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Protein Page:
UBE2B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UBE2B a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system; Ligase
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: chromatin; cytoplasm; nuclear chromatin; nucleoplasm; nucleus; plasma membrane; replication fork; XY body
Molecular Function: ATP binding; protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: chiasma formation; DNA damage response, detection of DNA damage; DNA repair; histone H2A ubiquitination; in utero embryonic development; maintenance of chromatin silencing; negative regulation of apoptosis; negative regulation of histone phosphorylation; postreplication repair; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein monoubiquitination; protein polyubiquitination; protein stabilization; protein ubiquitination; response to DNA damage stimulus; response to drug; response to UV; sperm axoneme assembly; spermatogenesis; telomere clustering; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway through beta-catenin
Reference #:  P63146 (UniProtKB)
Alt. Names/Synonyms: E2 protein; E2-17kDa; hHR6B; HR6B; RAD6 homolog B; RAD6B; UBC2; UBE2B; Ubiquitin carrier protein B; Ubiquitin-conjugating enzyme E2 B; Ubiquitin-conjugating enzyme E2-17 kDa; ubiquitin-conjugating enzyme E2B (RAD6 homolog); Ubiquitin-protein ligase B
Gene Symbols: UBE2B
Molecular weight: 17,312 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Select Structure to View Below

UBE2B

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K66‑ac FSEEYPNkPPtVRFL
0 1 K66‑ub FSEEYPNkPPtVRFL
0 1 T69‑p EYPNkPPtVRFLSKM
0 1 S120‑p LDEPNPNsPANSQAA
  mouse

 
K66 FSEEYPNKPPTVRFL
K66 FSEEYPNKPPTVRFL
T69 EYPNKPPTVRFLSKM
S120 LDEPNPNSPANSQAA
  rat

 
K66‑ac FSEEYPNkPPTVRFL
K66 FSEEYPNKPPTVRFL
T69 EYPNkPPTVRFLSKM
S120 LDEPNPNSPANSQAA
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