a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 220.127.116.11; Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; STE group; STE7 family
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.