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Protein Page:
Aiolos (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Aiolos a transcription factor of the ikaros C2H2-type zinc-finger protein family. Plays an important role in the regulation of lymphocyte differentiation. Deletions in Aiolos have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytoplasm; nucleus; plasma membrane
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity
Biological Process: mesoderm development; positive regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of B cell differentiation; regulation of B cell proliferation; regulation of lymphocyte differentiation; regulation of transcription from RNA polymerase II promoter
Reference #:  Q9UKT9 (UniProtKB)
Alt. Names/Synonyms: AIO; AIOLOS; IKAROS family zinc finger 3 (Aiolos); Ikaros family zinc finger protein 3; IKZF3; Zinc finger protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); ZNFN1A3
Gene Symbols: IKZF3
Molecular weight: 58,023 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Aiolos

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 N7 _MEDIQTNAELKSTQ
0 1 A20 TQEQSVPAESAAVLN
0 3 S22 EQSVPAESAAVLNDY
0 1 S42 HEMENVDSGEGPANE
0 2 S57‑p DEDIGDDsMKVKDEY
0 1 K73‑ub ERDENVLksEPMGNA
0 1 S74‑p RDENVLksEPMGNAE
0 1 S90‑p PEIPYSYsREYNEyE
0 4 Y96‑p YsREYNEyENIkLER
0 1 K100‑ub YNEyENIkLERHVVS
0 1 K100‑sm YNEyENIkLERHVVS
0 1 S115‑p FDSSRPTsGKMNCDV
0 1 S139 VLMVHKRSHtGERPF
0 3 T141‑p MVHKRSHtGERPFQC
0 4 T169‑p LRHIKLHtGEKPFKC
0 1 K200‑ub LRTHSVEkPYkCEFC
0 1 Y202 THSVEkPYkCEFCGR
0 8 K203‑ub HSVEkPYkCEFCGRS
0 1 S238 TDPGDTASAEARHIk
0 1 K245‑ac SAEARHIkAEMGSER
0 13 K245‑ub SAEARHIkAEMGSER
0 1 K245‑sm SAEARHIkAEMGSER
0 2 S261‑p LVLDRLAsNVAkRKS
0 1 K265‑ub RLAsNVAkRKSSMPQ
0 1 K273 RKSSMPQKFIGEKRH
0 1 K273‑ub RKSSMPQkFIGEKRH
0 1 K278 PQkFIGEKRHCFDVN
0 1 Y286‑p RHCFDVNyNSSyMYE
0 1 Y290‑p DVNyNSSyMYEKESE
0 2 T326‑p ALRPLVQtPPAPTSE
0 5 K361‑ub GAPQELEkkSIHLPE
0 3 K362‑ub APQELEkkSIHLPEk
0 1 K369 kSIHLPEKSVPSERG
0 2 K369‑ub kSIHLPEkSVPSERG
0 5 S378‑p VPSERGLsPNNSGHD
0 1 S386 PNNSGHDSTDTDSNH
0 2 S391 HDSTDTDSNHEERQN
0 1 K419‑ub RNGMPLLkEVPRSYE
0 8 K429‑ub PRSYELLkPPPICPR
0 3 K444‑ub DSVKVINkEGEVMDV
  Aiolos iso5  
N7 _MEDIQTNAELKSTQ
A20 TQEQSVPAESAAVLN
S22 EQSVPAESAAVLNDY
S42 HEMENVDSGEGPANE
S57 DEDIGDDSMKVKDEY
K73 ERDENVLKSEPMGNA
S74 RDENVLKSEPMGNAE
S90 PEIPYSYSREYNEYE
Y96 YSREYNEYENIKLER
K100 YNEYENIKLERHVVS
K100 YNEYENIKLERHVVS
S115 FDSSRPTSGKMNCDV
S139 VLMVHKRSHtASAEA
T141‑p MVHKRSHtASAEARH
- gap
- gap
- gap
- gap
S143 HKRSHtASAEARHIK
K150 SAEARHIKAEMGSER
K150 SAEARHIKAEMGSER
K150 SAEARHIKAEMGSER
S166 LVLDRLASNVAKRKS
K170 RLASNVAKRKSSMPQ
K178 RKSSMPQKFIGEKRH
K178 RKSSMPQKFIGEKRH
K183 PQKFIGEKRHCFDVN
Y191 RHCFDVNYNSSYMYE
Y195 DVNYNSSYMYEKESE
T231 ALRPLVQTPPAPTSE
K266 GAPQELEKKSIHLPE
K267 APQELEKKSIHLPEK
K274 KSIHLPEKSVPSERG
K274 KSIHLPEKSVPSERG
S283 VPSERGLSPNNSGHD
S291 PNNSGHDSTDTDSNH
S296 HDSTDTDSNHEERQN
K324 RNGMPLLKEVPRSYE
K334 PRSYELLKPPPICPR
K349 DSVKVINKEGEVMDV
  Aiolos iso15  
N7 _MEDIQTNAELKSTQ
A20 TQEQSVPAESAAVLN
S22 EQSVPAESAAVLNDY
S42 HEMENVDSGEGPANE
S57 DEDIGDDSMKVKDEY
K73 ERDENVLKSEPMGNA
S74 RDENVLKSEPMGNAE
S90 PEIPYSYSREYNEYE
Y96 YSREYNEYENIKLER
K100 YNEYENIKLERHVVS
K100 YNEYENIKLERHVVS
S115 FDSSRPTSGKMNCDV
S139‑p VLMVHKRsHtVEKPy
T141‑p MVHKRsHtVEKPyKC
- gap
K144 KRsHtVEKPyKCEFC
Y146‑p sHtVEKPyKCEFCGR
K147 HtVEKPyKCEFCGRS
T182 TDPGDTGTGWGWVEL
- gap
- gap
- gap
- gap
K209 PWCRLHAKRKSSMPQ
K217 RKSSMPQKFIGEKRH
K217 RKSSMPQKFIGEKRH
K222 PQKFIGEKRHCFDVN
Y230 RHCFDVNYNSSYMYE
Y234 DVNYNSSYMYEKESE
T270 ALRPLVQTPPAPTSE
K305 GAPQELEKKSIHLPE
K306 APQELEKKSIHLPEK
K313 KSIHLPEKSVPSERG
K313 KSIHLPEKSVPSERG
S322 VPSERGLSPNNSGHD
S330 PNNSGHDSTDTDSNH
S335 HDSTDTDSNHEERQN
K363 RNGMPLLKEVPRSYE
K373 PRSYELLKPPPICPR
K388 DSVKVINKEGEVMDV
  mouse

