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Protein Page:
NOT2 (human)

Overview
NOT2 The CCR4-NOT complex functions as general transcription regulation complex. Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Belongs to the CNOT2/3/5 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: CCR4-NOT complex; cytoplasm; cytosol; membrane
Molecular Function: poly(A)-specific ribonuclease activity; protein binding
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA catabolic process, deadenylation-dependent decay; negative regulation of estrogen receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of translation; poly(A) tail shortening
Reference #:  Q9NZN8 (UniProtKB)
Alt. Names/Synonyms: CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex, subunit 2; CDC36; CNOT2; FLJ26456; HSPC131; NOT2; NOT2 (negative regulator of transcription 2, yeast) homolog; NOT2H
Gene Symbols: CNOT2
Molecular weight: 59,738 Da
Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NOT2

Protein Structure Not Found.
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