a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Ubiquitin ligase; Ubiquitin conjugating system; Ligase
Molecular Function: ATP binding; protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: chiasma formation; DNA damage response, detection of DNA damage; DNA repair; histone H2A ubiquitination; in utero embryonic development; maintenance of chromatin silencing; negative regulation of apoptosis; negative regulation of histone phosphorylation; postreplication repair; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein monoubiquitination; protein polyubiquitination; protein stabilization; protein ubiquitination; response to DNA damage stimulus; response to drug; response to UV; sperm axoneme assembly; spermatogenesis; telomere clustering; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway through beta-catenin
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.