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Protein Page:
UBE2A (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UBE2A a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system; Ligase
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: chromatin; cytoplasm; cytosol; nuclear chromatin; XY body
Molecular Function: ATP binding; protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: antigen processing and presentation of peptide antigen via MHC class I; DNA repair; histone H2A ubiquitination; in utero embryonic development; maternal process involved in pregnancy; positive regulation of cell proliferation; postreplication repair; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein polyubiquitination; response to UV; ubiquitin-dependent protein catabolic process
Disease: Mental Retardation, X-linked, Syndromic, Nascimento Type
Reference #:  P49459 (UniProtKB)
Alt. Names/Synonyms: hHR6A; HR6A; RAD6 homolog A; RAD6A; UBC2; UBE2A; Ubiquitin carrier protein A; Ubiquitin-conjugating enzyme E2 A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); Ubiquitin-protein ligase A
Gene Symbols: UBE2A
Molecular weight: 17,315 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UBE2A

Protein Structure Not Found.


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Modification Sites and Domains  
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Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K66‑ac FTEEYPNkPPTVRFV
0 15 K66‑ub FTEEYPNkPPTVRFV
0 2 K75‑ub PTVRFVSkMFHPNVY
1 1 S120‑p LDEPNPNsPANSQAA
0 2 S142‑p REYEKRVsAIVEQsW
0 1 S148‑p VsAIVEQsWRDC___
  mouse

 
K66 FTEEYPNKPPTVRFV
K66‑ub FTEEYPNkPPTVRFV
K75 PTVRFVSKMFHPNVY
S120 LDEPNPNSPANSQAA
S142 REYEKRVSAIVEQSW
S148 VSAIVEQSWRDC___
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