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Protein Page:
MKK6 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MKK6 a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; Kinase, protein; STE group; STE7 family
Chromosomal Location of Human Ortholog: 17q24.3
Cellular Component: cytoplasm; cytoskeleton; cytosol; nucleoplasm
Molecular Function: ATP binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity
Biological Process: activation of MAPK activity; apoptosis; cardiac muscle contraction; cell cycle arrest; DNA damage induced protein phosphorylation; innate immune response; muscle cell differentiation; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; ovulation cycle process; peptidyl-tyrosine phosphorylation; positive regulation of apoptosis; positive regulation of muscle cell differentiation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of prostaglandin secretion; regulation of apoptosis; regulation of mitotic cell cycle; regulation of transcription, DNA-dependent; response to drug; signal transduction; stress-activated MAPK cascade; stress-activated protein kinase signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription, DNA-dependent
Reference #:  P52564 (UniProtKB)
Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAP2K6; MAPK/ERK kinase 6; MAPKK 6; MAPKK6; MEK 6; MEK6; mitogen-activated protein kinase kinase 6; MKK6; MP2K6; PRKMK6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPKK3
Gene Symbols: MAP2K6
Molecular weight: 37,492 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Regulation of P38 MAPKs  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MKK6

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S207‑p, T211‑p
enzymatic activity, induced: S207‑p, T211‑p
enzymatic activity, inhibited: S207‑ac, T211‑ac
molecular association, regulation: Y219‑p
phosphorylation: S207‑ac, T211‑ac

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K5‑ac ___MSQSkGKkRNPG
0 1 K8‑ac MSQSkGKkRNPGLKI
0 1 S27‑p FEQPQTSstPPRDLD
0 13 T28‑p EQPQTSstPPRDLDS
0 2 Y64‑p MELGRGAyGVVEKMR
0 2 K82‑ac SGQIMAVkRIRATVN
0 1 S201‑p KMCDFGIsGYLVDsV
1 0 S207‑ac IsGYLVDsVAKtIDA
12 70 S207‑p IsGYLVDsVAKtIDA
1 0 T211‑ac LVDsVAKtIDAGCKP
3 3 T211‑p LVDsVAKtIDAGCKP
1 0 Y219‑p IDAGCKPyMAPERIN
0 1 K232 INPELNQKGYSVKSD
9231 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) Antibody
12280 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) (D8E9) Rabbit mAb
  MKK6 iso2  
- gap
- gap
- gap
- gap
Y8 MELGRGAYGVVEKMR
K26 SGQIMAVKRIRATVN
S145 KMCDFGISGYLVDsV
S151 ISGYLVDSVAKtIDA
S151‑p ISGYLVDsVAKtIDA
T155 LVDsVAKTIDAGCKP
T155‑p LVDsVAKtIDAGCKP
Y163 IDAGCKPYMAPERIN
K176 INPELNQKGYSVKSD
  mouse

 
K5 ___MSQSKGKKRNPG
K8 MSQSKGKKRNPGLKI
S27 FEQPQTSStPPRDLD
T28‑p EQPQTSStPPRDLDS
Y64 VELGRGAYGVVEKMR
K82 SGQIMAVKRIRATVN
S201 KMCDFGISGYLVDsV
S207 ISGYLVDSVAKtIDA
S207‑p ISGYLVDsVAKtIDA
T211 LVDsVAKTIDAGCKP
T211‑p LVDsVAKtIDAGCKP
Y219 IDAGCKPYMAPERIN
K232‑ub INPELNQkGYSVKSD
9231 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) Antibody
9236 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) (22A8) Rabbit mAb
12280 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) (D8E9) Rabbit mAb
  rat

 
K5 ___MSQSKGKKRNPG
K8 MSQSKGKKRNPGLKI
S27 FEQPQTSSTPPRDLD
T28 EQPQTSSTPPRDLDS
Y64 VELGRGAYGVVEKMR
K82 SGQIMAVKRIRATVN
S201 KMCDFGISGYLVDsV
S207 ISGYLVDSVAKTIDA
S207‑p ISGYLVDsVAKTIDA
T211 LVDsVAKTIDAGCKP
T211 LVDsVAKTIDAGCKP
Y219 IDAGCKPYMAPERIN
K232 INPELNQKGYSVKSD
9231 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) Antibody
9236 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) (22A8) Rabbit mAb
12280 : Phospho-MKK3 (Ser189)/MKK6 (Ser207) (D8E9) Rabbit mAb
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