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Protein Page:
CA2 (human)

Overview
CA2 Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala- His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO(3)). Esterase activity weakly reduced by cyanamide. N- hydroxyurea interfers with zinc binding and inhibit activity. Belongs to the alpha-carbonic anhydrase family. Note: This description may include information from UniProtKB.
Protein type: EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase
Chromosomal Location of Human Ortholog: 8q22
Cellular Component: apical part of cell; cytoplasm; cytosol; plasma membrane
Molecular Function: arylesterase activity; carbonate dehydratase activity; protein binding; zinc ion binding
Biological Process: bicarbonate transport; regulation of intracellular pH
Disease: Osteopetrosis, Autosomal Recessive 3
Reference #:  P00918 (UniProtKB)
Alt. Names/Synonyms: CA-II; CA2; CAC; CAH2; CAII; Car2; Carbonate dehydratase II; Carbonic anhydrase 2; carbonic anhydrase B; Carbonic anhydrase C; Carbonic anhydrase II
Gene Symbols: CA2
Molecular weight: 29,246 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CA2

Protein Structure Not Found.