a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Molecular Function: MAP kinase kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; activation of protein kinase activity; cell cycle arrest; DNA damage induced protein phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; signal transduction; stress-activated protein kinase signaling pathway