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Protein Page:
CTBP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CTBP2 Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 10q26.13
Cellular Component: nucleus; transcriptional repressor complex
Molecular Function: protein binding; protein homodimerization activity; transcription corepressor activity
Biological Process: negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; viral genome replication; white fat cell differentiation
Reference #:  P56545 (UniProtKB)
Alt. Names/Synonyms: C-terminal binding protein 2; C-terminal-binding protein 2; CTBP2; ribeye
Gene Symbols: CTBP2
Molecular weight: 48,945 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTBP2

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
1 0 K6‑ac __MALVDkHkVkRQR
1 0 K8‑ac MALVDkHkVkRQRLD
1 0 K10‑ac LVDkHkVkRQRLDRI
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 2 - gap
0 1 - gap
0 1 - gap
0 2 - gap
0 1 - gap
0 2 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 R22‑m2 DRICEGIrPQIMNGP
0 6 Y108‑p IVRIGSGyDNVDIKA
1 0 S164‑p REGTRVQsVEQIREV
0 5 K279‑ub RGGLVDEkALAQALk
0 16 K286‑ub kALAQALkEGRIRGA
0 1 S365‑p NKEFFVTsAPWsVID
0 1 S369‑p FVTsAPWsVIDQQAI
0 1 T414‑p IPGGIPVtHNLPTVA
0 2 S424 LPTVAHPSQAPsPNQ
1 5 S428‑p AHPSQAPsPNQPTKH
0 1 T433 APsPNQPTKHGDNRE
  CTBP2 iso2  
S5 ___MPVPSRHINIGR
- gap
- gap
- gap
S94‑p PDFTFYDsRQAVMsG
S100‑p DsRQAVMsGRSPLLP
T179‑p MIPQGRQtQsRAAsP
S181‑p PQGRQtQsRAAsPGR
S185‑p QtQsRAAsPGRYGRE
T196‑p YGREQPDtRyGAEVP
Y198‑p REQPDtRyGAEVPAY
Y257‑p PGALNRGyGPARESI
S266‑p PARESIPsKMAyETY
Y270‑p SIPsKMAyETYEADL
S504 VAASPLPSPHGSPQV
S508 PLPSPHGSPQVLRKP
A556 IIVSTMLAPEPSIRP
S560 TMLAPEPSIRPQIMN
R562 LAPEPSIRPQIMNGP
Y648 IVRIGSGYDNVDIKA
S704 REGTRVQSVEQIREV
K819 RGGLVDEKALAQALK
K826 KALAQALKEGRIRGA
S905 NKEFFVTSAPWSVID
S909 FVTSAPWSVIDQQAI
T954 IPGGIPVTHNLPTVA
S964 LPTVAHPSQAPSPNQ
S968 AHPSQAPSPNQPTKH
T973 APSPNQPTKHGDNRE
  mouse

► Hide Isoforms
 
- gap
K6 __MALVDKHKVKRQR
K8 MALVDKHKVKRQRLD
K10 LVDKHKVKRQRLDRI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
R22‑m2 DRICEGIrPQIMNGP
Y108 IVRIGSGYDNVDIKA
S164 REGTRVQSVEQIREV
K279‑ub RGGLVDEkALAQALk
K286‑ub kALAQALkEGRIRGA
S365‑p NKEFFVTsAPWSVID
S369 FVTsAPWSVIDQQAI
T414 IPGGIPVTHNLPTVA
S424‑p LPTVAHPsQAPsPNQ
S428‑p AHPsQAPsPNQPtKH
T433‑p APsPNQPtKHGDNRE
  CTBP2 iso2  
S5 ___MPVPSRHINIGR
- gap
- gap
- gap
S86 PDFTFYDSRQAVMSG
S92 DSRQAVMSGRGSVLP
T171 TVPHGQRTHGRAPSP
G173 PHGQRTHGRAPSPGR
S177 RTHGRAPSPGRYGRE
T188 YGREQPDTRLGIEVP
L190 REQPDTRLGIEVPTY
Y251 PGSLNRGYGPTRESI
S260 PTRESIHSKLAYENY
Y264 SIHSKLAYENYEADL
S506 MTASPLPSPHGSPQL
S510 PLPSPHGSPQLLRKP
T559‑p IIVSTMLtPEPsIRP
S563‑p TMLtPEPsIRPQIMN
R565 LtPEPsIRPQIMNGP
Y651 IVRIGSGYDNVDIKA
S707 REGTRVQSVEQIREV
K822 RGGLVDEKALAQALK
K829 KALAQALKEGRIRGA
S908 NKEFFVTSAPWSVID
S912 FVTSAPWSVIDQQAI
T957 IPGGIPVTHNLPTVA
S967 LPTVAHPSQAPSPNQ
S971 AHPSQAPSPNQPTKH
T976 APSPNQPTKHGDNRE
  rat

► Hide Isoforms
 
- gap
K6 __MALVDKHKVKRQR
K8 MALVDKHKVKRQRLD
K10 LVDKHKVKRQRLDRI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
R22 DRICEGIRPQIMNGP
Y108 IVRIGSGYDNVDIKA
S164 REGTRVQSVEQIREV
K279 RGGLVDEKALAQALK
K286 KALAQALKEGRIRGA
S365 NKEFFVTSTPWSVID
S369 FVTSTPWSVIDQQAI
T414 IPGGIPVTHNLPTVA
S424 LPTVAHPSQAPSPNQ
S428 AHPSQAPSPNQPTKH
T433 APSPNQPTKHGDNRE
  CTBP2 iso2  
S5‑p ___MPVPsRHINIGR
- gap
- gap
- gap
S86 PDFTFYDSRQAVMSG
S92 DSRQAVMSGRGSVLP
T171 TVLHGQRTHCRAPSP
C173 LHGQRTHCRAPSPGR
S177 RTHCRAPSPGRYGRE
S188 YGREQPDSRLGIEVP
L190 REQPDSRLGIEVPTY
Y251 PGSLNRGYGPTRESI
S260 PTRESIHSKLAYENY
Y264 SIHSKLAYENYEADL
S506‑p VTASPLPsPHAsPQL
S510‑p PLPsPHAsPQLLRKP
T559 IIVSTMLTPEPSIRP
S563 TMLTPEPSIRPQIMN
R565 LTPEPSIRPQIMNGP
Y651 IVRIGSGYDNVDIKA
S707 REGTRVQSVEQIREV
K822 RGGLVDEKALAQALK
K829 KALAQALKEGRIRGA
S908 NKEFFVTSTPWSVID
S912 FVTSTPWSVIDQQAI
T957 IPGGIPVTHNLPTVA
S967 LPTVAHPSQAPSPNQ
S971 AHPSQAPSPNQPTKH
T976 APSPNQPTKHGDNRE
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