 
T7‑p _MEDIQPtVELKSTE
T20‑p TEEQPLPtEsPDALN
S22‑p EQPLPtEsPDALNDY
S42‑p HEIENVDsREAPANE
S57 DEDAGEDSMKVKDEY
K73 DRDENIMKPEPMGDA
P74 RDENIMKPEPMGDAE
A90 SEMPYSYAREYSDYE
Y96 YAREYSDYESIKLER
K100 YSDYESIKLERHVPY
K100 YSDYESIKLERHVPY
G114 YDNSRPTGGKMNCDV
S138 VLMVHKRSHTGERPF
T140 MVHKRSHTGERPFQC
T168‑p LRHIKLHtGEKPFKC
K199 LRTHSVEKPYKCEFC
Y201 THSVEKPYKCEFCGR
K202 HSVEKPYKCEFCGRS
S237 PDLGDAASVEARHIk
K244 SVEARHIKAEMGSER
K244‑ub SVEARHIkAEMGSER
K244 SVEARHIKAEMGSER
S260‑p LVLDRLAsNVAKRKS
K264 RLAsNVAKRKSSMPQ
K272 RKSSMPQKFIGEKRH
K272 RKSSMPQKFIGEKRH
K277 PQKFIGEKRHCFDAN
Y285 RHCFDANYNPGYMYE
Y289 DANYNPGYMYEKENE
T325‑p ALRPLVQtPPAPTSE
K360 GAPQEMEKKRILLPE
K361 APQEMEKKRILLPEK
K368 KRILLPEKILPSERG
K368 KRILLPEKILPSERG
S377‑p LPSERGLsPNNSAQD
S385‑p PNNSAQDsTDTDsNH
S390‑p QDsTDTDsNHEDRQH
K417 RNGMPLLKEVPRSFE
K427 PRSFELLKPPPICLR
K442 DSIKVINKEGEVMDV
  rat

 
S7 _MEDIQPSAELKSTE
T20 TEEQPLPTEsPEALN
S22‑p EQPLPTEsPEALNDY
G42 HEIENVDGTEAPANE
L57 DEDAGEDLMMKVKDE
K74 ERDENILKPEPMVDA
P75 RDENILKPEPMVDAE
A91 SEPPYSYAREYSDYE
Y97 YAREYSDYENIKLER
K101 YSDYENIKLERHGPY
K101 YSDYENIKLERHGPY
S115 YDSSRPTSGKMNCDV
S139 VLMVHKRSHTGERPF
T141 MVHKRSHTGERPFQC
T169 LRHIKLHTGEKPFKC
K200 LRTHSVEKPYKCEFC
Y202 THSVEKPYKCEFCGR
K203 HSVEKPYKCEFCGRS
S238‑p PDLGDAAsVEARHIK
K245 sVEARHIKAEMGSER
K245 sVEARHIKAEMGSER
K245 sVEARHIKAEMGSER
S261 LVLDRLASNVAKRKS
K265 RLASNVAKRKSSMPQ
K273‑ac RKSSMPQkFIGEkRH
K273 RKSSMPQKFIGEkRH
K278‑ac PQkFIGEkRHCFDAN
Y286 RHCFDANYNPGYMYE
Y290 DANYNPGYMYEKENE
T326 ALRPLVQTPPAPTSE
K361 GAPQELEKKRILLPE
K362 APQELEKKRILLPEk
K369‑ac KRILLPEkILPSERG
K369 KRILLPEKILPSERG
S378‑p LPSERGLsPNNSAQD
S386 PNNSAQDSTDTDsNH
S391‑p QDSTDTDsNHEDRQN
K419 RNGMPLLKEVPRSFE
K429 PRSFELLKPPPICLR
K444 DSIKVINKEGEVMDV
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