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Protein Page:
CA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

CA2 Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala- His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO(3)). Esterase activity weakly reduced by cyanamide. N- hydroxyurea interfers with zinc binding and inhibit activity. Belongs to the alpha-carbonic anhydrase family. Note: This description may include information from UniProtKB.
Protein type: Lyase; Energy Metabolism - nitrogen; EC
Chromosomal Location of Human Ortholog: 8q22
Cellular Component: apical part of cell; axon; basolateral plasma membrane; cytoplasm; cytosol; extracellular space; microvillus; myelin sheath; plasma membrane
Molecular Function: arylesterase activity; carbonate dehydratase activity; protein binding; zinc ion binding
Biological Process: bicarbonate transport; carbon dioxide transport; kidney development; morphogenesis of an epithelium; odontogenesis of dentine-containing teeth; one-carbon compound metabolic process; positive regulation of bone resorption; positive regulation of cellular pH reduction; positive regulation of osteoclast differentiation; positive regulation of synaptic transmission, GABAergic; regulation of intracellular pH; response to estrogen stimulus; response to pH; response to zinc ion; secretion
Disease: Osteopetrosis, Autosomal Recessive 3
Reference #:  P00918 (UniProtKB)
Alt. Names/Synonyms: CA-II; CA2; CAC; CAH2; CAII; Car2; Carbonate dehydratase II; Carbonic anhydrase 2; carbonic anhydrase B; Carbonic anhydrase C; Carbonic anhydrase II
Gene Symbols: CA2
Molecular weight: 29,246 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.