Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, Rab
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding
Biological Process: blood coagulation; early endosome to late endosome transport; endocytosis; intracellular protein transport; nucleocytoplasmic transport; positive regulation of exocytosis; regulation of endocytosis; regulation of endosome size; regulation of filopodium formation; small GTPase mediated signal transduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.