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Protein Page:
MKK6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MKK6 a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, dual-specificity (non-receptor); EC 2.7.12.2; Protein kinase, STE; Kinase, protein; STE group; STE7 family
Chromosomal Location of Human Ortholog: 17q24.3
Cellular Component: cytoplasm; cytoskeleton; cytosol; nucleoplasm
Molecular Function: ATP binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein-tyrosine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; apoptosis; cardiac muscle contraction; cell cycle arrest; DNA damage induced protein phosphorylation; MAPKKK cascade; ovulation cycle process; peptidyl-tyrosine phosphorylation; positive regulation of apoptosis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of prostaglandin secretion; regulation of transcription, DNA-dependent; response to drug; signal transduction; transcription, DNA-dependent
Reference #:  P52564 (UniProtKB)
Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAP2K6; MAPK/ERK kinase 6; MAPKK 6; MAPKK6; MEK 6; MEK6; mitogen-activated protein kinase kinase 6; MKK6; MP2K6; PRKMK6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPKK3
Gene Symbols: MAP2K6
Molecular weight: 37,492 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Regulation of P38 MAPKs  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MKK6

Protein Structure Not Found.
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Sites Implicated In
transcription, induced: S207‑p, T211‑p
enzymatic activity, induced: S207‑p, T211‑p
enzymatic activity, inhibited: S207‑ac, T211‑ac
molecular association, regulation: Y219‑p
phosphorylation: S207‑ac, T211‑ac

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K5‑ac ___MSQSkGKkRNPG
0 1 K8‑ac MSQSkGKkRNPGLKI
0 1 S27‑p FEQPQTSstPPRDLD
0 14 T28‑p EQPQTSstPPRDLDS
0 2 Y64‑p MELGRGAyGVVEKMR
0 2 K82‑ac SGQIMAVkRIRATVN
0 1 S201‑p KMCDFGIsGYLVDsV
1 0 S207‑ac IsGYLVDsVAKtIDA
12 71 S207‑p IsGYLVDsVAKtIDA
1 0 T211‑ac LVDsVAKtIDAGCKP
3 3 T211‑p LVDsVAKtIDAGCKP
1 0 Y219‑p IDAGCKPyMAPERIN
0 1 K232 INPELNQKGYSVKSD
9231 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) Antibody
12280 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) (D8E9) Rabbit mAb
  MKK6 iso2  
- gap
- gap
- gap
- gap
Y8 MELGRGAYGVVEKMR
K26 SGQIMAVKRIRATVN
S145 KMCDFGISGYLVDsV
S151 ISGYLVDSVAKtIDA
S151‑p ISGYLVDsVAKtIDA
T155 LVDsVAKTIDAGCKP
T155‑p LVDsVAKtIDAGCKP
Y163 IDAGCKPYMAPERIN
K176 INPELNQKGYSVKSD
  mouse

 
K5 ___MSQSKGKKRNPG
K8 MSQSKGKKRNPGLKI
S27 FEQPQTSStPPRDLD
T28‑p EQPQTSStPPRDLDS
Y64 VELGRGAYGVVEKMR
K82 SGQIMAVKRIRATVN
S201 KMCDFGISGYLVDsV
S207 ISGYLVDSVAKtIDA
S207‑p ISGYLVDsVAKtIDA
T211 LVDsVAKTIDAGCKP
T211‑p LVDsVAKtIDAGCKP
Y219 IDAGCKPYMAPERIN
K232‑ub INPELNQkGYSVKSD
9231 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) Antibody
9236 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) (22A8) Rabbit mAb
12280 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) (D8E9) Rabbit mAb
  rat

 
K5 ___MSQSKGKKRNPG
K8 MSQSKGKKRNPGLKI
S27 FEQPQTSSTPPRDLD
T28 EQPQTSSTPPRDLDS
Y64 VELGRGAYGVVEKMR
K82 SGQIMAVKRIRATVN
S201 KMCDFGISGYLVDsV
S207 ISGYLVDSVAKTIDA
S207‑p ISGYLVDsVAKTIDA
T211 LVDsVAKTIDAGCKP
T211 LVDsVAKTIDAGCKP
Y219 IDAGCKPYMAPERIN
K232 INPELNQKGYSVKSD
9231 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) Antibody
9236 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) (22A8) Rabbit mAb
12280 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) (D8E9) Rabbit mAb
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