein binding; ribonucleoside-diphosphate reductase activity
Biological Process: deoxyribonucleotide biosynthetic process; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; nucleobase, nucleoside and nucleotide interconversion
Reference #:  P31350 (UniProtKB)
Alt. Names/Synonyms: R2; Ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase M2; ribonucleotide reductase M2 polypeptide; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; RIR2; RR2; RR2M; RRM2
Gene Symbols: RRM2
Molecular weight: 44,878 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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